Results 41 to 50 of about 436,604 (311)

MicroRNAs in the regulation of Th17/Treg homeostasis and their potential role in uveitis

Frontiers in Genetics, 2022
Th17 and regulatory T cells (Tregs) play crucial roles in the pathogenesis of autoimmune diseases. Th17/Treg homeostasis is critically involved in maintaining the immune balance.
Fen Tang, Zhou Zhou, Kongqian Huang, Wen Deng, Jiali Lin, Ruoyun Chen, Min Li, Fan Xu   +7 more
doaj   +1 more source

Describing the Clinical and Laboratory Features and HLA-B Pattern of Adult-Onset Idiopathic Autoimmune Uveitis at a Tertiary Hospital in South India: A Cross-Sectional Study

The Scientific World Journal, 2022
Introduction. There is a scarcity of information available on clinical and laboratory features of adult-onset idiopathic autoimmune uveitis. Therefore, we conducted a single centre descriptive cross-sectional study. Patients and Methods.
Jyothi Visalakshy, Sandeep Surendran, Salil Ganu, Kannisha Shah, C. B. Mithun, Vishal Marwaha, Lalitha Biswas, Niveditha Kartha, Gopal Pillai   +8 more
doaj   +1 more source

Overexpressing Kallistatin Aggravates Experimental Autoimmune Uveitis Through Promoting Th17 Differentiation

Frontiers in Immunology, 2021
Kallistatin or kallikrein-binding protein (KBP) has been reported to regulate angiogenesis, inflammation and tumor progression. Autoimmune uveitis is a common, sight-threatening inflammatory intraocular disease.
Nu Chen, Shuang Chen, Zhihui Zhang, Xuexue Cui, Lingzi Wu, Kailei Guo, Hui Shao, Jian-Xing Ma, Xiaomin Zhang   +8 more
doaj   +1 more source

Equine recurrent uveitis - A spontaneous horse model of uveitis [PDF]

, 2008
Equine recurrent uveitis (ERU) is an autoimmune disease that occurs with a high prevalence (10%) in horses. ERU represents the only reliable spontaneous model for human autoimmune uveitis.
Altmann, Frank, Amann, Barbara, Deeg, Cornelia A., Hauck, Stefanie M., Pompetzki, Dirk, Raith, Albert, Schmalzl, Thomas, Stangassinger, Manfred, Ueffing, Marius   +8 more
core   +1 more source

Long‐lived autoreactive memory CD4+ T cells mediate the sustained retinopathy in chronic autoimmune uveitis

The FASEB Journal, 2023
Chronic uveitis comprises heterogeneous clinical entities characterized by sustained and recurrent intraocular inflammation that is believed to be driven by autoimmune responses.
Nai‐Wen Fan, Qiurong Zhu, Shudan Wang, G. Ortiz, Rachel M. Huckfeldt, Yihe Chen   +5 more
semanticscholar   +1 more source

The associations between interleukin 10 polymorphisms and susceptibility to autoimmune uveitis – a meta-analysis

Central European Journal of Immunology, 2019
Autoimmune uveitis is an ocular inflammatory disease that is associated with genetic factors. Interleukin 10 (IL-10) is an immune-regulatory cytokine of autoimmune diseases. IL-10 is considered a candidate gene for uveitis. We evaluate the association of
Jae Jung, Gwan Song, Jae-Hoon Kim, Sung Choi   +3 more
doaj   +1 more source

Circulating anti-galectin-1 antibodies are associated with the severity of ocular disease in autoimmune and infectious uveitis [PDF]

, 2006
Galectin (Gal)-1, an endogenous lectin found at sites of immune privilege, plays a critical role in the regulation of the immune response. Therapeutic administration of Gal-1 or its genetic delivery suppresses chronic inflammation in experimental models ...
Bianco, German Ariel, Ferrero, Mercedes, Juarez, Claudio P., Luna, José Domingo, Muiño, Juan Carlos, Rabinovich, Gabriel A., Romero, Marta D.   +6 more
core   +1 more source

Progranulin Suppressed Autoimmune Uveitis and Autoimmune Neuroinflammation by Inhibiting Th1/Th17 Cells and Promoting Treg Cells and M2 Macrophages

Neurology: Neuroimmunology & Neuroinflammation, 2022
Background and Objectives Progranulin (PGRN) is an important immune regulatory molecule in several immune-mediated diseases. The objective of this study is to investigate the role of PGRN in uveitis and its counterpart, experimental autoimmune uveitis ...
Chaokui Wang, Wenjun Zhou, Guannan Su, Jianping Hu, Peizeng Yang   +4 more
semanticscholar   +1 more source

Type I Interferon Therapy Limits CNS Autoimmunity by Inhibiting CXCR3-Mediated Trafficking of Pathogenic Effector T Cells

Cell Reports, 2019
Summary: Type I interferons (IFNs) have therapeutic potential in CNS autoimmune diseases, such as uveitis, but the molecular mechanisms remain unclear.
Weiwei Wang, Wai Po Chong, Chunmei Li, Zilin Chen, Sihan Wu, Hongyan Zhou, Ying Wan, Wanjun Chen, Igal Gery, Yizhi Liu, Rachel R. Caspi, Jun Chen   +11 more
doaj   +1 more source

PATTERN OF ANTERIOR UVEITIS IN KMN EYECARE

IJRETINA (International Journal of Retina), 2023
Introduction: Anterior uveitis is the most common form of uveitis, but there are relatively few anterior uveitis studies in Indonesia. The purpose of this study is to analyze the pattern of anterior uveitis in KMN EyeCare.
Kevin Kevin, Rifna Lutfiamida
doaj   +1 more source