Results 71 to 80 of about 617,211 (296)

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

TOSCA-Based and Federation-Aware Cloud Orchestration for Kubernetes Container Platform

Applied Sciences, 2019
Kubernetes, a container orchestration tool for automatically installing and managing Docker containers, has recently begun to support a federation function of multiple Docker container clusters.
Dongmin Kim, Hanif Muhammad, Eunsam Kim, Sumi Helal, Choonhwa Lee   +4 more
doaj   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Reinforcement-learning-based, application-agnostic, and explainable auto-scaling in the cloud utilizing high-level SLOs [PDF]

, 2023
Cloud computing is a widely adopted paradigm in the software industry. The ability to adapt the provisioned resources for an application based on the actual demand is called auto-scaling. Auto-scaling is crucial to keep costs within limits while ensuring
Mayerhofer, Robin
core   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Enabling modular design of an application-level auto-scaling and orchestration framework using tosca-based application description templates [PDF]

, 2019
This paper presents a novel approach to writing TOSCA templates for application reusability and portability in a modular auto-scaling and orchestration framework (MiCADO).
Kiss, T., Deslauriers, J., Pierantoni, G., Terstyanszky, G., Gesmier, G.   +4 more
core  

Proactive container auto-scaling for cloud native machine learning services [PDF]

, 2020
Understanding the resource usage behaviors of the ever-increasing machine learning workloads are critical to cloud providers offering Machine Learning (ML) services.
Youssef, Alaa, Alaa Youssef, Buchaca Prats, David, David Buchaca, Berral García, Josep Lluís, Wang, Chen, Josep LLuis Berral, Chen Wang   +7 more
core   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

A Dynamic Interval Auto-Scaling Optimization Method Based on Informer Time Series Prediction

IEEE Access
With the rapid development and application of container cloud computing-related technologies, more and more applications are being deployed to container cloud clusters.
Yu Ding, Chenhao Li, Zhengong Cai, Xinghao Wang, Bowei Yang   +4 more
doaj   +1 more source

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

FEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta, Nidhi Yadav, Subhasmita Das, R. Rajendra Kumar Reddy, Nupur Sharma, Amol Ratnakar Suryawanshi, Jaswinder Singh Maras, Ranjan Kumar Nanda   +7 more
wiley   +1 more source