Results 91 to 100 of about 355,842 (292)
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
A new security architecture for SIP based P2P computer networks [PDF]
, 2008 Many applications are transferred from C/S (Client/Server) mode to P2P (Peer-to-Peer) mode such as VoIP (Voice over IP). This paper presents a new security architecture, i.e.
Tang, S, Yip, YJ, Yongfeng, H
core
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
The review of Extensible Authentication Protocol and its methods
Труды Института системного программирования РАН, 2018 Authentication is associated with a scenario, in which some party (the applicant) presented the identity of the principal and states that this is the principal.
A. V. Nikeshin, V. Z. Shnitman
doaj +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Keyless Authentication and Authenticated Capacity
IEEE Transactions on Information Theory, 2018 We consider the problem of keyless message authentication over noisy channels in the presence of an active adversary. Different from the existing models, in our model, the legitimate users do not have any pre-shared key for authentication. Instead, we use the noisy channel connecting the legitimate users for authentication.
Wenwen Tu, Lifeng Lai
openaire +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
A Novel Protocol Using Captive Portals for FIDO2 Network Authentication
Applied SciencesFIDO2 authentication is starting to be applied in numerous web authentication services, aiming to replace passwords and their known vulnerabilities. However, this new authentication method has not been integrated yet with network authentication systems ...
Martiño Rivera-Dourado +3 more
doaj +1 more source