Results 31 to 40 of about 860,119 (367)

Synthesis, telomerase inhibitory and anticancer activity of new 2-phenyl-4H-chromone derivatives containing 1,3,4-oxadiazole moiety

Journal of Enzyme Inhibition and Medicinal Chemistry, 2021
Based on previous studies, 66 2-phenyl-4H-chromone derivatives containing amide and 1,3,4-oxadiazole moieties were prepared as potential telomerase inhibitors.
Xu Han, Yun Long Yu, Duo Ma, Zhao Yan Zhang, Xin Hua Liu   +4 more
doaj   +1 more source

Sensory Neuronopathy And Autoimmune Diseases.

, 2015
Sensory neuronopathies (SNs) are a specific subgroup of peripheral nervous system diseases characterized by primary degeneration of dorsal root ganglia and their projections.
Nucci, Anamarli, Martinez, Alberto R M, França, Marcondes C, Nunes, Marcelo B   +3 more
core   +1 more source

Dysbiosis and probiotic applications in autoimmune diseases

, 2022
Several evidence in animal models and humans pointed to the involvement of oral and intestinal dysbiosis in the development of autoimmune diseases. Dysbiosis is associated with decreased bacterial function and diversity, as well as decreased beneficial ...
Salis, Larissa Vedovato Vilela de [UNESP], Guilherme Siqueira Pardo Rodrigues, Martins, Luísa Sales [UNESP], Larissa Vedovato Vilela de Salis, Gislane Lelis Vilela de Oliveira, Luísa Sales Martins, Rodrigues, Guilherme Siqueira Pardo [UNESP], Oliveira, Gislane Lelis Vilela de [UNESP]   +7 more
core   +1 more source

Aminotransferases During Treatment Predict Long-Term Survival in Patients With Autoimmune Hepatitis Type 1:A Landmark Analysis [PDF]

, 2022
Background & Aims: Biochemical remission, important treatment goal in autoimmune hepatitis (AIH), has been associated with better long-term survival.
Sermon, F., van den Berg, Aad, Verhelst, X., Sermon, Filip, Biewenga, M., Drenth, J.P.H., Colle, I., van der Meer, Adriaan, Schouten, J., Dutch Autoimmune Hepatitis Study G, van Hoek, Bart, Hoek, B. van, Meer, A. van der, Meer, Adriaan van der, Steenkiste, C. Van, Baven-Pronk, Martine, Putter, Hein, Putter, H., Vlierberghe, H. van, Berg, A. van den, Colle, Isabelle, Schouten, Jeoffrey, van Vlierberghe, Hans, Van Steenkiste, Christophe, Biewenga, Maaike, Dutch Autoimmune Hepatitis Study Group, Verhelst, Xavier, Baven-Pronk, M.   +27 more
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Integrative Single-Cell RNA-Seq and ATAC-Seq Analysis of Peripheral Mononuclear Cells in Patients With Ankylosing Spondylitis

Frontiers in Immunology, 2021
ObjectiveGenetic studies on ankylosing spondylitis (AS) have identified more than 100 pathogenic genes. Building a bridge between these genes and biologically targeted therapies is the current research hotspot.MethodsWe integrated single-cell assaying ...
Huixuan Xu, Haiyan Yu, Lixiong Liu, Hongwei Wu, Cantong Zhang, Wanxia Cai, Xiaoping Hong, Dongzhou Liu, Donge Tang, Yong Dai, Yong Dai   +10 more
doaj   +1 more source

The CYP2D6 animal model: how to induce autoimmune hepatitis in mice

, 2012
Autoimmune hepatitis is a rare but life threatening autoimmune disease of the liver of unknown etiology1,2. In the past many attempts have been made to generate an animal model that reflects the characteristics of the human disease 3-5.
Christen, Urs, Hintermann, Edith, Ehser, Janine   +2 more
core   +1 more source

A Comparative Study of Demographic and Clinical Criteria Between Male and Female Patients With Pemphigus Referred to a Referral Hospital in Iran

Dermatology Research and Practice
Conclusion: The study highlights significant gender differences in the presentation and severity of pemphigus, underscoring the importance of gender-specific approaches in the diagnosis and management of this condition.
Zeinab Aryanian, Kamran Balighi, Nafiseh Esmaeli, Maryam Daneshpazhooh, Nasim Mazloomi Tootoonchi, Zahra Razavi, Fereshteh Beigmohammadi, Umamah Gul, Azadeh Khayyat, Parvaneh Hatami   +9 more
doaj   +1 more source

The great pretender : Autoimmune Pancreatitis [PDF]

, 2014
Autoimmune pancreatitis is a benign disorder which frequently presents with symptoms and imaging suggestive of pancreatic malignancy. Up to 21% of pancreatoduodenectomies performed for suspected pancreatic cancer are found to have benign disease ...
Azzopardi, Neville
core  

Fas/Apo1 mutations and autoimmune lymphoproliferative syndrome in a patient with type 2 autoimmune hepatitis.

, 1997
Inherited mutations of the Fas/Apo1/CD95 gene, a cell-surface receptor involved in cell death signaling and in the control of self-reactivity, characterize the recently identified autoimmune lymphoproliferative syndromes. A patient with type 2 autoimmune
NISINI R, VAJRO P, ALMERIGHI C, IANNI A, COSTANZO A, NATOLI G, IORIO, RAFFAELE, LEVRERO M. FASAPO MUTATIONS AND AUTOIMMUNE LYMPHOPROLIFERATIVE SYNDROME IN A. PATIENT WITH TYPE AUTOIMMUNE H.E.P.A.T.I.T.I.S. GASTROENTEROLOGY, VEGNENTE A, BALSANO C, ACCAPEZZATO D, PENSATI L   +11 more
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Breaking tolerance to the natural human liver autoantigen cytochrome P450 2D6 by virus infection [PDF]

, 2008
Autoimmune liver diseases, such as autoimmune hepatitis (AIH) and primary biliary cirrhosis, often have severe consequences for the patient. Because of a lack of appropriate animal models, not much is known about their potential viral etiology. Infection
Hintereder, Gudrun, Gudrun Hintereder, Michael P. Manns, Christen, Urs, Herrath, Matthias G. von, Holdener, Martin, Monika Bayer, Johnson, Eric F., Urs Christen, Rodrigo, Evelyn, Frank J. Gonzalez, Pfeilschifter, Josef (Prof. Dr.), Eric F. Johnson, Evelyn Rodrigo, Gonzalez, Frank J., Martin Holdener, Edith Hintermann, Hintermann, Edith, Matthias von G. Herrath, Josef Pfeilschifter, Rhode, Antje, Bayer, Monika, Manns, Michael P., Antje Rhode   +23 more
core   +1 more source