Results 201 to 210 of about 5,339,872 (258)

Psychometric Properties of the Korean Version of the Glasgow Sleep Effort Scale in the General Population and Among Individuals Reporting Insomnia. [PDF]

Psychiatry Investig
Chung S, Sleiman J, Shahrier MA.
europepmc   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Comparison of Comprehensive Serum miRNA Sequencing and Apolipoprotein A2 Isoforms for Early Detection of Pancreatic Cancer. [PDF]

Cancers (Basel)
Kashima H, Kawai M, Iimori K, Nagao M, Morikawa TJ, Otomo R, Hirai M, Minaga K, Asada M, Umemura A, Uenoyama Y, Morita T, Yazumi S, Minami R, Marui S, Yamauchi Y, Nakai Y, Takada Y, Shio S, Yoshioka T, Kanda N, Masuda T, Nagai K, Hatano E, Fukuda A, Seno H.   +25 more
europepmc   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Different Behavioral Measures of Conditioned Magazine Activity Can Tell Different Stories about Brain Function. [PDF]

eNeuro
Volz SG, Loewinger G, Marquez I, Fevola S, Kang M, Reverte I, Krishnan A, Gardner MPH, Iordanova MD, Esber GR.   +9 more
europepmc   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Development and validation of a multiparameter prognostic model for extranodal natural killer/T-cell lymphoma: Integration of clinical, pathological, and molecular biomarkers. [PDF]

Cytojournal
Wu S, Liu Y, Jiang L, An L, Zhang Y, Pan Y, Song L, Wang Y, Yu G.   +8 more
europepmc   +1 more source

Index of authors

Central and Eastern European eDem and eGov Days, 2018
openaire   +2 more sources

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Prognostic value of the triglyceride-glucose index in patients with acute ischemic stroke undergoing endovascular treatment. [PDF]

J Int Med Res
Yang K, Xu Q, Peng X, Xu X, Guo Y, Xu J.
europepmc   +1 more source