Characterisation and In Vitro Cytotoxicity of Triorganophosphinegold(I) 2‐Mercaptobenzoate Complexes
Metal-Based Drugs, Volume 6, Issue 1, Page 31-40, 1999., 1999 The preparation and full NMR ( 1H, 13C and 31P) characterisation of three R3PAu (2mba) complexes, Where R = Et, Ph and Cy, and 2mba is the anion derived from 2‐mercaptobenzoic acid is reported. An interesting solvent dependence in the 1H spectra is rationalised in terms of competing intra‐ and inter‐molecular hydrogen bonding. An X‐ray analysis of the [
Dick de Vos +4 more
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Synthesis and Coordination Behavior of a Bipyridine Platinum(II) Complex with Thioglucose [PDF]
, 2013 This document is the Accepted Manuscript version of a Published Work that appeared in final form in Inorganic Chemistry, © American Chemical Society after peer review and technical editing by the publisher.
Konno, Takumi +3 more
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Metal-Based Drugs, Volume 6, Issue 6, Page 361-368, 1999., 1999 The antitumour activities of four triorganophosphinegold(I) thiolates, R3PAu(S′R) [R = Ph, Cy, Et; SR′H = 6‐mercaptopurine and R Et; SR′H = 6‐thioguanine] against the National Cancer Institute (NCI) panel of 60 cell lines are reported The [Cy3PAu(6‐MP)] complex proved to be the more cytotoxic of the four complexes tested.
David Crump +2 more
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Asbestos modulates thioredoxin-thioredoxin interacting protein interaction to regulate inflammasome activation [PDF]
, 2014 BACKGROUND: Asbestos exposure is related to various diseases including asbestosis and malignant mesothelioma (MM). Among the pathogenic mechanisms proposed by which asbestos can cause diseases involving epithelial and mesothelial cells, the most widely ...
Arti Shukla +6 more
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The elements of life and medicines [PDF]
, 2015 Which elements are essential for human life? Here we make an element-by-element journey through the periodic table and attempt to assess whether elements are essential or not, and if they are, whether there is a relevant code for them in the human genome.
Chellan , Prinessa, Sadler, P. J.
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Protective Effects Of Thioredoxin Reductase Inhibition In The Murine Lung: The Regulation And Contribution Of Heme Oxygenase-1 [PDF]
, 2020 Endogenous antioxidant responses defend the lung against oxygen toxicity. In premature neonates, oxygen toxicity and impaired antioxidant defenses contribute to the development of bronchopulmonary dysplasia (BPD), the leading cause of long-term morbidity
Dunigan, Katelyn Louise
core
Thioredoxin reductase as a target enzyme for electrophilic anticancer drugs [PDF]
, 2011 Induced production of reactive oxygen species (ROS) is a common attribute of most cancer cells. One strategy for cancer cells to maneuver the increased and potentially toxic levels of ROS is to induce the expression of cellular antioxidants and ...
Eriksson, Sofi
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Thioredoxin Glutathione Reductase from Schistosoma mansoni: An Essential Parasite Enzyme and a Key Drug Target [PDF]
, 2007 Using both genetic and biochemical approaches, David Williams and colleagues show that the parasite thioredoxin glutathione reductase meets all the major criteria to be a key target for antischistosomal ...
Ahmed A Sayed +7 more
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A non-imaging high throughput approach to chemical library screening at the unmodified adenosine-A3 receptor in living cells [PDF]
, 2017 Recent advances in fluorescent ligand technology have enabled the study of G protein-coupled receptors in their native environment without the need for genetic modification such as addition of N-terminal fluorescent or bioluminescent tags.
Antonioli +59 more
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Negative Staining and Image Classification – Powerful Tools in Modern Electron Microscopy [PDF]
, 2004 Vitrification is the state-of-the-art specimen preparation technique for molecular electron microscopy (EM) and therefore negative staining may appear to be an outdated approach.
A Bremer +37 more
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