Results 71 to 80 of about 2,231,436 (329)

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

open access: yesFEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman   +2 more
wiley   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham   +21 more
wiley   +1 more source

Parsing and Matching Dates in VIAF

open access: yesCode4Lib Journal, 2014
The Virtual International Authority File (OCLC Online Computer Library Center 2013) http://viaf.org is built from dozens of authority files with tens of millions of names in more than 150 million authority and bibliographic records expressed in multiple ...
Jenny A. Toves, Thomas B. Hickey
doaj  

David Stafford-Clark (1916-1999): seeing through a celebrity psychiatrist [PDF]

open access: yes, 2017
This article uses the mass-media career of the British psychiatrist David Stafford-Clark (1916-1999) as a case study in the exercise of cultural authority by celebrity medical professionals in post-war Britain.
Miller, Gavin
core   +2 more sources

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

open access: yesMolecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan   +9 more
wiley   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira   +14 more
wiley   +1 more source

The Failure of Federal Biotechnology Regulation [PDF]

open access: yes, 2017
The recent court case and state ballot measures regarding mandatory labels for Genetically Modified Organisms (“GMOs”) suggest the need for a deeper conversation about the federal framework for regulating biotechnology.
Peck, Alison
core   +1 more source

The step project:societal and political engagement of young people in environmental issues [PDF]

open access: yes, 2017
Decisions on environmental topics taken today are going to have long-term consequences that will affect future generations. Young people will have to live with the consequences of these decisions and undertake special responsibilities.
Apostolidis, Lazaros   +10 more
core   +2 more sources

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

open access: yesMolecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath   +13 more
wiley   +1 more source

„Druckt die GND Nummer in der Publikation ab!“ Vereinfachung der Normdatenverwendung in Bibliotheken und Datenbanken

open access: yeso-bib. Das offene Bibliotheksjournal, 2014
Normdateien lösen das Problem von unterschiedlichen Namensschreibweisen, Übersetzungen und Namensdoppelungen. Nationale oder an Sprachräume gebundene Normdaten sind mittlerweile im "International Authority File“ Projekt (VIAF) über Konkordanzen ...
Martin Faßnacht
doaj   +1 more source

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