Results 111 to 120 of about 339,261 (412)

The roles of metabolic profiles and intracellular signaling pathways of tumor microenvironment cells in angiogenesis of solid tumors

Cell Communication and Signaling, 2022
Innate and adaptive immune cells patrol and survey throughout the human body and sometimes reside in the tumor microenvironment (TME) with a variety of cell types and nutrients that may differ from those in which they developed.
Hamidreza Zalpoor, Fatemeh Aziziyan, Mahsa Liaghat, Maryam Bakhtiyari, Abdullatif Akbari, Mohsen Nabi-Afjadi, Razieh Forghaniesfidvajani, Nima Rezaei   +7 more
doaj   +1 more source

Prolactin and Autoimmunity

Frontiers in Immunology, 2018
The great asymmetry of autoimmune diseases between genders represents one of the most enigmatic observations among the mosaic of autoimmunity. Sex hormones are believed to play a crucial role on this dimorphism.
V. Borba, G. Zandman-Goddard, Y. Shoenfeld   +2 more
semanticscholar   +1 more source

Mucosa-Environment Interactions in the Pathogenesis of Rheumatoid Arthritis [PDF]

, 2019
Mucosal surfaces play a central role in the pathogenesis of rheumatoid arthritis (RA). Several risk factors, such as cigarette smoking, environmental pollution, and periodontitis interact with the host at the mucosal level, triggering immune system ...
Conti, Fabrizio, Di Franco, Manuela, Guzzo, Maria Paola, Iannuccelli, Cristina, Lucchino, Bruno, Spinelli, Francesca Romani   +5 more
core   +1 more source

ADAPT NXT: Fixed Cycles or Every‐Other‐Week IV Efgartigimod in Generalized Myasthenia Gravis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This phase 3b, open‐label, randomized ADAPT NXT study investigated the efficacy, safety, and tolerability of efgartigimod administered in either a fixed cycles dosing regimen (3 cycles of 4 once‐weekly infusions, with 4 weeks between cycles) or a cycle followed by every‐other‐week (Q2W) dosing.
Ali A. Habib, Kristl G. Claeys, Vera Bril, Yessar Hussain, Kelly Gwathmey, Gregory Sahagian, Elena Cortés‐Vicente, Edward Brauer, Deborah Gelinas, Anne Sumbul, Rosa H. Jimenez, Daniela Hristova, Delphine Masschaele, Renato Mantegazza, Andreas Meisel, Shahram Attarian, On behalf of the ADAPT NXT Study Group   +16 more
wiley   +1 more source

The role of tunable activation thresholds in the dynamics of autoimmunity [PDF]

J. Theor. Biol. 308, 45-55 (2012), 2012
It has been known for some time that human autoimmune diseases can be triggered by viral infections. Several possible mechanisms of interactions between a virus and immune system have been analysed, with a prevailing opinion being that the onset of autoimmunity can in many cases be attributed to "molecular mimicry", where linear peptide epitopes ...
arxiv  

Differential action of TIGIT on islet and peripheral nerve autoimmunity in the NOD mouse [PDF]

arXiv, 2023
We previously demonstrated that the abrogation of the ICOS pathway prevents type 1 diabetes development in the Non Obese Diabetic (NOD) mouse, but results in a CD4+ T-cell dependent autoimmune neuromyopathy in aged mice. Pancreatic islet infiltrates in conventional NOD mice and neuromuscular infiltrates in Icosl-/- NOD mice have in common that they ...
arxiv  

Sarcoidosis as an Autoimmune Disease

Frontiers in Immunology, 2020
Despite the large number of performed studies, the etiology and pathogenesis of sarcoidosis still remain unknown. Most researchers allude to the possible autoimmune or immune-mediated genesis of the disease.
Anna A. Starshinova, Anna M. Malkova, Natalia Y. Basantsova, Natalia Y. Basantsova, Yulia S. Zinchenko, Yulia S. Zinchenko, Igor V. Kudryavtsev, Igor V. Kudryavtsev, Igor V. Kudryavtsev, Gennadiy A. Ershov, Lidia A. Soprun, Vera A. Mayevskaya, Leonid P. Churilov, Leonid P. Churilov, Piotr K. Yablonskiy, Piotr K. Yablonskiy   +15 more
doaj   +1 more source

Correction to: Lymphocyte subset abnormalities in early diffuse cutaneous systemic sclerosis

Arthritis Research & Therapy, 2021
An amendment to this paper has been published and can be accessed via the original article.
David A. Fox, Steven K. Lundy, Michael L. Whitfield, Veronica Berrocal, Phillip Campbell, Stephanie Rasmussen, Ray Ohara, Alexander Stinson, Mikel Gurrea-Rubio, Evan Wiewiora, Catherine Spino, Erica Bush, Daniel Furst, Shiv Pillai, Dinesh Khanna   +14 more
doaj   +1 more source

Oxysterols in Autoimmunity [PDF]

International Journal of Molecular Sciences, 2019
Cholesterol is a member of the sterol family that plays essential roles in biological processes, including cell membrane stability and myelin formation. Cholesterol can be metabolized into several molecules including bile acids, hormones, and oxysterols. Studies from the last few decades have demonstrated that oxysterols are not only active metabolites
Donovan Duc, Solenne Vigne, Caroline Pot
openaire   +3 more sources

Discontinuation of Immunotherapy in Patients With Relapsing Myelitis Without AQP4/MOG Antibodies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT This study assesses the outcomes of immunotherapy discontinuation in patients with relapsing seronegative idiopathic myelitis (SIM), a condition that remains uninvestigated due to its rarity. We reviewed records from 77 patients with relapsing SIM at the National Cancer Center of Korea, focusing on 11 who discontinued treatment after a median ...
Ki Hoon Kim, You‐Ri Kang, Jae‐Won Hyun, Su‐Hyun Kim, Ho Jin Kim   +4 more
wiley   +1 more source