Results 281 to 290 of about 139,183 (310)
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Current Diabetes Reports, 2016
Islet autoantibodies are the main markers of pancreatic autoimmunity in type 1 diabetes (T1D). Islet autoantibodies recognize insulin (IAA), glutamic acid decarboxylase (GADA), protein phosphatase-like IA-2 (IA-2A), and ZnT8 (ZnT8A), all antigens that are found on secretory granules within pancreatic beta cells.
Daniela Liberati, Vito Lampasona
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Islet autoantibodies are the main markers of pancreatic autoimmunity in type 1 diabetes (T1D). Islet autoantibodies recognize insulin (IAA), glutamic acid decarboxylase (GADA), protein phosphatase-like IA-2 (IA-2A), and ZnT8 (ZnT8A), all antigens that are found on secretory granules within pancreatic beta cells.
Daniela Liberati, Vito Lampasona
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2013
Introduction Techniques: overview Particle agglutination assays Immunoprecipitation assays Indirect immunofluorescence Direct immunofluorescence
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Introduction Techniques: overview Particle agglutination assays Immunoprecipitation assays Indirect immunofluorescence Direct immunofluorescence
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Autoantibodies and their significance
Current Opinion in Rheumatology, 1993In systemic lupus erythematosus, autoantibodies have structural features that indicate in vivo selection by a T cell-dependent, antigen-driven process. The B-cell component of these responses resembles a conventional antibody response, whereas the T-cell component may involve diverse stimulatory mechanisms and levels of regulatory control ...
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Immunology Letters, 1987
Autoimmune diseases are characterized by the appearance of autoantibodies (autoAb) which may participate in their pathogenesis, but autoAb have also been found in normals with a variety of other conditions. The production of hybridomas from lymphocytes of unimmunized normal mice and healthy humans and analysis of the monoclonal autoAb (m-autoAb ...
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Autoimmune diseases are characterized by the appearance of autoantibodies (autoAb) which may participate in their pathogenesis, but autoAb have also been found in normals with a variety of other conditions. The production of hybridomas from lymphocytes of unimmunized normal mice and healthy humans and analysis of the monoclonal autoAb (m-autoAb ...
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The Journal of Dermatology, 1993
AbstractAutoantibodies directed against nuclear, nucleolar, and a number of cytoplasmic components are described in the sera of scleroderma patients. Early studies of autoantibodies that relied on cryopreserved sections of rodent organ substrates showed that approximately 50% of scleroderma patients had anti‐nuclear antibodies (ANA).
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AbstractAutoantibodies directed against nuclear, nucleolar, and a number of cytoplasmic components are described in the sera of scleroderma patients. Early studies of autoantibodies that relied on cryopreserved sections of rodent organ substrates showed that approximately 50% of scleroderma patients had anti‐nuclear antibodies (ANA).
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2019
Research into antibody-mediated disease, in response to immune dysfunction or to tumour development, has rapidly expanded in recent years. Antibodies binding to neuroreceptors can cause psychiatric features, including psychosis, in a minority of patients as well as neurological features.
David Cotter +4 more
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Research into antibody-mediated disease, in response to immune dysfunction or to tumour development, has rapidly expanded in recent years. Antibodies binding to neuroreceptors can cause psychiatric features, including psychosis, in a minority of patients as well as neurological features.
David Cotter +4 more
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Current Opinion in Immunology, 1995
Autoantibodies of the IgM, IgG and IgA classes, reactive with a variety of serum proteins, cell surface structures and intracellular structures, are 'naturally' found in all normal individuals. Present in human cord blood and in 'antigen-free' mice, their variable-region repertoire is selected by antigenic structures in the body and remains conserved ...
A, Coutinho +2 more
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Autoantibodies of the IgM, IgG and IgA classes, reactive with a variety of serum proteins, cell surface structures and intracellular structures, are 'naturally' found in all normal individuals. Present in human cord blood and in 'antigen-free' mice, their variable-region repertoire is selected by antigenic structures in the body and remains conserved ...
A, Coutinho +2 more
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1996
In l961, Beck reported that the sera of patients with rheumatic diseases contained antibodies to nucleolar structures, and further studies in the 1970s showed that such anti-nucleolar antibodies (ANoA) were more frequent in patients with scleroderma. A nucleolar immunofluorescence pattern described as “clumpy” was shown to be due to antibodies to a 34 ...
Per Hultman, K. Michael Pollard
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In l961, Beck reported that the sera of patients with rheumatic diseases contained antibodies to nucleolar structures, and further studies in the 1970s showed that such anti-nucleolar antibodies (ANoA) were more frequent in patients with scleroderma. A nucleolar immunofluorescence pattern described as “clumpy” was shown to be due to antibodies to a 34 ...
Per Hultman, K. Michael Pollard
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Current Opinion in Immunology, 1988
It is generally accepted that systemic autoimmune diseases such as systemic lupus erythematosus (EXE), mixed connective tissue disease, SjOgrens syndrome and polymyositis, are associated with the production of an extensive array of autoantibody specificities [ 1,2].
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It is generally accepted that systemic autoimmune diseases such as systemic lupus erythematosus (EXE), mixed connective tissue disease, SjOgrens syndrome and polymyositis, are associated with the production of an extensive array of autoantibody specificities [ 1,2].
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1964
Publisher Summary The chapter discusses the autoantibodies which have been discovered in autoimmune diseases and a comparison of the reactivity against the Gm groups on human y-globulin of rheumatoid factors on the one hand with the “serum normal agglutinators” on the other.
H.G. Kunkel, E.M. Tan
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Publisher Summary The chapter discusses the autoantibodies which have been discovered in autoimmune diseases and a comparison of the reactivity against the Gm groups on human y-globulin of rheumatoid factors on the one hand with the “serum normal agglutinators” on the other.
H.G. Kunkel, E.M. Tan
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