Results 131 to 140 of about 30,364 (243)

Single‐Cell and Spatial Omics: Methods and Applications

MedComm, Volume 7, Issue 4, April 2026.
Systematically summarized the breakthrough sequencing technologies and computational methods for single‐cell and spatial omics across multiple omics layers, including genome, epigenome, transcriptome, proteome, and metabolome. State‐of‐the‐art methods for multi‐omics integration, cross‐modal integration, and cross‐scale integration were reviewed, with ...
Xiaoping Cen, Xiaolan Huang, Enjin Deng, Xue Gong, Na Tan, Jifeng Ye, Yin Wang, Roland Eils, Qun Luo, Yixue Li, Fangfang Qu   +10 more
wiley   +1 more source

Post‐translational Modifications in Proteins: Prediction Methods, Biological Functions, and Diseases

MedComm, Volume 7, Issue 4, April 2026.
Posttranslational modifications (PTMs) serve as rapid and reversible molecular switches that reshape protein activity, stability, and interactomes, thereby governing virtually all physiological cues ranging from signal transduction to epigenetic memory. Mass spectrometry‐based proteomics has substantially expanded our understanding of PTM emergence and
Shuning Zhang, Jingmin Li, Meihuan Chen, Hailong Huang   +3 more
wiley   +1 more source

Rheumatoid Arthritis–Associated Pleural Effusion in an Elderly Female With Multimorbidity: A Case Report and Diagnostic Challenge

Respirology Case Reports, Volume 14, Issue 4, April 2026.
RA Pleural Effusion is a rare but clinically significant extra‐articular manifestation of RA, presenting diagnostic challenges in patients with multimorbidity. This case underscores the importance of considering autoimmune aetiologies in unexplained exudative pleural effusions, particularly when accompanied by joint symptoms or seropositivity.
Aatif Syed, Abdul Kalam Rawther, Pranav Kumar   +2 more
wiley   +1 more source

Novel immunotherapies for immune-mediated haemolytic anaemia in dogs and people [PDF]

, 2015
Aerts, Ahmad, Andre, Baek, Baker, Baluna, Barcellini, Bardwell, Barker, Barker, Barker, Bennett, Berentsen, Bielekova, Brode, Brunkow, Buckner, Cancro, Cao, Castela, Corato, Den Otter, Desreumaux, Dieckmann, Dowling, Ellis, Forrester, Gagliani, Garden, Ginzler, Graca, Grant, Grundy, Haagsman, Haase, Hall, Hall, Han, Herzog, Heylmann, Hoffmann, Hori, Hori, Humrich, Impellizeri, Ito, James W Swann, Jubala, Jutel, Keiserman, Kim, Klatzmann, Knueppel, Kojima, Komatsu, Konietschke, Lutz, Mahevas, Mahevas, Marek-Trzonkowska, Mason, McCullough, Meiler, Miller, Miyara, Mouchess, Moyo, Mqadmi, Mueller, Oliver A Garden, Olivry, Packman, Penalver, Pinheiro, Polyak, Putnam, Reff, Reimer, Reynaud, Ring, Rodriguez, Rose, Rosenstein, Rue, Saadoun, Sabatos-Peyton, Sadlack, Sadlack, Sakaguchi, Schabowsky, Sharfe, Singer, Swann, Swann, Thornton, Tischner, Verhagen, Volkmann, Waldron-Lynch, Ward, Whitley, Wildin, Willerford, Wing, Xiao, Xu, Xu, Yadav, Zaja, Zanella, Zhao, Ziekman   +111 more
core   +2 more sources

Sutimlimab in Patients With Cold Agglutinin Disease (CAD): Results From a Managed Access Program

European Journal of Haematology, Volume 116, Issue 4, Page 409-415, April 2026.
ABSTRACT Cold agglutinin disease (CAD) is a low‐grade lymphoproliferative disorder accounting for 15%–30% of patients suffering from autoimmune hemolytic anemias. The clonal B cells produce autoantibodies primarily of the IgM‐κ class that cause agglutination of red blood cells (RBCs) at temperatures ≤ 37°C and activate the classical complement pathway ...
Sandra Maria Frey, Pauline Halberstadt, Ferras Alashkar, Veronika Lenz, H. Christian Reinhardt, Alexander Röth   +5 more
wiley   +1 more source

Erythrocyte Antibodies in AIDS are associated with mycobacteriosis and hypergammaglobulinemia [PDF]

, 1990
A. Matuschke, AP Rapoport, B. Gathof, B. Heinrich, F. -D. Goebel, FJ Raal, J Lelie van der, J. R. Bogner, L Morris, LI Zon, LI Zon, M Adams, MH McGinniss, P Zauber, PT Toy, PT Toy, PY Lepennec, R Perricone, U. Bäcker, V Daniel, Y Inada, Y Schoenfeld   +21 more
core   +1 more source

Molecular Testing in Sickle Cell Disease: From Newborn Screening to Transfusion Care

International Journal of Laboratory Hematology, Volume 48, Issue 2, Page 295-304, April 2026.
ABSTRACT Sickle cell disease (SCD) is one of the most frequent monogenic diseases worldwide and a highly heterogeneous and complex disease. SCD care carries several challenges. This includes early and accurate diagnosis as well as optimal red blood cell transfusion matching in this population carrying a high risk of alloimmunization.
Thomas Pincez, Yves D. Pastore
wiley   +1 more source

Evaluation of the Diagnostic Accuracy of the Quantitative Point‐of‐Care SD Biosensor Standard G6PD Test for Assessment of G6PD Deficiency in Infectious Diseases

International Journal of Laboratory Hematology, Volume 48, Issue 2, Page 440-446, April 2026.
ABSTRACT Background G6PD deficiency affects about 500 million people worldwide and is prevalent in many malaria‐endemic settings. People with G6PD deficiency are at risk of hemolysis when exposed to certain medications, including 8‐aminoquinoline drugs used to treat Plasmodium vivax malaria.
Flavia Regina Medeiros da Silva, Alexandre Gomes Vizzoni, Daniela Mendes‐de‐Almeida, Joanna Bokel, Raquel de Vasconcellos Carvalhaes de Oliveira, André Machado Siqueira, Yasmine Rangel Vieira, Simone da Costa Cruz Silva   +7 more
wiley   +1 more source

Idiopathic autoimmune hemolytic anemia due to lecithin overdose: a case report [PDF]

, 2009
Ioannis Lentzas, Panagiotis Papagiannopoulos, Ioannis Nikolaidis, Vasiliki Garmiri, Demosthenes Vatides, Athanasia Papathanasiou, Andreas Melidonis, Georgios Tsiros, Panagiota Voila, Christos Lionis   +9 more
core   +1 more source

Epidemiology and Genetics of Rheumatic Diseases Suggest a Constant Rate of DNA Damage as Underlying Cause

Immunology, Volume 177, Issue 4, Page 736-748, April 2026.
A constant rate of DNA damage that is not perfectly repaired will cause a constant rate of DNA mutations. The chance of mutation will increase if DNA is prone to damage, such as occurs in somatic hypermutation (SHM) hotspots and GC‐rich DNA. Thus, if one mutation‐prone DNA site drives disease, the age of onset of disease and degree of penetrance should
Piet C. de Groen
wiley   +1 more source