Results 31 to 40 of about 67,988 (149)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

The Consequence of the Siege of Temeşvar: Analysis and Evaluation of the Submission Letter of the Castellan Mustafa Pasha (1716)

open access: yesTürkiyat Mecmuası
During the reign of Süleiman the Magnificent, the Ottoman conquests were directed toward the west. The conquest of central Hungary by the Ottomans in particular was the beginning of a long struggle.
Bekir Gökpınar
doaj   +1 more source

The Introduction of the Austrian Toll System for Trucks - Effects on Companies

open access: yesCommunications, 2006
This paper deals with effects of the Austrian road pricing system on enterprises. Trucks are charged per kilometre driving on Austrian motorways with the amount depending on the number of axles.
Marcus Einbock
doaj   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

open access: yesFEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo   +7 more
wiley   +1 more source

Remote Assessment of Ataxia Severity in SCA3 Across Multiple Centers and Time Points

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Spinocerebellar ataxia type 3 (SCA3) is a genetically defined ataxia. The Scale for Assessment and Rating of Ataxia (SARA) is a clinician‐reported outcome that measures ataxia severity at a single time point. In its standard application, SARA fails to capture short‐term fluctuations, limiting its sensitivity in trials.
Marcus Grobe‐Einsler   +20 more
wiley   +1 more source

Construcción de índices de desempeño financiero mediante el Análisis de Componentes Principales, 2004-2005

open access: yesAnálisis Económico, 2007
El objetivo de esta investigación es aplicar el análisis factorial a un conjunto de variables financieras con características similares, de tal manera que sea posible identificar la estructura subyacente entre éstas mediante el resumen y la reducción de ...
Marco Antonio Austria Carlos
doaj  

Validity of a Wearable Digital Insole for Assessing Gait ON and OFF in Parkinson's Disease

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Gait impairment is a distinctive symptom of Parkinson's disease that negatively impact mobility. We assessed the validity of wearable digital insoles against a validated reference gait analysis system for measuring select gait characteristics in patients with Parkinson's disease. Methods A comparative analysis between digital insoles
Deborah A. Hall   +16 more
wiley   +1 more source

Los retos de la seguridad hídrica

open access: yesTecnología y ciencias del agua, 2013
La seguridad hídrica, definida como aquella que garantiza agua suficiente en calidad y cantidad para los diversos usos, a precios asequibles y en equidad, así como la protección de las personas y sus bienes ante fenómenos hidrometeorológicos extremos ...
Polioptro F. Martínez-Austria
doaj  

Seasonality of runoff and precipitation regimes along transects in Peru and Austria

open access: yesJournal of Hydrology and Hydromechanics, 2017
The aim of this study is to understand the seasonalities of runoff and precipitation and their controls along two transects in Peru and one transect in Austria. The analysis is based on daily precipitation data at 111 and 61 stations in Peru and Austria,
Gaudry Maria M. Cárdenas   +4 more
doaj   +1 more source

The Most Austrian Film Director. Notes on the Cinema of Willi Forst

open access: yesOpen Journal of Humanities, 2019
The present essay will discuss the work of Austrian film director Willi Forst. Active in Austria and Germany from the early 1930s to the end of the 1950s, Forst has been commonly regarded as one of the great names in the history of German-speaking cinema.
Francesco Bono
doaj   +1 more source

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