Results 81 to 90 of about 2,231,436 (329)
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
Model All-Payer Claims Database Legislation [PDF]
, 2015 With support from the Gary and Mary West Health Policy Center, the APCD Council has developed model legislation guidance for states to develop all-payer claims database ...
Hodder, Lucy C. +3 more
core +2 more sources
Molecular Oncology, EarlyView.Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser +14 more
wiley +1 more source
Authority control from the past to the future: is the present agreeing on international cooperation
Knjižnica, 2002 Slovenian plans for transferring the existing card authority file into an automated one may serve as a starting point to rethink the concept of the catalogue in general.
Zlata Dimec
doaj +1 more source
, 2009 The Buffalo Sewer Authority is a public benefit corporation created by the New York State legislature in 1935 to clean wastewater before it is released into the environment. The BSA also maintains the storm drains for the City of Buffalo.
Vogan, Eric
core +1 more source
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
All different, all equal: changing basic principles of the authority control
Knjižnica, 2001 To enable the collocation function of the catalogue, the uniform heading was introduced by the Paris Principles, and later on became one of the key elements for the Universal Bibliographic Control project.
Zlata Dimec
doaj +1 more source
The Politics of Hydroelectric Power in Alaska: Rampart and Devil Canyon -- A Case Study [PDF]
, 1978 Originally published January 1978, revised October 1978. OWRT Agreement No. 14-34-0001-7003 Project No. A-060-ALAS. Completion Report.Hydroelectric power in Alaska has had a curious history--and an instructive one.
Hunt, William R., Naske, Claus-M.
core
Molecular Oncology, EarlyView.This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad +17 more
wiley +1 more source