Results 71 to 80 of about 9,454,943 (225)

The role of tunable activation thresholds in the dynamics of autoimmunity [PDF]

J. Theor. Biol. 308, 45-55 (2012), 2012
It has been known for some time that human autoimmune diseases can be triggered by viral infections. Several possible mechanisms of interactions between a virus and immune system have been analysed, with a prevailing opinion being that the onset of autoimmunity can in many cases be attributed to "molecular mimicry", where linear peptide epitopes ...
arxiv  

Highly Selective Inhibition of Tyrosine Kinase 2 (TYK2) for the Treatment of Autoimmune Diseases: Discovery of the Allosteric Inhibitor BMS-986165.

Journal of Medicinal Chemistry, 2019
Small molecule JAK inhibitors have emerged as a major therapeutic advancement in treating autoimmune diseases. The discovery of isoform selective JAK inhibitors that traditionally target the catalytically active site of this kinase family has been a ...
Stephen T. Wrobleski, R. Moslin, S. Lin, Yanlei Zhang, S. Spergel, J. Kempson, J. Tokarski, J. Strnad, A. Zupa-Fernandez, Lihong Cheng, D. Shuster, Kathleen M. Gillooly, Xiaoxia Yang, Elizabeth M. Heimrich, K. McIntyre, C. Chaudhry, Javed A Khan, M. Ruzanov, J. Tredup, Dawn Mulligan, D. Xie, Huadong Sun, Christine S. Huang, C. D’arienzo, N. Araníbar, M. Chiney, A. Chimalakonda, W. Pitts, L. Lombardo, P. Carter, J. Burke, D. Weinstein   +31 more
semanticscholar   +1 more source

Mayaro: an emerging viral threat?

Emerging Microbes and Infections, 2018
Mayaro virus (MAYV), an enveloped RNA virus, belongs to the Togaviridae family and Alphavirus genus. This arthropod-borne virus (Arbovirus) is similar to Chikungunya (CHIKV), Dengue (DENV), and Zika virus (ZIKV).
Yeny Acosta-Ampudia, Diana M. Monsalve, Yhojan Rodríguez, Yovana Pacheco, Juan-Manuel Anaya, Carolina Ramírez-Santana   +5 more
doaj   +1 more source

IRF5 suppresses metastasis through the regulation of tumor-derived extracellular vesicles and pre-metastatic niche formation

Scientific Reports
Metastasis is driven by extensive cooperation between a tumor and its microenvironment, resulting in the adaptation of molecular mechanisms that evade the immune system and enable pre-metastatic niche (PMN) formation.
Bailey K. Roberts, Dan Iris Li, Carter Somerville, Bharati Matta, Vaishali Jha, Adison Steinke, Zarina Brune, Lionel Blanc, Samuel Z. Soffer, Betsy J. Barnes   +9 more
doaj   +1 more source

Integrative genetic risk prediction using nonparametric empirical Bayes classification [PDF]

, 2016
Genetic risk prediction is an important component of individualized medicine, but prediction accuracies remain low for many complex diseases. A fundamental limitation is the sample sizes of the studies on which the prediction algorithms are trained.
arxiv   +1 more source

Neurological Consequences of COVID-19 Infection [PDF]

arXiv, 2021
COVID-19 infections have well described systemic manifestations, especially respiratory problems. There are currently no specific treatments or vaccines against the current strain. With higher case numbers, a range of neurological symptoms are becoming apparent.
arxiv  

Immunological and clinical effects of low-dose interleukin-2 across 11 autoimmune diseases in a single, open clinical trial

Annals of the Rheumatic Diseases, 2018
Objective Regulatory T cells (Tregs) prevent autoimmunity and control inflammation. Consequently, any autoimmune or inflammatory disease reveals a Treg insufficiency.
M. Rosenzwajg, R. Lorenzon, P. Cacoub, H. Pham, F. Pitoiset, Karim El Soufi, C. Ribet, C. Bernard, S. Aractingi, B. Banneville, L. Beaugerie, F. Berenbaum, J. Champey, O. Chazouilleres, C. Corpechot, B. Fautrel, A. Mékinian, E. Regnier, D. Saadoun, J. Salem, J. Sellam, P. Seksik, A. Daguenel-Nguyen, V. Doppler, Jérémie Mariau, E. Vicaut, D. Klatzmann   +26 more
semanticscholar   +1 more source

Roles of GM-CSF in the Pathogenesis of Autoimmune Diseases: An Update

Frontiers in Immunology, 2019
Granulocyte-macrophage colony-stimulating factor (GM-CSF) was first described as a growth factor that induces the differentiation and proliferation of myeloid progenitors in the bone marrow.
Noushin Lotfi, R. Thome, N. Rezaei, Guang-Xian Zhang, A. Rezaei, A. Rostami, N. Esmaeil   +6 more
semanticscholar   +1 more source

Autoimmune Bullous Disease Quality of Life (ABQoL) questionnaire: Validation of the translated Persian version in pemphigus vulgaris

International Journal of Women's Dermatology, 2020
Background: Autoimmune bullous diseases are a group of rare, chronic, blistering diseases, with pemphigus vulgaris (PV) being the most common type in Iran.
Amir Teimourpour, PhD, Kowsar Hedayat, MD, Fereshteh Salarvand, MD, Narges Ghandi, MD, Maryam Ghiasi, MD, Hamidreza Mahmoudi, MD, Kamran Balighi, MD, Roja Toosi, MD, MPH, Farnam Mohebi, MD, MPH, Ali Nili, MD, Maryam Daneshpazhooh, MD, Dedee F. Murrell, MA, BMBCh, MD, FACD, Cheyda Chams-Davatchi, MD   +12 more
doaj  

Modeling the influence of TH1 and TH2 type cells in autoimmune diseases [PDF]

arXiv, 2000
A sharp TH1/TH2 dichotomy has often been used to define the effects of cytokines on autoimmune diseases. However contradictory results in recent research indicate that the situation may be more complex. We build here a simple mathematical model aimed at settling the contradictions.
arxiv