Results 341 to 350 of about 9,515,152 (393)
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Arthritis & Rheumatology, 2019
Immune checkpoint inhibitors (ICIs) for cancer therapy frequently induce immune‐related adverse effects (IRAEs). Therefore, most patients with preexisting autoimmune diseases have been excluded from clinical trials of ICIs.
A. Tison +44 more
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Immune checkpoint inhibitors (ICIs) for cancer therapy frequently induce immune‐related adverse effects (IRAEs). Therefore, most patients with preexisting autoimmune diseases have been excluded from clinical trials of ICIs.
A. Tison +44 more
semanticscholar +1 more source
JAMA: The Journal of the American Medical Association, 1982
SYSTEMIC LUPUS ERYTHEMATOSUS Clinical Features Systemic lupus erythematosus (SLE) is a multisystem disorder characterized by the presence of a variety of autoantibodies that are responsible for immunopathologically mediated tissue injury. It is the prototype for a group of disorders that are referred to as the systemic autoimmune or connective tissue
Peter F. Kohler, John H. Vaughan
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SYSTEMIC LUPUS ERYTHEMATOSUS Clinical Features Systemic lupus erythematosus (SLE) is a multisystem disorder characterized by the presence of a variety of autoantibodies that are responsible for immunopathologically mediated tissue injury. It is the prototype for a group of disorders that are referred to as the systemic autoimmune or connective tissue
Peter F. Kohler, John H. Vaughan
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Type I Interferons in Autoimmune Disease.
Annual Review of Pathology, 2019Type I interferons, which make up the first cytokine family to be described and are the essential mediators of antivirus host defense, have emerged as central elements in the immunopathology of systemic autoimmune diseases, with systemic lupus ...
M. Crow, M. Olferiev, K. Kirou
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JAMA: The Journal of the American Medical Association, 1987
SINCE the earliest descriptions of the immune system, the ability of an individual to react to a wide variety of foreign and endogenous antigens, while not responding to one's own self, has intrigued researchers. The first descriptions of autoimmune phenomena in the early 1900s aroused sufficient anxiety to cause Ehrlich to coin the term "horror ...
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SINCE the earliest descriptions of the immune system, the ability of an individual to react to a wide variety of foreign and endogenous antigens, while not responding to one's own self, has intrigued researchers. The first descriptions of autoimmune phenomena in the early 1900s aroused sufficient anxiety to cause Ehrlich to coin the term "horror ...
openaire +4 more sources
Autoimmunity and Celiac Disease
Mini-Reviews in Medicinal Chemistry, 2008In celiac disease (CD), abnormal immune-mediated responses follow ingestion of gluten. Although the triggering agent is a dietary protein, the disease has autoimmune components because of the presence of autoantibodies and its association with autoimmune conditions.
GIANFRANI C +2 more
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Scientific American, 1965
Publisher Summary This chapter discusses autoimmune diseases. Immunologic response has specific resistance to infectious diseases. Immunity by our present concept is the basis of the biologic uniqueness and integrity of the individual animal. The hallmark of immunity—as distinguished from inflammation in general—is its specificity.
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Publisher Summary This chapter discusses autoimmune diseases. Immunologic response has specific resistance to infectious diseases. Immunity by our present concept is the basis of the biologic uniqueness and integrity of the individual animal. The hallmark of immunity—as distinguished from inflammation in general—is its specificity.
openaire +3 more sources
The Indian Journal of Pediatrics, 2002
Autoimmune liver disorders are inflammatory liver diseases characterised histologically by a dense mononuclear cell infiltrate in the portal tract and serologically by the presence of non-organ and liver specific autoantibodies and increased levels of immunoglobulin G (IgG), in the absence of a known etiology.
Mieli-Vergani, G, Vergani, D
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Autoimmune liver disorders are inflammatory liver diseases characterised histologically by a dense mononuclear cell infiltrate in the portal tract and serologically by the presence of non-organ and liver specific autoantibodies and increased levels of immunoglobulin G (IgG), in the absence of a known etiology.
Mieli-Vergani, G, Vergani, D
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Annals of Internal Medicine, 2018
Checkpoint inhibitors (CPIs) have dramatically increased survival in patients with certain types of cancer (1). To date, 6 CPIs have been approved by the U.S. Food and Drug Administration (FDA). Ipilimumab is a cytotoxic T lymphocyteassociated protein 4 (
N. Abdel-Wahab +3 more
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Checkpoint inhibitors (CPIs) have dramatically increased survival in patients with certain types of cancer (1). To date, 6 CPIs have been approved by the U.S. Food and Drug Administration (FDA). Ipilimumab is a cytotoxic T lymphocyteassociated protein 4 (
N. Abdel-Wahab +3 more
semanticscholar +1 more source
Prevalence of autoimmune disease in women with premature ovarian failure
European journal of contraception & reproductive health care, 2019Objective: The aim of the study was to investigate the relationship between premature ovarian failure and autoimmune disease. Methods: This interdisciplinary prospective study included 52 consecutively recruited women with premature ovarian failure, aged
B. Grossmann +6 more
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Infection, autoimmunity and autoimmune disease
1996Studies of the immune response of mammals to infectious agents have revealed that members of the hsp60 and hsp 70 family are highly immunodominant. Given their high conservation during evolution this was surprising, because of the apparent risk of triggering of autoimmunity and autoimmune disease during the defense of a mammal against infection ...
U. Feige, W. van Eden
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