Results 51 to 60 of about 501,268 (227)
Higgs boson and the Cosmos: A philosophical reappraisal of the authoritative Catholic and Greek-Orthodox perspectives [PDF]
, 2019 The theoretical prediction of Higgs boson was arguably one of the most important contributions in particle physics in the 20th century, with significant implications for modern cosmology.
Kilakos, Dimitris
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A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
FOCUSED ON THEIR FAMILIES: Religion, Parenting, & Child Well-being [PDF]
In recent years, scholars have drawn attention to religious commitments to patriarchy and parental authority to argue that religion—especially conservative Protestantism—fosters an authoritarian approach to parenting. Indeed, using data from the National
W. Bradford Wilcox
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Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Making Sense of Desegregation and Affirmative Action [PDF]
, 1979 This review discusses J. Harvie Wilkinson\u27s From Brown to Bakke and its companion work, Counting by Race: Equality from the Founding Fathers to Bakke and Weber written by Terry Eastland and William J. Bennett.
Van Alstyne, William W.
core +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Canada and the First World War: A Canadian War Museum Internet Exhibition [PDF]
, 2012 Canada and the First World War is the largest internet resource ever developed by the Canadian War Museum. The goal of this site is to provide visitors across the country and around the world with the most comprehensive and authoritative site for the ...
Cook, Tim, Lyons, Kathryn
core +1 more source