Results 141 to 150 of about 228,187 (396)

Human Traumatic Brain Injury Induces Autoantibody Response against Glial Fibrillary Acidic Protein and Its Breakdown Products

PLoS ONE, 2014
The role of systemic autoimmunity in human traumatic brain injury (TBI) and other forms of brain injuries is recognized but not well understood. In this study, a systematic investigation was performed to identify serum autoantibody responses to brain ...
Zhiqun Zhang, J. S. Zoltewicz, S. Mondello, Kimberly J. Newsom, Zhihui Yang, Boxuan Yang, F. Kobeissy, Joy D. Guingab, Olena Y. Glushakova, S. Robicsek, S. Heaton, A. Buki, J. Hannay, M. Gold, R. Rubenstein, Xi-chun May Lu, Jitendra R. Dave, Kara E. Schmid, F. Tortella, Claudia S. Robertson, Kevin K W Wang   +20 more
semanticscholar   +1 more source

Molecular mechanisms of autoimmunity triggered by microbial infection [PDF]

, 2005
Autoimmunity can be triggered by microbial infection. In this context, the discovery of Toll-like receptors (TLRs) provides new insights and research perspectives.
Anders, Hans-Joachim, Patole, Prashant S, Pawar, Rahul D, Zecher, Daniel   +3 more
core   +2 more sources

Ageing and Autoantibodies

Autoimmunity, 1988
Immune responsiveness decreases with age, while the production of autoantibodies increases, indicating that these are end results of perturbations in the regulatory mechanisms of the immune system. The effects of ageing on the immune system are reviewed.
Yaron Tomer, Yehuda Shoenfeld
openaire   +3 more sources

Activin A‐activated ALK4 induces pathogenic Th17 involved endothelial–mesenchymal transition in systemic lupus erythematosus‐associated pulmonary arterial hypertension

Arthritis &Rheumatology, Accepted Article.
Objective Autoimmune diseases, such as systemic lupus erythematosus (SLE), are associated with pulmonary arterial hypertension (PAH), a condition that can lead to heart failure. However, whether T cells also contribute to the occurrence of PAH in SLE, has not been clarified.
Shuliang Jing, Junyan Qian, Hongjie Ying, Pei Mao, Mingxin Yao, Zhihong Wu, Harm J Bogaard, Lie Wang, Mengtao Li, Jun Yang   +9 more
wiley   +1 more source

Autoantibodies Against the Node of Ranvier in Seropositive Chronic Inflammatory Demyelinating Polyneuropathy: Diagnostic, Pathogenic, and Therapeutic Relevance

Frontiers in Immunology, 2018
Discovery of disease-associated autoantibodies has transformed the clinical management of a variety of neurological disorders. Detection of autoantibodies aids diagnosis and allows patient stratification resulting in treatment optimization.
Atay Vural, Atay Vural, Kathrin Doppler, Edgar Meinl   +3 more
doaj   +1 more source

Human lupus autoantibody-DNA complexes activate DCs through cooperation of CD32 and TLR9.

Journal of Clinical Investigation, 2005
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by pathogenic autoantibodies against nucleoproteins and DNA. Here we show that DNA-containing immune complexes (ICs) within lupus serum (SLE-ICs), but not protein-containing ICs ...
T. Means, E. Latz, F. Hayashi, M. Murali, D. Golenbock, A. Luster   +5 more
semanticscholar   +1 more source

FGL‐1 Modulates Inter‐Organ Communication by Controlling T Cell Homeostasis during the Onset of Sjögren's Disease

Arthritis &Rheumatology, Accepted Article.
Objective Autoimmunity occurs due to the tactics between pathogenic and regulatory factors in systemic organs. Although inter‐organ communication has been demonstrated in various diseases, the effects of the crosstalk between the immune system and other organs on autoimmune disease is unknown.
Kunihiro Otsuka, Aya Ushio, Ruka Nagao, Shigefumi Matsuzawa, Rieko Arakaki, Kazuki Fukuta, Yasuhiro Mouri, Takaaki Tsunematsu, Naozumi Ishimaru   +8 more
wiley   +1 more source

CAQ Corner: Immune‐mediated complications

, 2022
Liver Transplantation, EarlyView.
Mary Thomson, John R. Lake
wiley   +1 more source

Immunopathology of autoantibody-associated encephalitides: clues for pathogenesis.

Brain : a journal of neurology, 2012
Classical paraneoplastic encephalitis syndromes with 'onconeural' antibodies directed to intracellular antigens, and the recently described paraneoplastic or non-paraneoplastic encephalitides and antibodies against both neural surface antigens (voltage ...
C. Bien, A. Vincent, M. Barnett, A. Becker, I. Blümcke, F. Graus, K. Jellinger, D. Reuss, T. Ribalta, J. Schlegel, I. Sutton, H. Lassmann, J. Bauer   +12 more
semanticscholar   +1 more source

Isolation and characterization of a light chain variable region gene for human rheumatoid factors. [PDF]

, 1987
Previously, we isolated a Vk gene (Humkv325) from a human placenta that encodes RF light chains bearing the PSL2 and PSL3 CRI markers. Here we report the isolation and characterization of a second human Vk gene (Humkv328) that can be used for RF ...
Carson, DA, Chen, PP, Jirik, FR, Kipps, TJ, Robbins, DL   +4 more
core