Results 71 to 80 of about 9,729,179 (262)

Enhanced cytotoxic effect of camptothecin nanosponges in anaplastic thyroid cancer cells in vitro and in vivo on orthotopic xenograft tumors

Drug Delivery, 2017
Anaplastic carcinoma of the thyroid (ATC) is a lethal human malignant cancer with median survival of 6 months. To date, no treatment has substantially changed its course, which makes urgent need for the development of novel drugs or novel formulations ...
Casimiro Luca Gigliotti, Benedetta Ferrara, Sergio Occhipinti, Elena Boggio, Giuseppina Barrera, Stefania Pizzimenti, Mirella Giovarelli, Roberto Fantozzi, Annalisa Chiocchetti, Monica Argenziano, Nausicaa Clemente, Francesco Trotta, Caterina Marchiò, Laura Annaratone, Renzo Boldorini, Umberto Dianzani, Roberta Cavalli, Chiara Dianzani   +17 more
doaj   +1 more source

Carnosol Modulates Th17 Cell Differentiation and Microglial Switch in Experimental Autoimmune Encephalomyelitis [PDF]

, 2018
Medicinal plants as a rich pool for developing novel small molecule therapeutic medicine have been used for thousands of years. Carnosol as a bioactive diterpene compound originated from Rosmarinus officinalis (Rosemary) and Salvia officinalis, herbs ...
Fei Zhang, Guang-Xian Zhang, Juan-Juan Han, Li Zhao, Lin Zhu, Shuai Liu, Xing Li, Xing Li, Yuan Zhang, Yuan Zhang, Zhe-Zhi Wang   +10 more
core   +3 more sources

Shared genetic variants suggest common pathways in allergy and autoimmune diseases. [PDF]

, 2016
BACKGROUND: The relationship between allergy and autoimmune disorders is complex and poorly understood. OBJECTIVE: To investigate commonalities in genetic loci and pathways between allergy and autoimmune diseases to elucidate shared disease mechanisms ...
Adnan Custovic, Alan James, Alexessander Couto Alves, Ananieva, Andersson, Angela Simpson, Bach, Barrett, Bergamaschi, Bhatt, Bønnelykke, Carla M.T. Tiesler, Chen, Chevalier, Clark, Cotsapas, Cotsapas, Craig E. Pennell, David Hinds, David P. Strachan, Dirkje S. Postma, Du, Elaine Fuertes, Elangovan, Eskil Kreiner, Farh, Ferreira, Ferreira, Franke, Fujita, Gerard H. Koppelman, Gohlke, Gudbjartsson, Han, Hans Bisgaard, Hinds, Hirota, Jeffery, Joel N. Hirschhorn, Johannes Waage, John Henderson, Jostins, Joyce Y. Tung, Klaus Bønnelykke, Koch, Kofler, Lango Allen, Lee, Li, Lloyd, Lude Franke, Maier, Manuel A. Ferreira, Marie Standl, Marjo-Riitta Jarvelin, Maurano, Mells, Moffatt, Nair, Nicholas Timpson, Nicole M. Warrington, Palmer, Paternoster, Pers, Petukhova, Pittet, Rabin, Rudwaleit, Sawcer, Sevelsted, Sirota, Stahl, Steinman, Susanne Brix, Tak, Takimoto, Terrados, Tune H. Pers, Urayama, Verhoef, Wang, Welter, Yan, Yoshida, Zhernakova   +84 more
core   +4 more sources

A Comprehensive Review on HIV-Associated Dermatologic Manifestations: From Epidemiology to Clinical Management

International Journal of Microbiology, 2023
Dermatological disorders are among the most prevalent manifestations of HIV infection/acquired immunodeficiency syndrome (AIDS). In this review, we aimed to characterize the various dermatologic presentations among HIV-infected patients with a detailed ...
Zeinab Mohseni Afshar, Azadeh Goodarzi, Seyed Naser Emadi, Ronak Miladi, Safoura Shakoei, Alireza Janbakhsh, Zeinab Aryanian, Parvaneh Hatami   +7 more
doaj   +1 more source

Glassy Dynamics in the Adaptive Immune Response Prevents Autoimmune Disease [PDF]

, 2005
The immune system normally protects the human host against death by infection. However, when an immune response is mistakenly directed at self antigens, autoimmune disease can occur. We describe a model of protein evolution to simulate the dynamics of the adaptive immune response to antigens.
arxiv   +1 more source

graph-GPA 2.0: A Graphical Model for Multi-disease Analysis of GWAS Results with Integration of Functional Annotation Data [PDF]

arXiv, 2022
Genome-wide association studies (GWAS) have successfully identified a large number of genetic variants associated with traits and diseases. However, it still remains challenging to fully understand functional mechanisms underlying many associated variants. This is especially the case when we are interested in variants shared across multiple phenotypes.
arxiv  

Clinicopathological Spectrum of Facial Granulomatous Dermatoses: Evidence from a 5-Year Study in Iran

Dermatology Research and Practice
Background. Granulomatous dermatoses, particularly on facial skin, pose a diagnostic challenge, as similar histologic patterns can be produced by different causes. Aim. To evaluate the correlation between clinical suspicion and histopathological findings
Zeinab Aryanian, Mahshid Ansari, Huda Fatima, Mona Homayouni, Azadeh Khayyat, Alireza Ghanadan, Parvaneh Hatami   +6 more
doaj   +1 more source

Family impact of pemphigus disease in an Iranian population using the Family Dermatology Life Quality Index

International Journal of Women's Dermatology, 2020
Background: Pemphigus vulgaris (PV) is a rare but seriously disabling disorder of the skin and mucous membranes that can gravely impact the quality of life (QoL) of patients.
S. Zahra Ghodsi, MD, Arefeh Asadi, MD, Narges Ghandi, MD, Kamran Balighi, MD, Hamidreza Mahmoudi, MD, Robabeh Abedini, MD, Maryam Ghiasi, MD, Vahideh Lajevardi, MD, Cheyda Chams-Davatchi, MD, Maryam Daneshpazhooh, MD   +9 more
doaj  

JAK–STAT Signaling as a Target for Inflammatory and Autoimmune Diseases: Current and Future Prospects

Drugs, 2017
The Janus kinase/signal transduction and activator of transcription (JAK–STAT) signaling pathway is implicated in the pathogenesis of inflammatory and autoimmune diseases including rheumatoid arthritis, psoriasis, and inflammatory bowel disease.
Shubhasree Banerjee, A. Biehl, M. Gadina, S. Hasni, D. Schwartz   +4 more
semanticscholar   +1 more source

Depression in autoimmune diseases [PDF]

, 2016
Up to 50% of patients with autoimmune diseases show an impairment of health-related quality of life and exhibit depression-like symptoms. The immune system not only leads to inflammation in affected organs, but also mediates behavior abnormalities ...
Pryce, Christopher R, Fontana, Adriano
core   +1 more source