Results 261 to 270 of about 296,707 (334)

Specific autoimmunity in rheumatoid arthritis - T cells, antibodies and genetic regulation

, 2011
Omri Snir
openalex  

TMEM131‐Mediated Soluble TRAIL Triggered Type II Alveolar Epithelial Cell Senescence in Radiation‐Induced Lung Injury

Advanced Science, EarlyView.
TMEM131 recruits the COPII complex to accelerate TRAIL transportation from endoplasmic reticulum to Golgi apparatus, and promotes soluble TRAIL secretion. TRAIL inhibits mitophagy and induces senescence through DR5 receptor in type II alveolar epithelial cells, ultimately driving radiation‐induced lung injury (RILI) progression.
Linzhi Han, Chunsheng Wang, Xiuli Guo, Yuan Luo, Jianguo Zhang, Fajian He, Zihang Zeng, Jiang Luo, Wen Ouyang, Yan Gong, Conghua Xie   +10 more
wiley   +1 more source

Regulatory T Cell-Based Adoptive Cell Therapy in Autoimmunity. [PDF]

Int J Mol Sci
Gozálvez E, Lario A, Muñoz-Sánchez G, Lozano F.   +3 more
europepmc   +1 more source

Mitochondrial DNA oxidation propagates autoimmunity by enabling plasmacytoid dendritic cells induce Tfh differentiation [PDF]

Michael Karin, Hongxu Xian, Masafumi Ohira, Kosuke Watari, Juan P. Brito, Janset Onyuru, Elina I. Zúñiga, Hal M. Hoffman   +7 more
openalex   +1 more source

Targeted Enrichment of Engineered Bacteria on Triple‐Negative Breast Cancer Turns Immunologically Cold Tumors Hot

Advanced Science, EarlyView.
In this study, an “all‐in‐one” engineered anaerobic bacterial system (PDAEcN/COS) is developed for the treatment of immunologically “cold” TNBC. This nanoplatform is capable of colonizing tumor cell surfaces and implementing “self‐blocking” of immune checkpoints, while simultaneously suppressing tumor cells' “don't eat me” signals and delivering “eat ...
Xuanxiang Zhai, Xiaoyi Shi, Xiao Liu, Xiaotong Gu, Wenting Li, Xiangjun Chen, Wei Hong   +6 more
wiley   +1 more source

Environmental Mechanisms Influencing the Pathogenesis and Progression of Type 1 Diabetes. [PDF]

Int J Mol Sci
Tang Y, Wang W, Huang Z, Zhang C, Zhang J, Pang Y, Li S.   +6 more
europepmc   +1 more source

Regulation of autoimmunity and integrin signaling by adaptor proteins ADAP, PRAM-1 and C-CBL

, 2008
Liangxing Zou
openalex   +1 more source

Development of Age‐ and Sex‐Specific Metabolomics‐Based Biological Ageing Clocks for 10‐Year Mortality Prediction

Advanced Science, EarlyView.
Metabolomics‐based ageing clocks developed using blood biomarkers from over 215 000 European adults, improved the prediction of 10‐year all‐cause mortality compared to traditional models. Biological age acceleration is associated with higher mortality risk, as each additional year of metabolic age corresponded to at least 8% increased risk. These tools
Lei Peng, Ruijie Xie, Bernd Holleczek, Hermann Brenner, Ben Schöttker   +4 more
wiley   +1 more source

Allelic Variation in Maize Malate Dehydrogenase 7 Shapes Promoter Methylation and Banded Leaf and Sheath Blight Resistance

Advanced Science, EarlyView.
In this study maize chloroplastic malate dehydrogenase7 (ZmMDH7), is identified as a Rhizoctonia solani resistance gene in maize. ZmMDH7 is regulated by transcription factor ZmWRKY44 via pathogens challenge to elevate mitochondrial ROS and SA signaling pathway.
Luyang Wei, Junbin Chen, Chuang Liu, DanDan Liu, Meida Du, Shengfeng He, Wenyu Cheng, Vijai Bhadauria, You‐Liang Peng, Wangsheng Zhu   +9 more
wiley   +1 more source

Mitochondrial dysfunction in myeloid cells: a central deficit in autoimmune diseases. [PDF]

Trends Immunol
Kwong CJ, Kaplan MJ.
europepmc   +1 more source