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Management of autoimmune encephalitis
Current Opinion in Neurology, 2021Purpose of review Autoimmune encephalitides are established diagnoses in contemporary neurology. Their management poses a regular challenge for almost all neurologists. One may ask if the concept of 1st line and 2nd line treatment is still up to date, which new data on the antibody-defined encephalitis types exist, and how to ...
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Autoimmune encephalitis with autoimmune myocarditis
BMJ Case ReportsAutoimmune encephalitis can be associated with other autoimmune disorders, but the concurrent presence of autoimmune encephalitis and autoimmune myocarditis is uncommon. A man in his 80s with type 2 diabetes mellitus, hypertension and hypothyroidism presented with altered mental status for 8 months.
Anuraag Gattu +7 more
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Neurobiology of autoimmune encephalitis
Current Opinion in Neurobiology, 2018Autoimmune encephalitis presenting with amnesia, seizures, and psychosis is highly topical in basic and clinical neuroscience. Recent studies have identified numerous associated autoantibodies, targeting cell-surface synaptic proteins including neurotransmitter receptors (e.g. NMDA receptors (NMDARs)) and a secreted protein, LGI1.
Masaki, Fukata +2 more
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Autoimmune limbic encephalitis
Acta Neurologica Scandinavica, 2009Autoimmune limbic encephalitis (LE) can arise both by paraneoplastic and non-paraneoplastic mechanisms. Patients with LE usually have a subacute onset of memory impairment, disorientation and agitation, but can also develop seizures, hallucinations and sleep disturbance.
C A, Vedeler, A, Storstein
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Autoimmune-mediated encephalitis
Neuroradiology, 2011Autoimmune-mediated encephalitis may occur as a paraneoplastic or as a non-paraneoplastic condition. The role of neuroimaging in autoimmune-mediated encephalitis has changed in the last decade partly due to improvements in sequence optimisation and higher field strength and partly due to the discovery of an increasing number of antibodies to neuronal ...
Philippe, Demaerel +5 more
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Mechanisms of autoimmune encephalitis
Current Opinion in NeurologyPurpose of review To provide an overview of the pathogenic mechanisms involved in autoimmune encephalitides mediated by antibodies against neuronal surface antigens, with a focus on NMDAR and LGI1 encephalitis. Recent findings In antibody-mediated encephalitides, binding of IgG ...
Claudia, Papi +2 more
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Another autoimmune encephalitis?
Neurology, 2015Over the last decade, the discovery of neurologic disorders associated with antibodies directed against extracellular CNS antigens located on cellular surfaces and synaptic epitopes has revolutionized the diagnosis, therapy, and prognosis of a spectrum of conditions formerly unknown or mischaracterized.
Steiner I, Rüegg S
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Neuroglia in autoimmune encephalitis
Neuroglial cells play a crucial role in central nervous system (CNS) health and disease. Antibody-associated autoimmune encephalitis (AE) represents a group of inflammatory brain diseases with antibodies (Abs) against neuronal cell surface (e.g., anti-N-methyl-d-aspartate receptor (NMDAR), anti-leucine-rich glioma-inactivated 1 (LGI1), γ-aminobutyric ...Fatme Seval, Ismail +3 more
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Immunotherapies on autoimmune encephalitis
Autoimmune encephalitis (AE) is a heterogeneous inflammatory syndrome caused by autoantibodies targeted at either neuronal cell surface proteins and synaptic receptors, or at intracellular epitopes. Clinical presentation is dependent on the underlying neuronal antigen, typically involving subacute progressive cognitive deficits, psychiatric and ...Cynthia M C, Lemmens +2 more
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