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Seronegative Autoimmune Diseases

Annals of the New York Academy of Sciences, 2009
A close relationship exists between autoimmunity and autoantibodies; despite this, some patients are persistently negative for disease‐specific autoantibodies. These conditions have been defined as seronegative autoimmune diseases. Although the prevalence of seronegative autoimmune diseases is low, they may represent a practical problem because they ...
ALESSANDRI, cristiano   +5 more
openaire   +4 more sources

Autoimmune Liver Disease

The Indian Journal of Pediatrics, 2002
Autoimmune liver disorders are inflammatory liver diseases characterised histologically by a dense mononuclear cell infiltrate in the portal tract and serologically by the presence of non-organ and liver specific autoantibodies and increased levels of immunoglobulin G (IgG), in the absence of a known etiology.
Mieli-Vergani, G, Vergani, D
openaire   +3 more sources

Autoimmune pre-disease

Autoimmunity Reviews, 2023
Approximately 5% of the world-wide population is affected by autoimmune diseases. Overall, autoimmune diseases are still difficult to treat, impose a high burden on patients, and have a significant economic impact. Like other complex diseases, e.g., cancer, autoimmune diseases develop over several years.
Katja, Bieber   +29 more
openaire   +2 more sources

Autoimmune thyroid disease

Current Opinion in Rheumatology, 2012
Autoimmune thyroid disorders (AITDs) are the most common organ-specific autoimmune disorders. The genetics as well as clinical and laboratory manifestations of AITDs are reviewed.We discuss the association between specific rheumatologic disorders and AITDs and manifestations of AITDs that mimic rheumatologic disorders.
Nikolaos, Stathatos, Gilbert H, Daniels
openaire   +2 more sources

Autoimmune Addison’s Disease

2010
Primary adrenocortical insufficiency, or Addison's disease (AD), results from an adrenal cortex hypofunction/dysfunction with a deficient production of glucocorticoids, mineralocorticoids and androgens, and with high levels of both ACTH and plasma renin activity.
BETTERLE, CORRADO, MORLIN L.
openaire   +3 more sources

Infection, autoimmunity and autoimmune disease

1996
Studies of the immune response of mammals to infectious agents have revealed that members of the hsp60 and hsp 70 family are highly immunodominant. Given their high conservation during evolution this was surprising, because of the apparent risk of triggering of autoimmunity and autoimmune disease during the defense of a mammal against infection ...
U, Feige, W, van Eden
openaire   +2 more sources

Autoimmune Thyroid Disease

Annual Review of Medicine, 1986
The concept of thyroid autoimmune disease now includes the following clinical entities: 1 degree thyrotoxicosis and goitrous thyroiditis (Hashimoto) with their variants, and 1 degree myxedema (atrophic thyroiditis); some cases of sporadic nontoxic goiters; most cases of neonatal hyperthyroidism; and a proportion of congenital athyreotic cretinism ...
G F, Bottazzo, D, Doniach
openaire   +2 more sources

Autoimmune Addison's disease

La Presse Médicale, 2012
Addison's disease is a rare autoimmune disorder. In the developed world, autoimmune adrenalitis is the commonest cause of primary adrenal insufficiency, where the majority of patients have circulating antibodies against the key steroidogenic enzyme 21-hydroxylase.
Catherine, Napier, Simon H S, Pearce
openaire   +2 more sources

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