Results 61 to 70 of about 3,278 (226)

The Asymmetric Self‐Replicative Alkylation of N‐Arylaldimines Using Organolithium Reagents

Chemistry – A European Journal, EarlyView.
Here, we report a new asymmetric autoinductive reaction; the addition of nBuLi to N‐arylaldimines to form chiral lithium amides. The reaction proceeds with full conversion and complete transfer of chirality, representing the first example of an asymmetric autoinductive reaction with organolithium reagents.
Anka Hagelschuer, Paco Visser, Ben L. Feringa   +2 more
wiley   +1 more source

Synthesis and Biological Evaluation of Well‐Defined M6P(n)‐Modified Glycopeptides for Targeted Protein Degradation

Chemistry – A European Journal, EarlyView.
A synthetic methodology has been developed to prepare multifunctional M6P and M6Pn ligands of different valency. The glycopeptides were conjugated to cetuximab and then examined to mediate cellular uptake of fluorescently labeled EGFRvIII. Only cetuximab modified by glycopeptides having 3 or 6 M6P or M6Pn residues demonstrated greater uptake.
Patrycja Lenartowicz, Jan‐Willem H. Langenbach, Nataliia Voloshyna, David Aidukas, Arwin J. Brouwer, John A. W. Kruijtzer, Geert‐Jan Boons   +6 more
wiley   +1 more source

Enhanced Electron‐Capturing by Single‐Atomic Iron on Pyridinic N‐Deficient Carbon Drives Self‐Oxidative Degradation of Pollutants

ENERGY &ENVIRONMENTAL MATERIALS, EarlyView.
Pyrolysis of FeOx/g‐C3N4 and ZIF‐8 is performed to introduce Fe single atom and pyridinic nitrogen vacancies onto N‐doped carbon. This modification enables the materials to efficiently extract electrons from ciprofloxacin (CIP) and activate dissolved oxygen. 100% of CIP was degraded within 1 min without adding any oxidant.
Jianyang Gao, Ruonan Wang, Haifeng Lin, Jun Xing, Jixiang Xu, Lei Wang   +5 more
wiley   +1 more source

Catalytic Antioxidant Activity of Acyclic and Macrocyclic Selenides: Insights Into Structure–Activity Relationships and Mechanisms From Kinetic and Computational Studies

European Journal of Organic Chemistry, EarlyView.
Structure–activity relationships of antioxidant activities of selenides were established by experimental and computational methods. Several structures displayed strong catalytic activity in an NMR‐based assay. Diverse selenides were shown to act as potent catalytic antioxidants.
Adrian I. Doig, Wen Zhou, Thomas G. Back
wiley   +1 more source

A recursive microfluidic platform to explore the emergence of chemical evolution

Beilstein Journal of Organic Chemistry, 2017
We propose that a chemically agnostic approach to explore the origin of life, using an automated recursive platform based on droplet microfluidics, could be used to induce artificial chemical evolution by iterations of growth, speciation, selection, and ...
David Doran, Marc Rodriguez-Garcia, Rebecca Turk-MacLeod, Geoffrey J. T. Cooper, Leroy Cronin   +4 more
doaj   +1 more source

Plasmepsins as Antimalarial Drug Targets—Then, Now, and the Future

Medicinal Research Reviews, EarlyView.
ABSTRACT Malaria is a devastating disease caused by Plasmodium parasites. Plasmodium parasites express ten cathepsin D‐like aspartyl proteases, called plasmepsins (PMs). These PMs have diverse roles fulfill diverse functions throughout the parasite's lifecycle, though several exhibit functional redundancies. Among them, PMV, PMIV, and PMX are essential
Brad E. Sleebs
wiley   +1 more source

Machine Learning Assisted Prediction of Degradation Behavior of Poly(Lactic‐Co‐Glycolic Acid)

Materials Genome Engineering Advances, EarlyView.
Using a gradient boosting‐based machine learning model trained on 484 data points, this study predicts the degradation behavior of poly(lactic‐co‐glycolic acid) (PLGA) implants. Degradation time, molecular weight, and lactide/glycolide ratio were identified as key governing factors, enabling accurate prediction while reducing reliance on extensive ...
Shuai Wang, Long Chen, Kepeng Yang, Bowen Cheng, Yingpeng Wan, Bingyan Wang, Tao Sun, Xiangping Hao, Jingzhi Yang, Haijun Zhang, Lei Wang, Lu‐Ning Wang   +11 more
wiley   +1 more source

Navigating the Chemical Space of HCN Polymerization and Hydrolysis: Guiding Graph Grammars by Mass Spectrometry Data

Entropy, 2013
Polymers of hydrogen cyanide and their hydrolysis products constitute a plausible, but still poorly understood proposal for early prebiotic chemistry on Earth.
Peter F. Stadler, Daniel Merkle, Jakob L. Andersen, Tommy Andersen, Christoph Flamm, Martin M. Hanczyc   +5 more
doaj   +1 more source

Accelerated Degradation of PLA‐Based Composites in Harsh Alkaline Environment

Polymer Composites, EarlyView.
Evolution of surface properties and features of RP sample treated in harsh conditions: FTIR and wetting analysis. ABSTRACT The performance of poly(lactic acid) (PLA) bioplastics under harsh service conditions must be understood to enable their use in multi‐use products.
Cristina Moliner, Alberto Lagazzo, Juan Felipe Basbus, Roberto Raiteri, Elisabetta Finocchio, Elisabetta Arato   +5 more
wiley   +1 more source

Prebiotic Competition between Information Variants, With Low Error Catastrophe Risks

Entropy, 2015
During competition for resources in primitive networks increased fitness of an information variant does not necessarily equate with successful elimination of its competitors.
Radu Popa, Vily Marius Cimpoiasu
doaj   +1 more source