Results 41 to 50 of about 710,516 (276)

Targeting Aberrant RAS/RAF/MEK/ERK Signaling for Cancer Therapy

Cells, 2020
The RAS/RAF/MEK/ERK (MAPK) signaling cascade is essential for cell inter- and intra-cellular communication, which regulates fundamental cell functions such as growth, survival, and differentiation.
Ufuk Degirmenci, Mei Wang, Jiancheng Hu
doaj   +1 more source

Solid Harmonic Wavelet Bispectrum for Image Analysis

Advanced Science, EarlyView.
The Solid Harmonic Wavelet Bispectrum (SHWB), a rotation‐ and translation‐invariant descriptor that captures higher‐order (phase) correlations in signals, is introduced. Combining wavelet scattering, bispectral analysis, and group theory, SHWB achieves interpretable, data‐efficient representations and demonstrates competitive performance across texture,
Alex Brown, Mathilda Avirett‐Mackenzie, Carolin Villforth, Georgios Exarchakis   +3 more
wiley   +1 more source

Dynamic modeling of Terahertz Quantum cascade lasers [PDF]

, 2011
In this paper, the influence of the simplifications made in the four-equation-based set of rate equations describing the dynamic behavior of a Quantum Cascade Laser (QCL) is studied.
Petitjean, Yoann, Destic, Fabien, Mollier, Jean-Claude, Sirtori, Carlo   +3 more
core   +1 more source

Sustainable Materials Design With Multi‐Modal Artificial Intelligence

Advanced Science, EarlyView.
Critical mineral scarcity, high embodied carbon, and persistent pollution from materials processing intensify the need for sustainable materials design. This review frames the problem as multi‐objective optimization under heterogeneous, high‐dimensional evidence and highlights multi‐modal AI as an enabling pathway.
Tianyi Xu, Tianshuo Wei, Yan Ge, Bo Peng, Yue Li, Maolin Wang, Peng Wen, Chao Yang, Ye Wei   +8 more
wiley   +1 more source

Ferroelectric Devices for In‐Memory and In‐Sensor Computing

Advanced Science, EarlyView.
Inspired by biological systems, in‐memory and in‐sensor computing overcome von Neumann bottlenecks. Ferroelectric devices can mimic synaptic functions and sense stimuli like light or force, therefore are ideal for these paradigms. This review introduces the ferroelectric devices applied for in‐memory and in‐sensor computing, covering their structures ...
Hong Fang, Ronghuan Xie, Qiang Cao, Shishen Yan, Xiaolin Wang, Limei Zheng   +5 more
wiley   +1 more source

Experimental optimization and evaluation of an R600a/R1150 auto-cascade refrigeration systems for ultra-low temperature applications

Results in Engineering
Auto-cascade refrigeration systems are the most employed systems for ultra-low temperature applications, especially for small capacity systems. Recent investigations have allowed to analyze them energetically and thermodynamically, starting a research ...
Manel Martínez-Ángeles, Daniel Calleja-Anta, Laura Nebot-Andrés, Rodrigo Llopis   +3 more
doaj   +1 more source

Theoretical gas phase compressibility factor of mixed refrigerants in auto-cascade refrigeration system [PDF]

Proceedings of the 5th International Conference on Advanced Design and Manufacturing Engineering, 2015
KEYWORD: auto -cascade; mixed refrigerants; gas phase compressibility factor; ratio of refrigerant ABSTRACT: The compressibility factor is solved using the RKS equation and the corresponding calculation program. Redlich-kwongSoave the numerical calculation method for solving the compressibility factor, R22 and CO2 is calculated and compare it with ...
Jie Li, Xiang Li, Hai-Feng Yu, Shuo Chen, Qiu-Yan Chen, Li-Ping Gao, Lei Liu, Da-Yu Zheng   +7 more
openaire   +1 more source

Aberrant GRP78 Phase Transition Sustains Endothelial IRE1α Signaling and Drives Blood–Brain Barrier Failure in Cerebral Amyloid Angiopathy

Advanced Science, EarlyView.
Vascular Aβ40 corrupts GRP78 phase behavior in brain endothelial cells, sustaining IRE1α–TRAF2–JNK signaling and driving apoptosis, tight junction loss, and blood–brain barrier failure in cerebral amyloid angiopathy. Pharmacological IRE1α inhibition restores vascular integrity, reduces leakage, and improves functional outcomes, revealing a targetable ...
Honglin Zheng, Qiang Li, Haiyang Luo, Yapei Yuan, Na Zhang, Yongting Lu, Suying Duan, Jieshi Zhong, Hang Zhang, Chenyang Liu, Yaochong Zhang, Wenzhuo Zhao, Yaxuan Song, Tuo Wang, Si Yan, Yapeng Li, Han Liu, Yuan Gao, Zongping Xia, Yuming Xu   +19 more
wiley   +1 more source

Vapor Compression Refrigeration System for Aircrafts: Current Status, Large-Temperature-Range Challenges and Emerging Auto-Cascade Refrigeration Technologies

Aerospace
Modern aircraft increasingly utilizes highly integrated electronic equipment, driving continuously increasing heat dissipation demands. Vapor compression refrigeration systems demonstrate stronger alignment with future aircraft thermal management trends,
Hainan Zhang, Qinghao Wu, Shuo Feng, Sujun Dong, Zanjun Gao   +4 more
doaj   +1 more source

Genetic Ablation and Multi‐Omics Profiling Reveal CEP55 as a Key Driver of Tumorigenesis in Diverse Cancer Models

Advanced Science, EarlyView.
Genetic ablation of Cep55 in Pten‐deficient mouse models delays tumorigenesis. Integrated multi‐omics analyses (proteomics, phosphoproteomics, and spatial transcriptomics) reveal that CEP55 regulates oncogenic signaling (RAS/ERK, PI3K/AKT), integrin/FAK‐mediated adhesion, extracellular matrix (ECM) remodeling, and endocytosis.
Behnam Rashidieh, Yuanhao Yang, Amanda Louise Bain, Phillip Theron, Catharina Vosloo, Sahar Keshvari, Parinaz Ahangar, Brydie Bowden, Simon M. Tria, Ben B. Wang, Sandra Isenmann, Nicholas J. Westra van Holthe, Zherui Xiong, Hani Vu, Sowmya Sharma, Asmerom Sengal, J. Alejandro Lopez, John Finnie, Antonella Papa, Pascal H.G. Duijf, Quan Nguyen, Pirjo M. Apaja, Kum Kum Khanna   +22 more
wiley   +1 more source