Results 131 to 140 of about 436,604 (311)

Epidemiology and Genetics of Rheumatic Diseases Suggest a Constant Rate of DNA Damage as Underlying Cause

Immunology, Volume 177, Issue 4, Page 736-748, April 2026.
A constant rate of DNA damage that is not perfectly repaired will cause a constant rate of DNA mutations. The chance of mutation will increase if DNA is prone to damage, such as occurs in somatic hypermutation (SHM) hotspots and GC‐rich DNA. Thus, if one mutation‐prone DNA site drives disease, the age of onset of disease and degree of penetrance should
Piet C. de Groen
wiley   +1 more source

High prevalence of bronchiectasis is linked to HTLV-1-associated inflammatory disease. [PDF]

, 2015
BACKGROUND: Human T-lymphotropic virus type 1 (HTLV-1), a retrovirus, is the causative agent of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) and adult T-cell leukaemia/lymphoma (ATLL).
A Gessain, A Gessain, AH Smith, AM Vine, CR Bangham, D Weycker, E Gotuzzo, EL Murphy, F Okada, Graham P Taylor, H Kawai, H Merle, H Nakamura, IARC Monographs on the Evaluation of Carcinogenic Risk to Humans, J Crofton, JR Orland, K Nishioka, L Einsiedel, L Einsiedel, L Einsiedel, L LaGrenade, M Nagai, M Nakagawa, M Osame, M Sugimoto, M Sugimoto, MA Demontis, MG Flynn, OS Morgan, PJ McShane, S Mita, S Mori, Shohreh Honarbakhsh, T Arakaki, T Kondo, T Matsuda, T Yamashiro, W Matsuyama   +37 more
core   +1 more source

Autoimmune uveitis: risk factors and issues of immunopathogenesis

Медицинская иммунология
We present recent advances in studying the mechanisms of susceptibility to immune-mediated uveitis (IM) and its pathogenesis. Animal models of human uveitis are described in details.
I. V. Shirinsky, V. S. Shirinsky
doaj   +1 more source

Lingual Dyskinesia as the Presenting Feature of Acquired Demyelinating Syndrome: A Case Report and Review of Differential Diagnoses

Journal of Paediatrics and Child Health, EarlyView.
Briana Davis, Ahmed Kaki, Eppie M. Yiu, Emma Macdonald‐Laurs   +3 more
wiley   +1 more source

Clinical proteomics for precision medicine: the bladder cancer case [PDF]

, 2017
Precision medicine can improve patient management by guiding therapeutic decision based on molecular characteristics. The concept has been extensively addressed through the application of –omics based approaches.
Frantzi, Maria, Latosinska, Agnieszka, Merseburger, Axel S., Mischak, Harald, Vlahou, Antonia   +4 more
core   +1 more source

Profile of adalimumab and its potential in the treatment of uveitis

Drug Design, Development and Therapy, 2016
Stephen J Balevic, C Egla Rabinovich Department of Pediatric Rheumatology, Duke University Medical Center, Durham, NC, USA Abstract: Uveitis refers to the presence of intraocular inflammation, and as a strict definition compromises the iris and ciliary ...
Balevic SJ, Rabinovich CE
doaj  

The Immunopathogenesis of uveitis

Frontiers in Medicine
Uveitis encompasses a heterogeneous group of intraocular inflammatory disorders and remains a leading cause of preventable visual loss. Its immunopathogenesis reflects the interplay between a uniquely regulated ocular environment and triggers that breach
Jimin Han, James Harper, David A. Copland, David A. Copland, Panayiotis Maghsoudlou   +4 more
doaj   +1 more source

Adhesion molecules in iris biopsy specimens from patients with uveitis [PDF]

, 1998
BACKGROUND/AIMS: Earlier studies on intraocular tissue have demonstrated that T lymphocytes play a major role in the pathogenesis of uveitis.
Baarsma, G.S. (Seerp), Heij, E.C. (Ellen Carolien) La, Kijlstra Prof. Dr, A., Kuijpers, R.W.A.M. (Robert), Mooy, C.M. (Cornelia), Weiden, M.M. (Marcel) van der   +5 more
core   +2 more sources

Anterior uveitis secondary to type II essential cryoglobulinemia [PDF]

, 2013
Background: The purpose of this report is to describe the association of severe anterior uveitis with type II essential cryoglobulinemia. Findings: A 40-year-old male with a history of psoriatic arthritis presented with severe anterior uveitis associated
Nicholson, Laura, Sobrin, Lucia
core   +1 more source

Low Dose Rapamycin Exacerbates Autoimmune Experimental Uveitis

PLoS ONE, 2012
Rapamycin, a potent immune modulator, is used to treat transplant rejection and some autoimmune diseases. Uveitis is a potentially severe inflammatory eye disease, and 2 clinical trials of treating uveitis with rapamycin are under way. Unexpectedly, recent research has demonstrated that low dose rapamycin enhances the memory T cell population and ...
Zili Zhang, Xiumei Wu, Jie Duan, David Hinrichs, Keith Wegmann, Gary L Zhang, Mark Hall, James T Rosenbaum   +7 more
openaire   +4 more sources