Results 321 to 330 of about 10,168,516 (390)

Autoimmune Diseases of the Eyelid Skin: Molecular Pathways, Clinical Manifestations, and Therapeutic Insights. [PDF]

Int J Mol Sci
Luboń W, Luboń M, Sarnat-Kucharczyk M, Dorecka M, Wyględowska-Promieńska D.   +4 more
europepmc   +1 more source

Allelic Variation in Maize Malate Dehydrogenase 7 Shapes Promoter Methylation and Banded Leaf and Sheath Blight Resistance

Advanced Science, EarlyView.
In this study maize chloroplastic malate dehydrogenase7 (ZmMDH7), is identified as a Rhizoctonia solani resistance gene in maize. ZmMDH7 is regulated by transcription factor ZmWRKY44 via pathogens challenge to elevate mitochondrial ROS and SA signaling pathway.
Luyang Wei, Junbin Chen, Chuang Liu, DanDan Liu, Meida Du, Shengfeng He, Wenyu Cheng, Vijai Bhadauria, You‐Liang Peng, Wangsheng Zhu   +9 more
wiley   +1 more source

A case of chronic Campylobacter fetus infection-related glomerulonephritis, mimicking systemic autoimmune diseases. [PDF]

CEN Case Rep
Matsumoto M, Kitai Y, Yamamoto S, Iwashige Y, Muro K, Kato Y, Tsuchido Y, Shinohara K, Tsuda Y, Murakami K, Kaneko K, Nakata H, Matsubara T, Yokoi H, Ito I, Minamiguchi S, Oda T, Nagao M, Yanagita M.   +18 more
europepmc   +1 more source

ETV1 Drives CD4+ T Cell‐Mediated Intestinal Inflammation in Inflammatory Bowel Disease Through Amino Acid Transporter Slc7a5

Advanced Science, EarlyView.
This study identifies the transcription factor ETV1 as a key driver of CD4⁺ T cell‐mediated intestinal inflammation in inflammatory bowel disease (IBD). ETV1 promotes CD4⁺ T cell activation, proliferation, and Th17 differentiation by activating the amino acid transporter SLC7A5, fueling metabolic reprogramming.
Yan Shi, Song Wang, Yuqing Yan, Wei Chen, Yingying Cao, Dafan Chen, Wei Chen, Caiyun Ma, Xinjian Wan   +8 more
wiley   +1 more source

The origin of autoimmune diseases: is there a role for ancestral HLA-II haplotypes in immune hyperactivity. [PDF]

Front Immunol
Ruiz-Pablos M, Paiva B, Zabaleta A.
europepmc   +1 more source

Parabiosis, Assembloids, Organoids (PAO)

Advanced Science, EarlyView.
This review evaluates parabiosis, organoids, and assembloids as complementary disease models spanning systemic, organ, and multi‐organ levels. It highlights their construction strategies, applications, and current limitations, while emphasizing their integration with frontier technologies such as artificial intelligence, organ‐on‐a‐chip, CRISPR, and ...
Yang Hong, Lavonda Li, Lijie Yan, Long Bai, Jiacan Su, Xingcai Zhang   +5 more
wiley   +1 more source

Exosomes in Autoimmunity: Mediators of Autoantigen Presentation and Targets for Therapeutic Intervention in Autoimmune Diseases. [PDF]

J Clin Immunol
Almohaimeed HM, Almars AI, Tounsi WA, Mohammedsaleh ZM, Panigrahi R, Singh I, Singh S, Dhara B, Uti DE.   +8 more
europepmc   +1 more source

Precision Editing of NLRS Improves Effector Recognition for Enhanced Disease Resistance

Advanced Science, EarlyView.
Precision engineering of plant NLR immune receptors enables rational design of enhanced pathogen resistance through mismatched pairing, domain swapping, and targeted mutagenesis. These approaches achieve multi‐fold expansion in recognition breadth while minimizing autoimmunity risks and fitness penalties.
Vinit Kumar, Vishwa I. P. W. A. Kumara, Pradeepa C. G. Bandaranayake, Dong Yawen, Yang‐Yang Gao, Junfeng Liu, Ge‐Fei Hao, Xiu‐Fang Xin   +7 more
wiley   +1 more source

Global landscape of autoimmune diseases across different lifespan: A three-decade perspective. [PDF]

Medicine (Baltimore)
Xiao XP, Wu MY, Li Y, Hu X, Qin BY.
europepmc   +1 more source