Results 71 to 80 of about 2,345,404 (292)

Gut‐Liver Translocation of Bacteroides Uniformis Alleviates Advanced Metabolic Dysfunction‐Associated Steatotic Liver Disease by Suppressing Hepatocyte Ferroptosis via Propionic Acid Secretion

Advanced Science, EarlyView.
Systematic characterization of the liver‐resident microbiota in advanced metabolic dysfunction‐associated steatotic liver disease (MASLD) reveals a consistent depletion of Bacteroides uniformis (B. uniformis) in both hepatic and gut microbial communities. Oral gavage of B.
Haiyang Liu, Zun Fan, Zhen Liu, Lei Qin, Xin Zhao   +4 more
wiley   +1 more source

SemanticST: A Scalable Multi‐Contextual Graph Learning Framework for Uncovering Spatial Niches and Robust Multi‐Sample Integration in Spatial Transcriptomics

Advanced Science, EarlyView.
Technical limitations often let dominant signals overshadow rare cell types and fine‐grained heterogeneity in spatial transcriptomics. SemanticST, a graph neural network using multi‐semantic graph fusion and a novel min‐cut loss, recovers these subtle patterns.
Roxana Zahedi, Ahmadreza Argha, Nona Farbehi, Ivan Bakhshayeshi, Thantrira Porntaveetus, Youqiong Ye, Nigel H. Lovell, Hamid Alinejad‐Rokny   +7 more
wiley   +1 more source

Structural alterations of the social brain: a comparison between schizophrenia and autism. [PDF]

PLoS ONE, 2014
Autism spectrum disorder and schizophrenia share a substantial number of etiologic and phenotypic characteristics. Still, no direct comparison of both disorders has been performed to identify differences and commonalities in brain structure.
Daniel Radeloff, Angela Ciaramidaro, Michael Siniatchkin, Daniela Hainz, Sabine Schlitt, Bernhard Weber, Fritz Poustka, Sven Bölte, Henrik Walter, Christine Margarete Freitag   +9 more
doaj   +1 more source

Understanding autism: insights from mind and brain [PDF]

, 2003
Autism is a developmental disorder characterized by impaired social interaction and communication as well as repetitive behaviours and restricted interests. The consequences of this disorder for everyday life adaptation are extremely variable.
Hill, E.L., Frith, U., Hill, Elisabeth L., Uta Frith, Frith, Uta, Elisabeth L. Hill   +5 more
core   +1 more source

Molecular Glue Degraders Enhance CAPRIN1‐Dependent Lysosomal Degradation of APP and Reduce Amyloid β in Alzheimer's Disease

Advanced Science, EarlyView.
A new class of lysosome‐directed molecular glue degraders selectively enhance CAPRIN1–APP interactions, driving APP degradation and reducing amyloid‐β production in human neurons and Alzheimer's disease mouse models. This CAPRIN1‐dependent targeted protein degradation strategy reveals a previously unrecognized therapeutic approach for disrupting the ...
Sunghan Jung, Xu Wang, Bin Liu, Raktim Roy, Nancy Jaiswal, Ratan K. Rai, Yuichiro Takagi, Cen Gao, Lifan Zeng, Ho‐Yin Lo, Reagan K. Wohlford, Ryan K. Higgins, Bruce T. Lamb, Anantha Shekhar, Anita C. Bellail, Chunhai Hao   +15 more
wiley   +1 more source

Common polygenic risk for autism spectrum disorder (ASD) is associated with cognitive ability in the general population [PDF]

, 2015
Cognitive impairment is common among individuals diagnosed with autism spectrum disorder (ASD) and attention-deficit hyperactivity disorder (ADHD). It has been suggested that some aspects of intelligence are preserved or even superior in people with ASD ...
Starr, J., D J Porteous, Hocking, L J, Porteous, D. J., Thomson, P A; id_orcid, Hocking, L. J., Davies, G., Medland, S E, S E Medland, Hocking, L.J., Wright, M.J., Porteous, D J, J Starr, Lupton, M. K., Hall, L.S., Montgomery, G W, Clarke, T.-K., Medland, S.E., Pattie, A., Martin, N.G., Liewald, D.C., Padmanabhan, S., Deary, I J, C Hayward, Smith, B.H., Hall, L S, Smith, B. H.; id_orcid, Fernandez-Pujals, A. M., Wright, M J, G W Montgomery, Hansell, N K, D C Liewald, Hall, L. S., N K Hansell, Wright, M. J., N G Martin, Hayward, C., S Cox, Liewald, D. C., Cox, S., Starr, J, Montgomery, G. W., I J Deary, Thomson, P. A., B H Smith, Deary, I. J., Fernandez-Pujals, A M, Lupton, M K, Hayward, C; id_orcid, M K Lupton, Davies, Gail, P A Thomson, Clarke, T-K, A M McIntosh, Hansell, N. K., Hansell, N.K., MacIntyre, D J; id_orcid, MacIntyre, D. J., L J Hocking, Smith, B. H., Cox, S, Fernandez-Pujals, A.M., Thomson, P.A., McIntosh, A M; id_orcid, M J Wright, Martin, N. G., Porteous, D.J., G Davies, Montgomery, G.W., Smith, B H, A M Fernandez-Pujals, McIntosh, A. M., A Pattie, D J MacIntyre, McIntosh, A.M., Clarke, T. K., S Padmanabhan, Medland, S. E., Pattie, A, Liewald, D C, L S Hall, Lupton, M.K., T-K Clarke, Padmanabhan, S, Martin, N G, MacIntyre, D.J., Deary, I.J.   +86 more
core   +1 more source

Automating AI Discovery for Biomedicine Through Knowledge Graphs and Large Language Models Agents

Advanced Intelligent Discovery, EarlyView.
This work proposes a novel framework that automates biomedical discovery by integrating knowledge graphs with multiagent large language models. A biologically aligned graph exploration strategy identifies hidden pathways between biomedical entities, and specialized agents use this pathway to iteratively design AI predictors and wet‐lab validation ...
Naafey Aamer, Muhammad Nabeel Asim, Shan Munir, Andreas Dengel   +3 more
wiley   +1 more source

A Review on Recent Trends of Bioinspired Soft Robotics: Actuators, Control Methods, Materials Selection, Sensors, Challenges, and Future Prospects

Advanced Intelligent Systems, Volume 7, Issue 3, March 2025.
This article reviews the current state of bioinspired soft robotics. The article discusses soft actuators, soft sensors, materials selection, and control methods used in bioinspired soft robotics. It also highlights the challenges and future prospects of this field.
Abhirup Sarker, Tamzid Ul Islam, Md. Robiul Islam   +2 more
wiley   +1 more source

Sleep Disturbances in Adults With Tuberous Sclerosis Complex: Influences of Treatment and Clinical Features

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Tuberous sclerosis complex (TSC) is a genetic condition with multisystem neurocutaneous signs, including hamartomas, epilepsy, and neuropsychological difficulties. Although sleep disorders are increasingly recognized in TSC, they remain poorly described in adults.
Kirstin A. Risgaard, Laura Farach, Hope Northrup, Sarah L. Wilson, Deborah Pearson, Syed Hashmi, Kate Richardson   +6 more
wiley   +1 more source

COGNITIVE SKILLS IN HEARING-IMPAIRED PEOPLE: RELATIONSHIP BETWEEN THEORY OF MIND AND ATTENTION

IBRO Neuroscience Reports, 2023
Mohammad Rezaei, Hoorieh Darvishi
doaj   +1 more source