Results 111 to 120 of about 159,852 (315)

Differences in the humoral autoreactivity to zinc transporter 8 between childhood- and adult-onset type 1 diabetes in Japanese patients. [PDF]

, 2011
The aim of this study was to evaluate the humoral autoreactivity to zinc transporter 8 (ZnT8) depending on the clinical phenotype of type 1 diabetes (T1D).
Eguchi, Katsumi, Kan Nakamura, Yamasaki, Hironori, Miura, Junnosuke, Tsuyoshi Satoh, Nobuo Matsuura, Kobayashi, Masakazu, Uchigata, Yasuko, Satoh, Tsuyoshi, Kuwahara, Hironaga, Matsuura, Nobuo, Katsumi Eguchi, Kuriya, Genpei, Abiru, Norio, Norio Abiru, Kawasaki, Eiji, Masakazu Kobayashi, Genpei Kuriya, Hironaga Kuwahara, Hironori Yamasaki, Eiji Kawasaki, Junnosuke Miura, Nakamura, Kan, Yasuko Uchigata   +23 more
core   +1 more source

Macrophage Extracellular Traps in Immunity and Cancer

Advanced Science, EarlyView.
As a macrophage‐mediated innate defense mechanism, the dysregulated release of METs drives chronic inflammation and influences tumor progression. Furthermore, METs exhibit a functional duality within the tumor microenvironment, capable of both promoting and suppressing tumor development.
Junyao Li, Eugenie Nepovimova, Adam Grundel, Lukas Peter, Qinghua Wu, Kamil Kuca   +5 more
wiley   +1 more source

A novel platform for isotype-specific testing of autoantibodies.

PLoS ONE, 2019
The objective of this study was to test if a novel platform could be used for isotype-specific autoantibody testing in humans. Further, we evaluated if testing with this novel platform enables earlier detection of insulin autoantibodies in individuals ...
Kaylene L Carter, Anckia Treurnicht, Kara L Davis, Rajiv B Kumar, Brian J Feldman   +4 more
doaj   +1 more source

Targeting METTL3 Attenuates Thyroid Inflammatory Injury by Restoring Th17/Treg Balance through a YTHDC2‐m6A‐Dependent KDR/VEGFA Loop

Advanced Science, EarlyView.
METTL3‐mediated m6A modification stabilizes KDR/Kdr mRNA through YTHDC2, amplifying the VEGFA‐KDR feedback loop and disturbing Th17/Treg balance. This pathway promotes persistent inflammation and tissue damage in patients with AIT, and inhibiting the METTL3‐KDR axis effectively disrupts this circuit, alleviating thyroid tissue injury and disease ...
Qingyi Hu, Huan Liu, Anwen Ren, Zimei Tang, Jie Tan, Wen Yang, Jie Ming, Tao Huang   +7 more
wiley   +1 more source

Ghrelin-reactive autoantibodies are elevated in children with Prader-Willi Syndrome

, 2016
Prader-Willi Syndrome (PWS) is a complex genetic disorder characterized by developmental and growth abnormalities, insatiable appetite, and excessive eating (hyperphagia). The underlying cause of hyperphagia in PWS is currently unknown, however, elevated
Seim, Inge, Harris, Mark, Jeffery, Penny, Nyunt, Ohn, Crisp, Gabrielle, Chopin, Lisa   +5 more
core   +1 more source

Divergent Roles of mGlu2 and mGlu3 Receptors in Amyloid‐β Production and Cognitive Dysfunctions in Alzheimer's Disease

Advanced Science, EarlyView.
This study explores the opposing effects of the mGluR2 and mGluR3 receptors on amyloid precursor protein processing. mGluR2 promotes amyloidogenic cleavage, while mGluR3 favors non‐amyloidogenic pathways. Using a brain‐penetrant nanobody as a mGluR2 positive allosteric modulator, the study uncovers how its chronic activation aggravates amyloid‐β burden
Pierre‐André Lafon, Mireille Elodie Tsitokana, Ugo Guy Alenda, Yen‐Ling Lian, Clémentine Eva Philibert, Mathieu Oosterlaken, Marta Cimadevila, Gaëlle Dudon, Jessica Monnic, Salomé Roux, Julie Bessié, Séverine Diem, Franck Vandermoere, Laurent Prézeau, Patrick Chames, Julie Kniazeff, Sylvie Claeysen, Anaïs Menny, Jean‐Philippe Pin, Véronique Perrier, Jianfeng Liu, Philippe Rondard   +21 more
wiley   +1 more source

Differentiating pathogenic from bystander autoantibodies in immune thrombocytopenia using intact glycoprotein-deficient megakaryocytes

Haematologica
Autoantibodies targeting platelet surface glycoproteins (GP) are the primary cause of immune thrombocytopenia (ITP), however testing for these autoantibodies is not routinely employed mainly because current diagnostic tests lack sufficient sensitivity ...
Nanyan Zhang, Günalp Uzun, Tamam Bakchoul, Brian R. Curtis, Peter J. Newman   +4 more
doaj   +1 more source

Laser‐Induced Periodic Phase‐Transition of 2D‐MoTe2 Nanograting Template for Frequency‐Shift Digital‐SERS Immunoassay of Autoimmune Disease

Advanced Science, EarlyView.
A protocol of fs‐laser‐induced periodic phase‐transition of 2D‐MoTe2 template, inducing AuNPs@1T’‐MoTe2 nanograting, is developed. The labeled AuNPs@1T’‐MoTe2 substrate conjugated with specialized immunoglobulin G demonstrates an unexpectedly high discrimination accuracy close to unity for serological diagnosis of rheumatoid arthritis by frequency ...
Yao Yao, Lulu Cao, Xiaolin Sun, Qiang Wang, Zhiyang Xu, Tianrui Zhai, Yan Zhao, Yijian Jiang, Zhanguo Li, Yinzhou Yan   +9 more
wiley   +1 more source

Environmental factors that contribute to autoimmunity

, 2005
This is the first book to address all aspects of the biology of autoantibodies in a single volume, including a discussion of immunology, experimental models, clinical aspects, and the use of autoantibodies as probes in molecular and cellular biology. The
Hultman, Per,
core   +1 more source

The RNA‐Binding Protein PARN Remodeled 3′ UTR Structure Defines Poly(A)‐Loading Sites to Mediate Immunoglobulin Homeostasis

Advanced Science, EarlyView.
ABSTRACT Class Switch Recombination (CSR) is essential for generating high‐affinity antibody isotypes from IgM during adaptive humoral responses. Despite well‐established roles for various transcription factors, whether CSR is subject to dedicated post‐transcriptional control represents a significant gap in knowledge.
Siyuan Sun, Chen Yang, Xiaoyu Wang, Naijing Hu, Shengyao Zhang, Xinchun Li, Yu Chen, Jianan Zhai, Xiangfeng Tang, Wei Lu, Chenxu Lu, Changchang Cao, Weiru Yu, Wenhao Wu, Xiaonan Nie, Fengchao Wang, Bing Fang, Fazheng Ren, Yixuan Li, Juan Chen   +19 more
wiley   +1 more source