Results 311 to 320 of about 349,570 (384)

Immune cell senescence in autoimmunity: implications for disease pathogenesis and therapeutic targeting. [PDF]

Front Immunol
Yin F, He Y, Li J, Gao Y.
europepmc   +1 more source

Critical Role of IL1R2‐ENO1 Interaction in Inhibiting Glycolysis‐Mediated Pyroptosis for Protection Against Lethal Sepsis

Advanced Science, EarlyView.
The authors have discovered that intracellular interleukin 1 receptor 2 (IL1R2) negatively regulates pyroptosis and inflammation by inhibiting glycolysis in sepsis. Soluble IL1R2 is released from macrophages undergoing pyroptosis. IL1R2 acts as a novel negative regulator of glycolysis by interacting with enolase 1 (ENO1), thereby inhibiting gasdermin D
Chuyi Tan, Han Ma, Jespar Chen, Gaifeng Ma, Alok Jha, Sipin Tan, Yaxi Zhu, Meidong Liu, Ke Liu, Xianzhong Xiao, Monowar Aziz, Huan Chen, Ping Wang, Huali Zhang   +13 more
wiley   +1 more source

Anti-thyroid Peroxidase Antibody Positivity and Chronic Hyperglycemia as Key Risk Factors for Peripheral Artery Disease in Type 2 Diabetes: A Retrospective Cohort Study. [PDF]

Cureus
Mahmud NMM, Mwangi DK, Shuvo RI, Juby T, Jagdewsing D, Elijah W, Naushad MSS, Iqbal F, Choudhary A, Ji X.   +9 more
europepmc   +1 more source

PFKFB2‐Driven Glycolysis Promotes Dendritic Cell Maturation and Exacerbates Acute Lung Injury

Advanced Science, EarlyView.
Paraquat (PQ) or lipopolysaccharide (LPS) exposure activates the HIF‐1α–PFKFB2 pathway, driving glycolysis in dendritic cells (DCs). This metabolic shift enhances DC maturation and immune activation, exacerbating acute lung injury (ALI). This study demonstrates that PFKFB2‐driven glycolytic reprogramming in DCs plays a critical role in the pathogenesis
Ding Yuan, Fang Yang, Linlin Hou, Yan Zhang, Xin Pang, Yuqi Du, Hongyi Yan, Huanzhou Zhu, Yue Cheng, Yue Wu, Pinpin Jiang, Mengnan Guo, Mengying Zhang, Jinjie Guo, Huihui Hao, Yong Jiang, Yi Li, Yanxia Gao   +17 more
wiley   +1 more source

Dysregulated Pro-inflammatory and Anti-inflammatory Cytokine Responses to Microbe-associated Molecular Patterns in X-linked Chronic Granulomatous Disease. [PDF]

In Vivo
Omaru N, Watanabe T, Hara A, Kurimoto M, Masuta Y, Otsuka Y, Masaki S, Minaga K, Kamata K, Honjo H, Arai Y, Yamashita K, Kudo M.   +12 more
europepmc   +1 more source

Tacrolimus (FK506) and therapy of human autoimmune disorders [PDF]

, 1996
Abu-Elmagd, K, Carroll, PB, Irish, W, McCauley, J, McMichael, J, Rilo, HR, Starzl, TE, Thomson, AW, Van Thiel, DH   +8 more
core  

Cationic Peptoids for Systemic In Vivo Cartilage‐Targeting

Advanced Science, EarlyView.
Systemically‐dosed Cy5‐labeled cationic peptoid probe (NlysO)7 (yellow) binds to the cartilage's glycosaminoglycan content in vivo across the entire body of a neonatal mouse imaged by light sheet fluorescence microscopy, revealing fluorescence uptake in generic cartilage as well as the developing and ossifying bones.
Chaonan Zhang, Rongmao Qiu, Yongjie Huang, Yinghua Liu, Kui Huang, Suwen Zhao, Yang Li   +6 more
wiley   +1 more source

Vitamin D deficiency in Hashimoto's thyroiditis: mechanisms, immune modulation, and therapeutic implications. [PDF]

Front Endocrinol (Lausanne)
Sun W, Ding C, Wang Y, Li G, Su Z, Wang X.   +5 more
europepmc   +1 more source

Wearable Bioelectronics for Home‐Based Monitoring and Treatment of Muscle Atrophy

Advanced Science, EarlyView.
As an inevitable disease, muscle atrophy has received more attention. Because the factors that induce this disease are diverse, achieving a complete cure is still impossible. Wearable bioelectronics provides a more comfortable, low‐cost, and efficient way of home care for the monitoring and treatment of muscle atrophy. Therefore, this review summarizes
Shuai Zhang, Renjie Tan, Shuo Meng, Ke Zhang, Jinlian Hu   +4 more
wiley   +1 more source

Nutrition and Autoimmune Diseases. [PDF]

Nutrients
Ruggeri RM, Hrelia S, Barbalace MC.
europepmc   +1 more source