Results 191 to 200 of about 251,382 (296)

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Regulatory Performance of African National Medicines Regulatory Authorities Achieving WHO Maturity Level 3: Identifying Best Practices. [PDF]

Ther Innov Regul Sci
Owusu-Asante M, Darko DM, Semete-Makokotieia B, Adeyeye CM, Fimbo AM, Rukwata R, Zaki G, Walker S, Salek S.   +8 more
europepmc   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

India's Unique Legal Framework for Psilocybin Mushroom Research: An Unprecedented Opportunity in Psychiatric Therapeutics. [PDF]

Indian J Psychol Med
Tom A, Reddy BSC, Sethi MIS, Math SB.
europepmc   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Regulation of phage therapy medicinal products: developments, challenges, and opportunities. [PDF]

Front Cell Infect Microbiol
Fuerst-Wilmes M, Respondek V, Schramm M, Lilienthal N, Buss K, Duechting A.   +5 more
europepmc   +1 more source

Authorization-enhanced security framework for OGSA support.

, 2003
Security plays an important role for a large distributed system in an open community. Without enough knowledge about the user, it is hard to make access decision to the local resources. Current Public Key Infrastructure (PKI) uses a trusted third party, called Certificate Authority (CA), to check the identity of the users. The assumption of PKI is that
openaire   +2 more sources

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Advancing Compliance with HIPAA and GDPR in Healthcare: A Blockchain-Based Strategy for Secure Data Exchange in Clinical Research Involving Private Health Information. [PDF]

Healthcare (Basel)
Barbaria S, Jemai A, Ceylan Hİ, Muntean RI, Dergaa I, Boussi Rahmouni H.   +5 more
europepmc   +1 more source