Results 41 to 50 of about 461,072 (266)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

open access: yesMolecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller   +10 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

The party and political landscape of Austria after the 2024 National Council elections

open access: yesНаучно-аналитический вестник Института Европы РАН
On September 29, 2024, elections to the National Council were held in Austria. According to their results, the extreme right-wing Austrian Freedom Party won the election with more than 28% of the votes.
Dmitry V. Shmelev, Egor E. Belyachkov
doaj   +1 more source

Auswirkungen des demografischen Wandels auf das Hochwasserrisikomanagement in Österreich: Relevanz und Empfehlungen aus der Perspektive von Expert*innen aus dem Gesundheits- und Sozialbereich

open access: yesDie Bodenkultur, 2021
Der demografische Wandel stellt eine komplexe Herausforderung für den territorialen und sozialen Zusammenhalt in unserer Gesellschaft dar. Dies deshalb, weil die Teilräume Österreichs in unterschiedlichem Maße von Veränderungen der Bevölkerungsgröße und ...
Fischer Tatjana   +4 more
doaj   +1 more source

CEACAM1 participation in breast cancer progression

open access: yesMolecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin   +3 more
wiley   +1 more source

Construcción de índices de desempeño financiero mediante el Análisis de Componentes Principales, 2004-2005

open access: yesAnálisis Económico, 2007
El objetivo de esta investigación es aplicar el análisis factorial a un conjunto de variables financieras con características similares, de tal manera que sea posible identificar la estructura subyacente entre éstas mediante el resumen y la reducción de ...
Marco Antonio Austria Carlos
doaj  

Learning from Quarantine with David Calas

open access: yesUrban Transcripts, 2020
One story per day, many questions for the days to come. For 40 days, from March 19th to April 27th 2020, David Calas, Sven Wuttej and Clemens Horvath of Studio Calas in Vienna, reflected on the changes that the pandemic forced upon the world and what ...
Giulia Carones, Yiorgos Papamanousakis
doaj  

On the eve of extraordinary election in the parliament of Austria: a background of the events [PDF]

open access: yesНаучно-аналитический вестник Института Европы РАН, 2019
The next parliamentary election in Austria is to be held on late September, 2019. This election is an extraordinary one, and that is a normal situation for this country. Austria often holds such extraordinary elections.
Vladimir Schweizer
doaj   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

open access: yesFEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo   +7 more
wiley   +1 more source

Institutions for Collective Gardening: A Comparative Analysis of 51 Urban Community Gardens in Anglophone and German-Speaking Countries

open access: yesInternational Journal of the Commons, 2020
Groups of urban gardeners collectively grow vegetables, fruits and flowers in an increasing number of community gardens all over the world. Despite a growing body of literature on community gardens, there is a particular gap for a transcontinental bigger
Ida Göttl, Marianne Penker
doaj   +1 more source

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