Results 21 to 30 of about 436,604 (311)

Disruption of Intestinal Homeostasis and Intestinal Microbiota During Experimental Autoimmune Uveitis [PDF]

Investigative Ophthalmology and Visual Science, 2019
Purpose We determine the changes in intestinal microbiota and/or disruptions in intestinal homeostasis during uveitis. Methods Experimental autoimmune uveitis (EAU) was induced in B10.RIII mice with coadministration of interphotoreceptor retinoid-binding
Cathleen Janowitz, Yukiko Nakamura, Christina Metea, Abigail Gligor, William W. Yu, Lisa Karstens, James T. Rosenbaum, Mark Asquith, Phoebe Lin   +8 more
openalex   +2 more sources

Therapeutic effect of miR-30b-5p-loaded lentivirus on experimental autoimmune uveitis via inhibiting Notch signaling activation [PDF]

Journal of Translational Medicine
Background Uveitis is a common recurrent autoimmune disease that seriously endangers the visual health of patients. MicroRNAs (miRNAs) are closely related to a series of autoimmune diseases.
Xuewei Yin, Huixia Wei, Lijie Guo, Bin Liu, Yuan Peng, Mengxian Zhou, Yan Qiu, Ruyi Qu, Yane Gao, Qiuxin Wu, Wenjun Jiang, Hongsheng Bi, Dadong Guo   +12 more
doaj   +2 more sources

Exploring the Mechanisms of the Ferroptosis-Related Gene TGFBR1 in Autoimmune Uveitis Based on Machine Learning Models. [PDF]

ACS Omega
Zhang D, Ren H, Xing Y, Chen Z.
europepmc   +3 more sources

Global lactylome reveals lactylation-dependent mechanisms underlying TH17 differentiation in experimental autoimmune uveitis

Science Advances, 2023
Dysregulation of CD4+ T cell differentiation is linked to autoimmune diseases. Metabolic reprogramming from oxidative phosphorylation to glycolysis and accumulation of lactate are involved in this process.
Wei Fan, Xiaotang Wang, Shuhao Zeng, Na Li, Guoqing Wang, Ruonan Li, Siyuan He, Wanqian Li, Jiaxing Huang, Xingran Li, Jiangyi Liu, Shengping Hou   +11 more
semanticscholar   +1 more source

Autoimmunity in uveitis [PDF]

Acta Ophthalmologica, 2018
AbstractPurposeRecent insights into the pathogenesis of immune‐mediated diseases proposed a new classification, which includes autoimmune and auto‐inflammatory diseases. The prevalence of specific autoimmune and auto‐inflammatory diseases in uveitis and/or scleritis is not yet known.
Josianne C. ten Berge, Marco W. J. Schreurs, Paul L. A. van Daele, Aniki Rothova   +3 more
openaire   +2 more sources

Therapeutic Effects of Upadacitinib on Experimental Autoimmune Uveitis: Insights From Single-Cell Analysis

Investigative Ophthalmology and Visual Science, 2023
Purpose This study aimed to elucidate the impact of upadacitinib, a Janus kinase 1 (JAK1)-specific inhibitor, on experimental autoimmune uveitis (EAU) and explore its underlying mechanisms.
Zhaohao Huang, Qi Jiang, Junjie Chen, Xiuxing Liu, Chenyang Gu, Tianyu Tao, Jianjie Lv, Zhaohuai Li, Zuohong Li, W. Su   +9 more
semanticscholar   +1 more source

Apigenin Alleviates Autoimmune Uveitis by Inhibiting Microglia M1 Pro-Inflammatory Polarization

Investigative Ophthalmology and Visual Science, 2023
Purpose Apigenin is a natural small molecule compound widely present in various vegetables and fruits. Recently, Apigenin was reported to inhibit lipopolysaccharide (LPS)-simulated microglial proinflammatory activation.
Nan Shu, Zhi Zhang, Xiaotang Wang, Ruonan Li, Wanqian Li, Xianyang Liu, Qi Zhang, Zhengxuan Jiang, Liming Tao, Li Zhang, Shengping Hou   +10 more
semanticscholar   +1 more source

Cytokines in Autoimmune Uveitis [PDF]

Journal of Interferon & Cytokine Research, 2011
Autoimmune uveitis is a complex group of sight-threatening diseases that arise without a known infectious trigger. The disorder is often associated with immunological responses to retinal proteins. Experimental models of autoimmune uveitis targeting retinal proteins have led to a better understanding of the basic immunological mechanisms involved in ...
Reiko, Horai, Rachel R, Caspi
openaire   +2 more sources

Pattern of Uveitis in a Tertiary Hospital in North Jordan and the Impact of Behcet’s Disease

Journal of Ophthalmology, 2023
Aim. The purpose of this study is to assess the prevalence of autoimmune-mediated uveitis in relation to other diseases and to describe the clinical patterns of uveitis in a single tertiary hospital in north Jordan. Methods.
Khaldoon M. Alawneh, Omar A. Saleh, Mahmoud M. Smadi, Fatima Kamel Ababneh, Ikhlas Hamed Ali Mahmoud, Areje M. Smadi, Diala Alawneh   +6 more
doaj   +1 more source

Progesterone attenuates Th17-cell pathogenicity in autoimmune uveitis via Id2/Pim1 axis

Journal of Neuroinflammation, 2023
Background Autoimmune uveitis (AU) is the most common ophthalmic autoimmune disease (AD) and is characterized by a complex etiology, high morbidity, and high rate of blindness. AU remission has been observed in pregnant female patients.
Xiuxing Liu, Chenyang Gu, Jianjie Lv, Q. Jiang, W. Ding, Zhaohao Huang, Yidan Liu, Yuhan Su, Chun Zhang, Zhuping Xu, Xianggui Wang, W. Su   +11 more
semanticscholar   +1 more source