Results 41 to 50 of about 55,265 (302)

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

open access: yesMolecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge   +17 more
wiley   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

open access: yesMolecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel   +6 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Blockchain-Based Multi-Party Authorization for Accessing IPFS Encrypted Data

open access: yesIEEE Access, 2020
Multi-party authorization (MPA) typically involves multiple parties to control and grant access to shared data. MPA is used to solve the insider's attack problem by ensuring that a single authority or party is not acting alone.
Ammar Ayman Battah   +5 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Querying OCLC Web Services for Name, Subject, and ISBN

open access: yesCode4Lib Journal, 2010
Using Web services, search terms can be sent to WorldCat's centralized authority and identifier files to retrieve authorized terminology that helps users get a comprehensive set of relevant search results.
Ya’aqov Ziso   +2 more
doaj  

La LC classification come linked data

open access: yesJLIS.it, 2013
In 2009 and in 2011, the Library of Congress made two of its largest authority files – Subject Headings and Names – available as linked data via LC’s Linked Data Service, ID.LOC.GOV. Both are offered in MADS/RDF and SKOS.
Kevin Ford
doaj   +1 more source

Censorship Files Regarding the Three First Novels of José Jiménez Lozano

open access: yesAnuario de Estudios Filológicos, 2020
The present study analyses the arbitrariness of censorship during Franco's regime. It is pointed out how the works of José Jiménez Lozano are a challenge to the censorship principles: the stories show the consequences of using authority as a deterrent of
Guadalupe Arbona Abascal
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

open access: yesMolecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic   +5 more
wiley   +1 more source

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