Results 111 to 120 of about 251,382 (296)
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
An Innovative Workspace for The Cherenkov Telescope Array [PDF]
, 2016 The Cherenkov Telescope Array (CTA) is an initiative to build the next generation, ground-based gamma-ray observatories. We present a prototype workspace developed at INAF that aims at providing innovative solutions for the CTA community.
Becciani, Ugo +6 more
core +1 more source
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
Consent in Data Privacy: A General Comparison of GDPR and HIPAA
Przegląd Prawniczy Uniwersytetu im. Adama MickiewiczaThe purpose of this paper is to conduct a general comparisonof legal requirements regarding consent under the Health Insurance Portability and Accountability Act (HIPAA) and the General Data Protection Regulation (GDPR).
Magdalena Jurczuk, Maria Suprunowicz
doaj +1 more source
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
CPT: Pharmacometrics & Systems PharmacologyWe present here a repository of key regulatory questions answered in centralized procedures and evaluate the place of modeling and simulation in marketing authorization process for biologics approved for the treatment of moderate‐to‐severe asthma from ...
Hélène Haguet +2 more
doaj +1 more source
Privacy-Preserving EV Charging Authorization and Billing via Blockchain and Homomorphic Encryption
World Electric Vehicle JournalElectric vehicle (EV) charging infrastructures raise significant concerns about data security and user privacy because traditional centralized authorization and billing frameworks expose sensitive information to breaches and profiling.
Amjad Aldweesh, Someah Alangari
doaj +1 more source
The Labor Movement’s Framework for Comprehensive Immigration Reform [PDF]
, 2009 [Excerpt] Immigration reform is a component of a shared prosperity agenda that focuses on improving productivity and quality; limiting wage competition; strengthening labor standards, especially the freedom of workers to form unions and bargain ...
AFL-CIO, Change To Win
core +1 more source
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source