Results 281 to 290 of about 296,707 (334)

Cyclic Strain and Macrophage‐Mediated Transport Govern Micron‐Sized PM2.5 Translocation across the Air–Blood Barrier

Advanced Science, EarlyView.
Using a dynamic, tri‐culture air‐blood barrier model, this study reveals that macrophage‐mediated transport governs micron‐sized particle translocation under cyclic strain. The process is highly size‐dependent that 2 µm particles are transported by macrophages, 0.2 µm particles diffuse passively, and 5 µm particles are effectively blocked.
Yongjian Li, Jinlong Xu, Zujie Gao, Haosheng Chen   +3 more
wiley   +1 more source

Expanding the Spectrum of Selective IgM Deficiency: From Infections to Immune Dysregulation. [PDF]

Int J Mol Sci
Fumagalli R, Saettini F.
europepmc   +1 more source

Cold Atmospheric Plasma‐Activated In Situ Hydrogel Induces Hair Regeneration Via Immune Microenvironment Remodeling

Advanced Science, EarlyView.
A cold atmospheric plasma‐activated in situ hydrogel (CAPgel/IL2) delivers reactive oxygen species and interleukin‐2 to modulate the hair follicle immune microenvironment, enhancing regulatory T‐cell expansion, dermal papilla cell proliferation, and the telogen‐to‐anagen transition for robust hair regeneration.
Jung Suk Kim, Junho Byun, Jaehyun Choi, Dongun Jin, Qiaoyun Li, Jaiwoo Lee, Han‐Gon Choi, Yu‐Kyoung Oh   +7 more
wiley   +1 more source

How the Cigarette Fire Burns the Rheumatoid Joints. [PDF]

JMA J
Tang IYK, Mok CC.
europepmc   +1 more source

Multi‐Omics Reveal the Dysregulated Gut‐Joint Axis in Knee Synovitis: Data from Two Osteoarthritis Studies in China

Advanced Science, EarlyView.
The “gut‐joint axis” in knee synovitis is uncovered. Integrated multi‐omics studies are conducted in two independent osteoarthritis cohorts. Synovitis is characterized an increased F/B ratio, as well as alterations of 3‐HIA, geranic acid, and TWEAK. Upregulated TWEAK receptor is found in high‐grade synovitis, and inversely correlated with lower TWEAK ...
Xiaoshuai Wang, Yi Liu, Ziying Sun, Jia Li, Zhihao Lu, Jiayuan Huang, Shixian Hu, Peihua Cao, Xiaolong Cao, Shangru Li, Jianzhao Ruan, Jinhui Liu, Jingyu Xie, Haitao Sun, Tianyu Chen, Shengfa Li, Zhaohua Zhu, Zhibo Wen, Rocky S. Tuan, David John Hunter, Zhong Alan Li, Dongquan Shi, Changhai Ding   +22 more
wiley   +1 more source

Autoimmune thyroid disease in infertility and assisted reproductive technology: A review. [PDF]

Porto Biomed J
Pires MI, Póvoa AM, Silva-Soares S.
europepmc   +1 more source

A Lung‐Immune Dual‐Humanized Mouse Using Cryopreserved Tissue Enables Infection and Immune Profiling of Human Common Cold Coronaviruses

Advanced Science, EarlyView.
Cryopreserved lung‐humanized mice overcome the dependency to fresh tissues and permit head‐to‐head profiling of all four human common cold coronaviruses versus SARS‐CoV‐2 infection; the model validates Paxlovid efficacy against HKU1 and, when coupled with human immune‐system engraftment, enables interrogation of lung‐resident human immunity and HKU1 ...
Chunyu Cheng, Jing Sun, Chun Lu, Qian Yu, Yiyun He, Bingqing Wu, Deshan Ren, Shuai Ding, Jincun Zhao, Yan Li   +9 more
wiley   +1 more source

Neutrophil extracellular traps in rheumatoid arthritis: pathogenic mechanisms and therapeutic potential. [PDF]

Front Immunol
Mao CL, Yu CH, Jiang SL, Ying ZH, Zhu XY.   +4 more
europepmc   +1 more source

Tubule‐Derived IFN‐α Promotes GSDMD‐Mediated Macrophage Pyroptosis to Drive Renal Inflammation and Fibrosis Through JAK2/STAT2 Activation

Advanced Science, EarlyView.
Mao and colleagues uncover a STAT2/IRF9‐dependent signaling axis through which tubular epithelial cell (TEC)‐derived IFN‐α induces gasdermin D (GSDMD)‐mediated pyroptosis in macrophages. This TEC‐macrophage feedback loop amplifies renal inflammation and fibrosis, providing mechanistic insight into the progression of chronic kidney disease and revealing
Yiping Xu, Yating Wang, Siming Jiang, Yi Li, Guanglan Li, Yuchu Liu, Siyuan Li, Yiming Zhou, Qinghua Liu, Yi Zhou, Wei Chen, Hongyu Li, Haiping Mao   +12 more
wiley   +1 more source

Microbial associations and viruses on the risk of celiac disease (MAVRiC): a longitudinal post-hoc case-cohort study. [PDF]

Sci Rep
Lynch KF, Triplett EW, Hyöty H, Ahrens AP, Laiho JE, Petrosino JF, Lloyd RE, Agardh D.   +7 more
europepmc   +1 more source