Results 31 to 40 of about 4,557,278 (245)

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Authentic E-Learning in higher education: Design principles for authentic learning environments and tasks [PDF]

, 2006
With many learners failing to engage with didactic and outmoded instructional methods, and unwilling to use technology that simply replicates the one-way transfer of information from teacher to student, authentic learning designs have the potential to ...
Herrington, J.
core  

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

MODEL OF ARABIC AUTHENTIC ASSESSMENT INSTRUMENTS: SPEAKING (KALĀM) AT MADRASAH ALIYAH

Alsinatuna, 2022
Authentic assessment is a model for assessing learning processes and outcomes that differ from ordinary assessments. Authentic judgment must be done in a natural context, not contrived, applied and taught.
Raswan, N. Lalah Alawiyah, Taufik Luthfi   +2 more
doaj   +1 more source

The Law School Degree Show: law, materiality, decolonisation and authentic assessment [PDF]

, 2023
For the final year Degree Show at Westminster Law School, all final year students are required to produce a material artefact that reflects on their understanding of law, justice, and their political and social responsibility as law students. In order to
Philippopoulos-Mihalopoulos, Andreas, Bunbury, S.   +1 more
core   +1 more source

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

Analisis bibliometrik perkembangan publikasi authentic assessment pada database scopus 1991 - 2023

Berkala Ilmu Perpustakaan dan Informasi
Introduction. Authentic assessment implementation faces challenges due to teachers' limited understanding and the absence of suitable assessment tools, leading to an unfair evaluation of students' cognitive, affective, and psychomotor skills. This study
Khoirul Amin, Zulfatun Ni’mah, Ari Susanto   +2 more
doaj   +1 more source

Designing authentic activities for web-based courses [PDF]

, 2002
Influenced by constructivist philosophy and advances in technology, there is increasing interest in authentic activities as a basis for learning in both face-to-face and web-based courses.
Herrington, J.
core