Results 61 to 70 of about 55,265 (302)
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Australia’s future emissions reduction targets [PDF]
, 2015 Presents the Climate Change Authority\u27s recommendations on Australia\u27s future emissions reduction targets, and constitutes the first part of the Authority\u27s response to the Special Review requested by the Minister for the Environment in December
Climate Change Authority
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Parsing and Matching Dates in VIAF
Code4Lib Journal, 2014 The Virtual International Authority File (OCLC Online Computer Library Center 2013) http://viaf.org is built from dozens of authority files with tens of millions of names in more than 150 million authority and bibliographic records expressed in multiple ...
Jenny A. Toves, Thomas B. Hickey
doaj
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
o-bib. Das offene Bibliotheksjournal, 2014 Normdateien lösen das Problem von unterschiedlichen Namensschreibweisen, Übersetzungen und Namensdoppelungen. Nationale oder an Sprachräume gebundene Normdaten sind mittlerweile im "International Authority File“ Projekt (VIAF) über Konkordanzen ...
Martin Faßnacht
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Proceedings of the New Jersey Turnpike Authority - May 25, 2021
, 2021 Downloaded from: https://www.njta.com/board-agendas-minutes/agenda-center?daterangePicker=&Keyword=&year=&page=20 Agenda and minutes (called Proceedings) are in separate ...
New Jersey. Turnpike Authority
core
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
Authority control from the past to the future: is the present agreeing on international cooperation
Knjižnica, 2002 Slovenian plans for transferring the existing card authority file into an automated one may serve as a starting point to rethink the concept of the catalogue in general.
Zlata Dimec
doaj +1 more source