Results 51 to 60 of about 436,604 (311)

Effect of small extracellular vesicles derived from IL-10-overexpressing mesenchymal stem cells on experimental autoimmune uveitis

Stem cell research & therapeutics, 2022
Autoimmune uveitis is a sight-threatening intraocular inflammation mainly caused by immune dysregulation. The development of safe and effective therapeutic approaches is urgently needed.
Yongtao Li, X. Ren, Zhihui Zhang, Y. Duan, Huan Li, Shuang Chen, H. Shao, Xiaorong Li, Xiaomin Zhang   +8 more
semanticscholar   +1 more source

Horses with equine recurrent uveitis have an activated CD4+ T-cell phenotype that can be modulated by mesenchymal stem cells in vitro. [PDF]

, 2020
Equine recurrent uveitis (ERU) is an immune-mediated disease causing repeated or persistent inflammatory episodes which can lead to blindness. Currently, there is no cure for horses with this disease.
Bellone, Rebecca R, Borjesson, Dori L, Lassaline, Mary, Mack, Maura, Nelson, Seldy G, Saldinger, Laurel K, Walker, Naomi J   +6 more
core   +1 more source

Melatonin, an endogenous hormone, modulates Th17 cells via the reactive-oxygen species/TXNIP/HIF-1α axis to alleviate autoimmune uveitis

Journal of Neuroinflammation, 2022
Background Melatonin, an indoleamine produced by the pineal gland, plays a pivotal role in maintaining circadian rhythm homeostasis. Recently, the strong antioxidant and anti-inflammatory properties of melatonin have attracted attention of researchers ...
D. Liang, Jun Huang, Zhuang Li, Yunwei Hu, Zu-Bing Li, Yanling Xie, Haixiang Huang, Qian Chen, Guanyu Chen, Wenjie Zhu, Yuxi Chen, W. Su, Xiaoqing Chen   +12 more
semanticscholar   +1 more source

Therapeutic Effect of Rapamycin-Loaded Small Extracellular Vesicles Derived from Mesenchymal Stem Cells on Experimental Autoimmune Uveitis

Frontiers in Immunology, 2022
Autoimmune uveitis is a major cause of vision loss and glucocorticoids are major traditional medications, which may induce serious complications. Rapamycin has been demonstrated to exhibit immunosuppressive effects and is promising to be used in treating
Huan Li, Zhihui Zhang, Yongtao Li, Lin Su, Y. Duan, Hui Zhang, Jinying An, Tian-shu Ni, Xiaorong Li, Xiaomin Zhang   +9 more
semanticscholar   +1 more source

Clinical Variations of Uveitis in Immuno-Inflammatory Diseases. Review of the Literature. Part 1

Oftalʹmologiâ, 2022
Non-infectious uveitis is one of the main and insufficiently studied causes of disability and blindness in patients with immuno-inflammatory diseases. Uveitis associated with spondyloarthritis, Behcet’s disease, juvenile idiopathic arthritis, systemic ...
G. A. Davydova, T. A. Lisitsyna, L. A. Kovaleva, E. S. Sorozhkina, A. A. Zaitseva, A. A. Baisangurova   +5 more
doaj   +1 more source

Profound Re-Organization of Cell Surface Proteome in Equine Retinal Pigment Epithelial Cells in Response to In Vitro Culturing [PDF]

, 2012
The purpose of this study was to characterize the cell surface proteome of native compared to cultured equine retinal pigment epithelium (RPE) cells. The RPE plays an essential role in visual function and represents the outer blood-retinal barrier.
Aisenbrey, Alcazar, Alge, Bhutto, Bodaghi, Burke, Campochiaro, Christoph Szober, Chu, Claudia Alge-Priglinger, Clegg, Cornelia Deeg, Deeg, Deeg, Deeg, Deeg, Deeg, Degroote, Doherty, Dunn, Eberhardt, Ehrenhofer, Greer, Gullapalli, Gundersen, Ham, Hamel, Hauck, Hauck, Hauck, Hauck, Ho, Huang, Karl, Kerstin Euler, Kristina Fröhlich, Li, Limb, Machemer, Marius Ueffing, McBee, Milyushina, Mochizuki, Muramatsu, Nagai, Parker, Philp, Rizzolo, Rotilio, Singer, Stefanie Hauck, Strauss, Vacanti, Wolf, Wu   +54 more
core   +3 more sources

Aging weakens Th17 cell pathogenicity and ameliorates experimental autoimmune uveitis in mice

Protein & Cell, 2021
Aging-induced changes in the immune system are associated with a higher incidence of infection and vaccination failure. Lymph nodes, which filter the lymph to identify and fight infections, play a central role in this process.
He Li, Lei Zhu, Rong Wang, Lihui Xie, Jie Ren, Shuai Ma, Weiqi Zhang, Xiuxing Liu, Zhaohao Huang, Binyao Chen, Zhaohuai Li, Huyi Feng, Guang-Hui Liu, Si Wang, J. Qu, W. Su   +15 more
semanticscholar   +1 more source

Associations of Independent IL2RA Gene Variants with Intermediate Uveitis. [PDF]

PLoS ONE, 2015
The genetic background for the concomitance of uveitis and other autoimmune diseases remains elusive. Here the role of two IL2RA gene variants (rs11594656 and rs12722495) was investigated in intermediate uveitis and HLAB27 acute anterior uveitis.One ...
Ewald Lindner, Martin Weger, Navid Ardjomand, Wilfried Renner, Yosuf El-Shabrawi   +4 more
doaj   +1 more source

No association of CTLA-4 polymorphisms with susceptibility to Behcet disease [PDF]

, 2009
Background: Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) is a key negative regulator of T lymphocytes and has been shown to be associated with a number of autoimmune diseases. The present study was performed to assess the association between CTLA-
Du, L., Hou, S., Kijlstra, A., Yang, P., Zhou, H.   +4 more
core   +2 more sources

Cytokines that Modulate the Differentiation of Th17 Cells in Autoimmune Uveitis

Journal of Immunological Research, 2021
Increasing evidence has suggested that T helper 17 (Th17) cells play a central role in the pathogenesis of ocular immune disease. The association between pathogenic Th17 cells and the development of uveitis has been confirmed in experimental and clinical
Kailei Guo, Xiaomin Zhang
semanticscholar   +1 more source