Results 71 to 80 of about 721,453 (300)
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Tshekedi Khama papers : covering dates: 1889 - 1997 [PDF]
, 2010 This collection comprises 10 linear metres of the papers of Tshekedi Khama (1905-1959), Regent of the Bangwato Tribe, and uncle of Seretse Khama.
University of Botswana, Archives
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Dressing and addressing the mental patient: the uses of clothing in the admission, care and employment of residents in English provincial mental hospitals, c. 1860–1960 [PDF]
, 2014 Scholars of insanity and its historical antecedents have paid very little attention to personal and institutional clothing. Such dress, distributed to patients in mental institutions, has always been inscribed with the conflicting narratives of the ...
Baur, Nicole, Melling, Joseph
core +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
An Analytical Study of the Reality of Electronic Documents and Electronic Archiving in the Management of Electronic Documents in the Palestinian Pension Agency (PPA) [PDF]
, 2017 The study aims to identify the reality of management of electronic documents and electronic archiving retirement in the Palestinian Pension Agency -analytical study, as well as to recognize the reality of the current document management system in the ...
Abu Naser, Samy S. +2 more
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Molecular Oncology, EarlyView.Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard +5 more
wiley +1 more source
o-bib. Das offene Bibliotheksjournal, 2014 Normdateien lösen das Problem von unterschiedlichen Namensschreibweisen, Übersetzungen und Namensdoppelungen. Nationale oder an Sprachräume gebundene Normdaten sind mittlerweile im "International Authority File“ Projekt (VIAF) über Konkordanzen ...
Martin Faßnacht
doaj +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
Authority control from the past to the future: is the present agreeing on international cooperation
Knjižnica, 2002 Slovenian plans for transferring the existing card authority file into an automated one may serve as a starting point to rethink the concept of the catalogue in general.
Zlata Dimec
doaj +1 more source