Results 31 to 40 of about 1,201 (149)
Role of Nrf2 and Its Activators in Respiratory Diseases
Oxidative Medicine and Cellular Longevity, Volume 2019, Issue 1, 2019., 2019 Transcription factor nuclear factor erythroid 2‐related factor 2 (Nrf2) is a major regulator of antioxidant response element‐ (ARE‐) driven cytoprotective protein expression. The activation of Nrf2 signaling plays an essential role in preventing cells and tissues from injury induced by oxidative stress.
Qinmei Liu +3 more
wiley +1 more source
Oxidative Medicine and Cellular Longevity, Volume 2019, Issue 1, 2019., 2019 Background. Aurothioglucose‐ (ATG‐) mediated inhibition of thioredoxin reductase‐1 (TXNRD1) improves alveolarization in experimental murine bronchopulmonary dysplasia (BPD). Glutathione (GSH) mediates susceptibility to neonatal and adult oxidative lung injury. We have previously shown that ATG attenuates hyperoxic lung injury and enhances glutathione‐ (
Stephanie B. Wall +7 more
wiley +1 more source
Thioredoxin reductase 1 suppresses adipocyte differentiation and insulin responsiveness [PDF]
, 2016 Recently thioredoxin reductase 1 (TrxR1), encoded by Txnrd1, was suggested to modulate glucose and lipid metabolism in mice. Here we discovered that TrxR1 suppresses insulin responsiveness, anabolic metabolism and adipocyte differentiation.
Arnér, Elias S. J. +5 more
core +2 more sources
Oxidative Medicine and Cellular Longevity, Volume 2016, Issue 1, 2016., 2016 Over the last decade, a diverse spectrum of vanadium compounds has arisen as anti‐inflammatory therapeutic metallodrugs targeting various diseases. Recent studies have demonstrated that select well‐defined vanadium species are involved in many immune‐driven molecular mechanisms that regulate and influence immune responses. In addition, advances in cell
Olga Tsave +8 more
wiley +1 more source
Two patients with acute thrombocytopenia following gold administration and five-year follow-up [PDF]
, 2003 Thrombocytopenia is a well-known side effect following intramuscular gold therapy in patients with rheumatoid arthritis. Thrombocytopenia may occur at any time and it can be irreversible and sometimes fatal despite cytotoxic or ...
Levin, M.-D. (Mark-David) +3 more
core +1 more source
A conceptually new treatment approach for relapsed glioblastoma: Coordinated undermining of survival paths with nine repurposed drugs (CUSP9) by the International Initiative for Accelerated Improvement of Glioblastoma Care [PDF]
, 2017 Kast, Richard E. et al.To improve prognosis in recurrent glioblastoma we developed a treatment protocol based on a combination of drugs not traditionally thought of as cytotoxic chemotherapy agents but that have a robust history of being well-tolerated ...
Halatsch, Marc-Eric +2 more
core +5 more sources
Journal of Oncology, Volume 2009, Issue 1, 2009., 2009 The hypothesis that the Akt inhibitor, perifosine (PER), combined with inhibitors of glutathione (GSH) and thioredoxin (Trx) metabolism will induce cytotoxicity via metabolic oxidative stress in human head and neck cancer (HNSCC) cells was tested. PER induced increases in glutathione disulfide (%GSSG) in FaDu, Cal‐27, and SCC‐25 HNSCCs as well as ...
Andrean L. Simons +6 more
wiley +1 more source
Study on Bioactive Components of Anoectochilus formosanus Hayata [PDF]
, 2011 本総説において以下の知見を得たのでこれらについて述べる｡1)ﾏｳｽを用いた金線連の薬理活性､特に肝障害改善作用について検討した｡2)ﾎﾞﾗﾝﾃｲｱによる脂質関連障害の改善傾向を認めた｡3)金線連の粗ｴｷｽから脂質代謝改善作用を指標として kinsenoside を単離し､本化合物が活性本体であることを明らかにした｡ﾗﾝ科に属する金線連(Anoectochilus formosanus Hayata)は台湾から沖縄にかけて自生しており､高血圧､肺障害､肝障害､小児の発育障害等に用いられてきた ...
DU Xiao-Ming +3 more
core +1 more source
Cycloaurated GoId (III) complexes- Possible alternatives to cisplatin? [PDF]
, 2009 The serendipitous discovery of the anti-tumour activity of cisplatin [cis-PtCI₂(NH₃)₂] in 1969 has led to increased interest in the development of new metal-based anti-cancer drugs.
Henderson, William, Kilpin, Kelly Joan
core +1 more source
Applied Organometallic Chemistry, Volume 38, Issue 10, October 2024.Heterometallic ReI/AuI complexes containing imidazo[4,5‐f]‐1,10‐phenanthroline (N^N^C) as polytopic ligand were synthesised and their antiproliferative and emissive potential analysed. The gold complex bearing a thiolate sugar derivative is the most active complex.
Andrés Luengo +3 more
wiley +1 more source