Results 41 to 50 of about 912,674 (282)
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
IEEE AccessCloud computing has revolutionized information technology (IT) infrastructure by providing benefits such as scalability, flexibility, and convenience. If the radio access networks of wireless systems are constructed on edge clouds, operators can obtain ...
Kiho Cho, Joongheon Kim, Soyi Jung
doaj +1 more source
Survey on auto elasticity techniques for microservices in cloud computing [PDF]
ITM Web of ConferencesMicroservices have become a popular way to build scalable and flexible cloud-native applications. However, the rapid growth of cloud services, edge computing platforms, and container-based deployments has created big challenges in managing computing ...
Dsouza Mary M., Purohit Nagamani N.
doaj +1 more source
An Auto-Scaling Approach for Microservices in Cloud Computing Environments
Journal of Grid Computing, 2023 Abstract Today, web applications are one of the most common applications providing service to users. Web application providers have moved their applications to cloud data centers. In this regard, microservices have become a famous architecture for building cloud-native applications.
Matineh ZargarAzad, Mehrdad Ashtiani
openaire +2 more sources
Job-queuing and Auto-scaling in Container-based Cloud Environments [PDF]
, 2018 Many applications process large quantities of data that takes significant time and requires big amount of compu- tational resources. Optimising the execution of such applications in a cloud computing environment by keeping costs at minimum but still ...
Kiss, T., Abu Oun, O.
core
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
A STACKED GENERALIZATION BASED META-CLASSIFIER FOR PREDICTION OF CLOUD WORKLOAD [PDF]
ICTACT Journal on Soft ComputingCloud computing has revolutionized the way software, platforms, and infrastructure can be acquired by making them available as on-demand services that can be accessed from anywhere via a web browser.
Sanjay T. Singh, Mahendra Tiwari
doaj +1 more source
Performance Modelling and Verification of Cloud-based Auto-Scaling Policies [PDF]
, 2017 Auto-scaling, a key property of cloud computing, allows application owners to acquire and release resources on demand. However, the shared environment, along with the exponentially large configuration space of available parameters, makes configuration of
Parker, David +5 more
core +1 more source
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
Physical ageing from generalised time-translation-invariance
Nuclear Physics BA generalised form of time-translation-invariance permits to re-derive the known generic phenomenology of ageing, which arises in classical many-body systems after a quench from an initially disordered system to a temperature T≤Tc, at or below the ...
Malte Henkel
doaj +1 more source