Results 51 to 60 of about 863,741 (284)
Cloud Resource Management With Turnaround Time Driven Auto-Scaling
IEEE Access, 2017 Cloud resource management research and techniques have received relevant attention in the last years. In particular, recently numerous studies have focused on determining the relationship between server-side system information and performance experience ...
Xiaolong Liu +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
A hybrid auto-scaling technique for clouds processing applications with service level agreements
Journal of Cloud Computing: Advances, Systems and Applications, 2017 This research focuses on the automatic provisioning of cloud resources by an intermediary enterprise. This enterprise provides a virtual private cloud for a single client enterprise by using resources from a public cloud.
Anshuman Biswas +3 more
doaj +1 more source
Auto-Scale Resource Provisioning In IaaS Clouds
The Computer Journal, 2020 AbstractUsers of cloud computing technology can lease resources instead of spending an excessive charge for their ownership. For service delivery in the infrastructure-as-a-service model of the cloud computing paradigm, virtual machines (VMs) are created by the hypervisor. This software is installed on a bare-metal server, called the host, and acted as
Zolfaghar Salmanian +2 more
openaire +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
TOSCA-Based and Federation-Aware Cloud Orchestration for Kubernetes Container Platform
Applied Sciences, 2019 Kubernetes, a container orchestration tool for automatically installing and managing Docker containers, has recently begun to support a federation function of multiple Docker container clusters.
Dongmin Kim +4 more
doaj +1 more source
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
Energy-aware Auto-scaling Algorithms for Cassandra Virtual Data Centers [PDF]
, 2017 Apache Cassandra is an highly scalable and available NoSql datastore, largely used by enterprises of each size and for application areas that range from entertainment to big data analytics.
Casalicchio, Emiliano, +8 more
core +1 more source
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source