Results 81 to 90 of about 355,842 (292)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Reliable and Cost-Effective QuEChERS–UHPLC–MS/MS Method for the Simultaneous Analysis of Ten Mycotoxins in Dendrobium Officinale: A Study on Food-Medicine Homology Quality Control

Journal of Analytical Methods in Chemistry
This study developed a method for simultaneously detecting 10 mycotoxins in Dendrobium officinale using the QuEChERS technique combined with ultra-high-performance liquid chromatography–tandem mass spectrometry (UHPLC–MS/MS). The method was optimized for
Zejun Wang, Qingcheng Wang, Fei Xu, Linhua Wang, Jingjing Liang, Qing Shen, Shunyuan Guo   +6 more
doaj   +1 more source

Secure Secondary Authentication Framework for Efficient Mutual Authentication on a 5G Data Network

Applied Sciences, 2020
The service-based architecture of the Fifth Generation(5G) had combined the services and security architectures and enhanced the authentication process of services to expand the coverage of the network, including heterogeneous devices.
Seonghyeon Gong, Abir EL Azzaoui, Jeonghun Cha, Jong Hyuk Park   +3 more
doaj   +1 more source

Authenticity, authentication and experiential authenticity: telling stories in museums [PDF]

Social & Cultural Geography, 2018
This article examines how different types of authenticity and authentication work together to inspire museum stories, and personal identification with them, in ways that encourage experiential authenticity. It begins by outlining conceptions of object and existential authenticity and demonstrating how they are bound up with processes of hot and cool ...
openaire   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Natural polysaccharides as promising reno-protective agents for the treatment of various kidney injury

Pharmacological Research
Renal injury, a prevalent clinical outcome with multifactorial etiology, imposes a substantial burden on society. Currently, there remains a lack of effective management and treatments.
Yufei Ye, Maoting Li, Wei Chen, Hongrui Wang, Xuhui He, Nanmei Liu, Zhiyong Guo, Chengjian Zheng   +7 more
doaj   +1 more source

Fast Authentication in Heterogeneous Wireless Networks [PDF]

, 2005
The growing diffusion of wireless devices is leading to an increasing demand for mobility and security. At the same time, most applications can only tolerate short breaks in the data flow, so that it is a challenge to find out mobility and authentication
Albertengo, Guido, Pastrone, C., Tolu, G.   +2 more
core  

Fuzzy Authentication using Rank Distance

, 2017
Fuzzy authentication allows authentication based on the fuzzy matching of two objects, for example based on the similarity of two strings in the Hamming metric, or on the similiarity of two sets in the set difference metric.
A Cossidente, A Juels, A Kshevetskiy, D Schipani, D Silva, EM Gabidulin, J Cruz de la, J Sheekey, R Roth   +8 more
core   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

The mechanism and clinical significance of FKBP5 gene DNA methylation in various psychiatric, metabolic and tumor-related diseases

Frontiers in Genetics
The FK506 Binding Protein 5 (FKBP5) gene encodes a protein that binds to the immunosuppressive agent FK506. FKBP5 expression is regulated by genetic variation and epigenetic mechanisms, including DNA methylation (DNAm).
Changliang Wang, Zhixiu Xia
doaj   +1 more source