Results 291 to 300 of about 349,570 (384)

Gamma‐Glutamyl Cysteine Ligase Activity as a Proxy for Human T Cell Function and Drug‐Induced Immunosuppression

Advanced Science, EarlyView.
GLed, a reversible lanthanide‐based GSH sensor that enables real‐time, single‐cell measurement of Gamma–Glutamyl Cysteine Ligase (GCL) activity ‐whose role in human T cells remains unclear‐ is developed. GLed directly links GCL activity to T cell effector functions and reveals its modulation by immunosuppressive drugs, identifying GCL as a critical ...
Francisco Fueyo‐González, Carmen Salto‐Giron, Mehek Ningoo, Laura Espinar‐Barranco, Rafael Salto, Jose Manuel Paredes, Rosario Herranz, Angel Orte, Miguel Fribourg, Juan A. González‐Vera   +9 more
wiley   +1 more source

Research Progress on Biomaterials with Immunomodulatory Effects in Bone Regeneration

Advanced Science, EarlyView.
This review highlights recent advanced in immunomodulatory biomaterials for bone repair, focusing on design strategies, immune interactions, and clinical potential. Abstract The immune system plays a pivotal role in bone regeneration, and biomaterials engineered to modulate immune responses present a promising strategy for the treatment of extensive ...
Jianan Li, Ying Qu, Bingyang Chu, Tingkui Wu, Meng Pan, Dong Mo, Lang Li, Yang Ming, Yun Yang, Meng Wang, Xinlong He, Zhiyong Qian   +11 more
wiley   +1 more source

Respiratory infections in pregnancy and early life-association with the development of islet autoimmunity and type 1 diabetes in children: systematic review and meta-analysis of observational studies. [PDF]

EClinicalMedicine
Sung CJ, Plowman OM, Maxwell AJ, Rawlinson WD, Craig ME, Kim KW.   +5 more
europepmc   +1 more source

METTL3/ALKBH5‐Mediated N6‐Methyladenosine Modification Drives Macrophage M1 Polarization via the SLC15A3‐TASL‐IRF5 Signaling Axis in Psoriasis

Advanced Science, EarlyView.
m6A modification stabilizes Slc15a3 mRNA in macrophages, activating the SLC15A3‐TASL‐IRF5 axis and promoting psoriatic inflammation. Abstract Impaired N6‐methyladenosine (m6A) modification has been implicated in regulating various inflammatory diseases, but its role in psoriasis remains unclear.
Tao Huang, Shijun Chen, Ke Ding, Liyan Yuan, Weiqi Lv, Kechen Chen, Yuchen Liu, Dongzhao Ma, Xin Zhang, Xiaobo Wang, Guanzheng Luo, Bin Yang, Ying Lin, Zhili Rong   +13 more
wiley   +1 more source

Harnessing the Immunomodulation of UV‐Exposed Keratinocyte Extracellular Vesicles for Inflammatory Disorder Treatment

Advanced Science, EarlyView.
Adopting a paradigm shift that transforms a known health hazard as a potential therapeutic asset, a novel therapeutic strategy is set out to investigate for inflammatory conditions by leveraging immunosuppressive properties of UV‐irradiated keratinocytes.
Lu Liu, Ding Yang, Jingsen Ji, Gengyou Li, Haoting Chen, Yuying Yao, Chenxing Fu, Fangling Liao, Jinzhao Liu, Yaming Zhang, Zechuan Li, Jing Zhang, Huike Ma, Jingxia Zhao, Ying‐Shi Sun, Weisheng Guo, Weiping Wang   +16 more
wiley   +1 more source

Sex Bias in Autoimmunity: New Findings and New Opportunities. [PDF]

JID Innov
van Drongelen V, Rew J, Billi AC.
europepmc   +1 more source

Post‐Translational Modified Neoantigens in Autoimmune Diseases: Challenges of Immune Tolerance

Advanced Science, EarlyView.
Autoimmune diseases have a high incidence and disability rate. The pathogenesis of autoimmune diseases involves the interaction among genetic factors, environmental factors, and immune disorders. The post‐translational modified neoantigens are the key nodal of these three factors. And these post‐translational modified neoantigens, after being presented
Yue Zhai, Kefei Wu, Qi Lin, Zhenzhen Cao, Yankun Jia, Ping Zhu   +5 more
wiley   +1 more source

The 'autoimmunome' of centenarians. [PDF]

J Transl Autoimmun
Carrera-Bastos P, Plaza-Florido A, Santos-Lozano A, Borba V, Rodríguez-Romo G, García-Chico C, Lista S, Saco-Ledo G, Emanuele E, Shoenfeld Y, Lucia A.   +10 more
europepmc   +1 more source

Autoimmunity to Pancreatic juice in Crohn´s Disease [PDF]

, 1987
Finkbeiner, H., Lehnert, Peter, Normann, D., Otte, M., Stöcker, K., Stöcker, W., Ulrich, S.   +6 more
core  

Cardiovascular Disease Meets Cancer: Exploring the Epidemiology in China and Homotherapy Targeting Intersectional Mechanisms

Advanced Science, EarlyView.
Cardiovascular disease (CVD) and cancer are leading causes of death worldwide, with overlapping risk factors and pathophysiological mechanisms. This review explores shared pathways, including metabolic dysregulation, chronic inflammation, and gut microbiome alterations, highlighting dual‐benefit strategies such as lifestyle modifications and repurposed
Shihan Xiang, Yujie Shan, Shihong Xu, Jing Wang, Meng Luo, Jiaojiao Zhou, Qishan Chen   +6 more
wiley   +1 more source