Results 71 to 80 of about 55,577 (266)
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Pharmacological ResearchRenal injury, a prevalent clinical outcome with multifactorial etiology, imposes a substantial burden on society. Currently, there remains a lack of effective management and treatments.
Yufei Ye +7 more
doaj +1 more source
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
Frontiers in GeneticsThe FK506 Binding Protein 5 (FKBP5) gene encodes a protein that binds to the immunosuppressive agent FK506. FKBP5 expression is regulated by genetic variation and epigenetic mechanisms, including DNA methylation (DNAm).
Changliang Wang, Zhixiu Xia
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Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Language and Authenticity [PDF]
Journal for the Theory of Social Behaviour, 1997 It is argued that the analysis of language should play a central role in the study of social psychological phenomenon. For example, there is evidence that habitual inauthenticity in the use of language which was practised in the Eastern and Central European totalitarian systems was partly related to the breakdown of moral principles and to the loss of ...
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Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
The review of Extensible Authentication Protocol and its methods
Труды Института системного программирования РАН, 2018 Authentication is associated with a scenario, in which some party (the applicant) presented the identity of the principal and states that this is the principal.
A. V. Nikeshin, V. Z. Shnitman
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The journey to authenticity: solicitations for authentic leadership
Formazione & Insegnamento, 2014 The purpose of this paper is to investigate the construct of authentic leadershipb from a conceptual analysis involving contributions from the management literature and studies in education. It is our belief that such an approach will help us raise moral and ethical questions leading to a better understanding of the needs facing the world today.
Bezzina, Christopher +1 more
openaire +3 more sources