Results 41 to 50 of about 863,741 (284)

Job-queuing and Auto-scaling in Container-based Cloud Environments [PDF]

open access: yes, 2018
Many applications process large quantities of data that takes significant time and requires big amount of compu- tational resources. Optimising the execution of such applications in a cloud computing environment by keeping costs at minimum but still ...
Kiss, T., Abu Oun, O.
core  

Liver organoids: modelling complexity in homeostasis and disease

open access: yesFEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

A STACKED GENERALIZATION BASED META-CLASSIFIER FOR PREDICTION OF CLOUD WORKLOAD [PDF]

open access: yesICTACT Journal on Soft Computing
Cloud computing has revolutionized the way software, platforms, and infrastructure can be acquired by making them available as on-demand services that can be accessed from anywhere via a web browser.
Sanjay T. Singh, Mahendra Tiwari
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

open access: yesMolecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary   +1 more
wiley   +1 more source

Physical ageing from generalised time-translation-invariance

open access: yesNuclear Physics B
A generalised form of time-translation-invariance permits to re-derive the known generic phenomenology of ageing, which arises in classical many-body systems after a quench from an initially disordered system to a temperature T≤Tc, at or below the ...
Malte Henkel
doaj   +1 more source

Proactive Auto-Scaling Approach of Production Applications Using an Ensemble Model

open access: yesIEEE Access, 2023
The resource usage behaviors of application workloads are currently the primary concern of cloud providers offering hosting services. These services should be able to adapt to workload changes by automatically provisioning and de-provisioning resources ...
Mohamed Samir   +2 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

Pervasive Auto-Scaling Method for Improving the Quality of Resource Allocation in Cloud Platforms

open access: yesBig Data and Cognitive Computing
Cloud resource provider deployment at random locations increases operational costs regardless of the application demand intervals. To provide adaptable load balancing under varying application traffic intervals, the auto-scaling concept has been ...
Vimal Raja Rajasekar, G. Santhi
doaj   +1 more source

Stream Data Load Prediction for Resource Scaling Using Online Support Vector Regression

open access: yesAlgorithms, 2019
A distributed data stream processing system handles real-time, changeable and sudden streaming data load. Its elastic resource allocation has become a fundamental and challenging problem with a fixed strategy that will result in waste of resources or a ...
Zhigang Hu, Hui Kang, Meiguang Zheng
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

open access: yesMolecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller   +10 more
wiley   +1 more source

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