Results 81 to 90 of about 252,498 (298)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Multilayered Framework to Enhance Management Information Systems Decision on Sensitive Data in Cloud Computing Environment

JOIV: International Journal on Informatics Visualization, 2017
The purpose of this research is defining the main factors influencing on decision of management system on sensitive data in cloud. The framework is proposed to enhance management information systems decision on sensitive information in cloud environment.
Haifaa Jassim Muhasin, Rodziah Atan, Marzanah A.Jabar, Salfarina Abdullah, Shahreen Kasim   +4 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Account hijacking threat attack detection for OAuth2.0 authorization API

Tongxin xuebao, 2019
OAuth2.0 protocol has been widely adopted to simplify user login to third-party applications,at the same time,existing risk of leaking user privacy data,what even worse,causing user accounts to be hijacked.An account hijacking attack model around ...
Qixu LIU, Kaili QIU, Yiwen WANG, Yanhui CHEN, Langping CHEN, Chaoge LIU   +5 more
doaj   +2 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Citizen Electronic Identities using TPM 2.0

, 2014
Electronic Identification (eID) is becoming commonplace in several European countries. eID is typically used to authenticate to government e-services, but is also used for other services, such as public transit, e-banking, and physical security access ...
Asokan, N., Ekberg, Jan-Erik, Nyman, Thomas   +2 more
core   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Putting the substance in substantial evidence: an evidence-based approach to flexible drug regulation

Frontiers in Medicine
For new drugs or indications, substantial evidence of clinical effectiveness is required for market authorization. In most jurisdictions, substantial evidence is not explicitly defined.
Emanuel Krebs, Tania Bubela, Melanie McPhail, Christopher McCabe, Dean A. Regier, Dean A. Regier   +5 more
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

THE IMPACT OF AUTHORIZATION IN THE ASSESSMENT OF RISKS AND SAFETY MEASURES OF OVERSIZED TRANSPORT ACTIVITY

Journal of Social Sciences
The article aims to analyze the regulations and regulatory framework regarding the authorization of oversized transport, highlighting their importance in ensuring road safety and protecting the infrastructure.
GARSTEA, Nina
doaj   +1 more source