Results 31 to 40 of about 548,302 (167)

Depression in Autoimmune Diseases [PDF]

, 2016
Up to 50% of patients with autoimmune diseases show an impairment of health-related quality of life and exhibit depression-like symptoms. The immune system not only leads to inflammation in affected organs, but also mediates behavior abnormalities including fatigue and depression-like symptoms.
Pryce, Christopher R, Fontana, Adriano
openaire   +4 more sources

Targeting MCR-3 and membrane biosynthesis: mechanistic insights into pterostilbene-colistin synergy

Microbiology Spectrum
Colistin is a crucial antibiotic for treating infections caused by multidrug-resistant Enterobacterales. However, the emergence of plasmid-mediated mcr genes has significantly compromised their clinical efficacy. Natural adjuvants, such as pterostilbene,
Fei Zeng, Wenjuan Yin, Huilian Duan, Shuxin He, Luying Sun, Jie Zhang, Siming Wang, Feng Liu, Yuangong Zhang   +8 more
doaj   +1 more source

Comprehensive characterization of ubiquitinome of human colorectal cancer and identification of potential survival-related ubiquitination

Journal of Translational Medicine, 2022
Background According to the Global Cancer Statistics in 2020, the incidence and mortality of colorectal cancer (CRC) rank third and second among all tumors.
Wei Zhang, Yan Yang, Liewen Lin, Jingquan He, Jingjing Dong, Bin Yan, Wanxia Cai, Yumei Chen, Lianghong Yin, Donge Tang, Fanna Liu, Yong Dai   +11 more
doaj   +1 more source

Probiotic-derived extracellular vesicles: the next breakthrough in postbiotics for rheumatoid arthritis

Frontiers in Immunology
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by systemic inflammation and joint damage. Emerging evidence highlights the role of gut and oral microbiota in RA pathogenesis, with microbial dysbiosis potentially exacerbating ...
Federica Dell’Atti, Federica Dell’Atti, Hugo Abreu, Hugo Abreu, Patrizia Malfa, Davide Raineri, Davide Raineri, Giuseppe Cappellano, Giuseppe Cappellano, Annalisa Chiocchetti, Annalisa Chiocchetti   +10 more
doaj   +1 more source

Excessive poly(ADP)-ribosylation in the inflamed mucosa of pediatric celiac disease points to a novel inflammatory mechanism and therapeutic target

Molecular and Cellular Pediatrics
Background Celiac disease (CD) is an immune-mediated enteropathy triggered by gluten exposure in genetically susceptible individuals, characterized by chronic intestinal inflammation, epithelial damage, and immune dysregulation.
Tala M. Haddadin, Tarek M. Masannat, Irshad A. Sheikh, Belinda Sun, Connor P. Kelley, Fayez K. Ghishan, Pawel R. Kiela   +6 more
doaj   +1 more source

AKRs confer oligodendrocytes resistance to differentiation-stimulated ferroptosis

Redox Biology
Ferroptosis is a recently characterized form of cell death that has gained attention for its roles in both pathological and physiological contexts. The existence of multiple anti-ferroptotic pathways in both neoplastic and healthy cells, along with the ...
Valentina Saverio, Emanuele Ferrario, Romina Monzani, Mara Gagliardi, Francesco Favero, Davide Corà, Claudio Santoro, Marco Corazzari   +7 more
doaj   +1 more source

Muscle morphology changes over 1-year in patients with rheumatoid arthritis: a prospective cohort study using muscle ultrasound

Advances in Rheumatology
Background Low muscle mass is associated with physical disability in rheumatoid arthritis (RA), highlighting the need for regular muscle assessment.
Leonardo Peterson dos Santos, Rafaela Cavalheiro do Esíprito Santo, Émerson Pena, Stephanie Pilotti, Daniel Nóbrega Moraes, André Luiz Silveira Mallmann, Lucas Denardi Dória, Gabriel Eduardo Grave, Vanessa Hax, Nicole Pamplona Bueno de Andrade, Claiton Viegas Brenol, Odirlei André Monticielo, Rafael Mendonça da Silva Chakr, Ricardo Machado Xavier   +13 more
doaj   +1 more source

The potential roles of herpesvirus and cytomegalovirus in the exacerbation of pemphigus vulgaris

Dermatology Practical & Conceptual, 2018
Background: Among exogenous etiologies, the critical role of microbial agents such as herpesviruses (HSV1/2) and cytomegalovirus (CMV) in triggering and flaring autoimmune conditions such as pemphigus vulgaris (PV) has been recently discovered ...
Fariba Mohammadi, Zahra Khalili, Sayed Mahdi Marashi, Amirhoushang Ehsani, Maryam Daneshpazhooh, Majid Teymoori-Rad, Kamran Balighi, Ahmad Nejati, Shohreh Shahmahmoodi, Shima Izadidakhrabadi, Hamidreza Mahmoudi, Pedram Noormohammadpour   +11 more
doaj   +1 more source

Dysregulation of T Follicular Helper and Regulatory Cells in IRF5-SLE Homozygous Risk Carriers and Systemic Lupus Erythematosus Patients

Cells
T follicular helper (Tfh) and T follicular regulatory cells (Tfr) are required for antibody production and are dysregulated in SLE. Genetic variants within or near interferon regulatory factor 5 (IRF5) are associated with SLE risk. We previously reported
Bharati Matta, Lydia Thomas, Vinay Sharma, Betsy J. Barnes   +3 more
doaj   +1 more source

Priming of rat bone marrow-derived mesenchymal stem cells with curcumin induces an anti-inflammatory M2 phenotype in J774A.1 macrophage cell line

BMC Complementary Medicine and Therapies
Context In recent years, several strategies have been used to enhance mesenchymal stem cells’ (MSCs) immunomodulatory and therapeutic potential. Curcumin (Cur), the main active component of turmeric from the Curcuma longa plant, might improve the ...
Gholamreza Daryabor, Nasim Kheshtchin, Seyede Zahra Hashemi, Fatemeh Rezaei Kahmini, Nasser Gholijani   +4 more
doaj   +1 more source