Results 71 to 80 of about 8,251,079 (331)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

open access: yesMolecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller   +10 more
wiley   +1 more source

Reinforcement-learning-based, application-agnostic, and explainable auto-scaling in the cloud utilizing high-level SLOs [PDF]

open access: yes, 2023
Cloud computing is a widely adopted paradigm in the software industry. The ability to adapt the provisioned resources for an application based on the actual demand is called auto-scaling. Auto-scaling is crucial to keep costs within limits while ensuring
Mayerhofer, Robin
core   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

open access: yesFEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj   +3 more
wiley   +1 more source

Competitive strategies of late followers in auto industry: Case study Hyundai-Kia [PDF]

open access: yesIndustrija, 2017
This paper analyzes competitive strategy of late followers in auto industry in the case of Hyundai Kia Auto Group (HKAG). The global economic crisis has had a strong impact on the leaders in auto industry.
Rakita Branko   +2 more
doaj   +1 more source

Enabling modular design of an application-level auto-scaling and orchestration framework using tosca-based application description templates [PDF]

open access: yes, 2019
This paper presents a novel approach to writing TOSCA templates for application reusability and portability in a modular auto-scaling and orchestration framework (MiCADO).
Kiss, T.   +4 more
core  

Dynamic Multi-level Auto-scaling Rules for Containerized Applications

open access: yes, 2018
Container-based cloud applications require sophisticated auto-scaling methods in order to operate under different workload conditions. The choice of an auto-scaling method may significantly affect important service quality parameters, such as response ...
Vlado Stankovski, Salman Taherizadeh
core   +1 more source

Proactive container auto-scaling for cloud native machine learning services [PDF]

open access: yes, 2020
Understanding the resource usage behaviors of the ever-increasing machine learning workloads are critical to cloud providers offering Machine Learning (ML) services.
Youssef, Alaa   +7 more
core   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

Auto Clicker CS Onlc

open access: yes, 2023
  Auto Clicker Download and Installation Instruction As an AI language model, I cannot provide instructions for illegal or unethical activities such as using auto clicker software to cheat in online games or bypass website security measures.
Auto Clicker CS Onlc (16631946)
core   +2 more sources

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