Results 71 to 80 of about 139,183 (310)
Functional activity of peptide ion channels in tethered bilayer lipid membranes: Review
Electrochemical Science Advances, Volume 2, Issue 6, December 2022., 2022 Abstract Ion transport across biomembranes plays a major role in living cells. This fundamental function is normally carried out by molecules with both a hydrophobic and a hydrophilic side (amphiphilic molecules), which aggregate within the membrane forming a hydrophilic pore (the ion channel) permitting the selective translocation of permeant ions ...
Rolando Guidelli, Lucia Becucci
wiley +1 more source
Extrahepatic Manifestations and Autoantibodies in Patients with Hepatitis C Virus Infection
Clinical and Developmental Immunology, 2012 Patients with chronic hepatitis C virus (HCV) infection frequently have many extrahepatic manifestations, as persistent HCV infection often triggers lymphoproliferative disorders and metabolic abnormalities.
Takashi Himoto, Tsutomu Masaki
doaj +1 more source
Current Opinion in Rheumatology, 2012 To review recent advances in our understanding of autoantibodies associated with dermatomyositis and the autoimmune necrotizing myopathies.Autoantibodies preferentially associated with dermatomyositis include those recognizing Mi-2, MDA5, TIF1γ, and NXP-2. Each of these is associated with a distinct clinical phenotype.
Livia, Casciola-Rosen, Andrew L, Mammen
openaire +2 more sources
Dynamic Pathophysiological Insight into the Brain by NIR‐II Imaging
Advanced Science, EarlyView.The functional integration of benefits from small semiconducting dyes and biocompatible serum proteins ushered in a new frontier of deep wide‐field in vivo imaging technique, affording valuable pathophysiological insight into the functioning of neurovascular unit in space and time.
Si Chen +9 more
wiley +1 more source
Advanced Science, EarlyView.A quantitative CTC RNA assay is developed by incorporating multi‐antibody‐based CTC isolation and specific mRNA quantification using RT‐ddPCR. The NSCLC CTC ScoreD demonstrates high accuracy for early‐stage NSCLC detection, significantly outperforming serum CEA. NSCLC CTC ScoreM exhibits a more accurate early‐warning of responses to different therapies
Xiaoyu Wang +14 more
wiley +1 more source
The Origins, Specificity, and Potential Biological Relevance of Human Anti-IgG Hinge Autoantibodies
The Scientific World Journal, 2011 Human anti-IgG hinge (HAH) autoantibodies constitute a class of immunoglobulins that recognize cryptic epitopes in the hinge region of antibodies exposed after proteolytic cleavage, but do not bind to the intact IgG counterpart.
Randall J. Brezski +2 more
doaj +1 more source
Advanced Science, EarlyView.This study develops lipid nanoparticle‐encapsulated mRNA‐encoding antibodies (mRNab‐LNPs) targeting CD19, demonstrating robust anti‐CD19 antibody production in vivo. Intramuscular injection of mRNab‐LNPs reduces CD19+ B and plasma cells in lupus and rheumatoid arthritis mice, significantly alleviating histopathological changes and tissue injuries of ...
Chipeng Guo +10 more
wiley +1 more source
A novel platform for isotype-specific testing of autoantibodies.
PLoS ONE, 2019 The objective of this study was to test if a novel platform could be used for isotype-specific autoantibody testing in humans. Further, we evaluated if testing with this novel platform enables earlier detection of insulin autoantibodies in individuals ...
Kaylene L Carter +4 more
doaj +1 more source
A multi-etiology model of systemic degeneration in schizophrenia [PDF]
arXiv, 2008 We discuss the possibility of multiple underlying etiologies of the condition currently labeled as schizophrenia. We support this hypothesis with a theoretical model of the prefrontal-limbic system. We show how the dynamical behavior of this model depends on an entire set of physiological parameters, representing synaptic strengths, vulnerability to ...
arxiv
Annals of Gastroenterological Surgery, EarlyView.The six autoantibodies (Sui1, p62, RalA, p53, NY‐ESO‐1 and c‐myc) positive group had poor prognosis compared to autoantibody negative group. A panel of autoantibodies against a tumor associated antigen in esophageal cancer patients had an additive effect with SCC‐Ag to detect esophageal SCC even in early stage.
Fumiaki Shiratori +16 more
wiley +1 more source