Results 331 to 340 of about 207,009 (370)
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Current Opinion in Immunology, 2010
Abstract Autoimmune diseases occur when a sustained, specific, adaptive immune response is generated against self-components, and results in tissue damage or dysfunction. It is now clear that an autoimmune component is a feature of many human diseases.
Kazuhiko, Yamamoto, Mark, Shlomchik
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Abstract Autoimmune diseases occur when a sustained, specific, adaptive immune response is generated against self-components, and results in tissue damage or dysfunction. It is now clear that an autoimmune component is a feature of many human diseases.
Kazuhiko, Yamamoto, Mark, Shlomchik
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Immunometabolism and autoimmunity
Current Opinion in Immunology, 2020Over the last few years, immune cell metabolism has become one of the most stimulating areas of investigation in the field of immunology. Compelling evidence has revealed that metabolic pathways are closely associated to cell functions and immune cells adopt defined metabolic programs to sustain their activity and respond to micro-environmental demands.
Galgani M, Bruzzaniti S, Matarese G
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Infection, autoimmunity and autoimmune disease
1996Studies of the immune response of mammals to infectious agents have revealed that members of the hsp60 and hsp 70 family are highly immunodominant. Given their high conservation during evolution this was surprising, because of the apparent risk of triggering of autoimmunity and autoimmune disease during the defense of a mammal against infection ...
U. Feige, W. van Eden
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Clinics in Liver Disease, 2002
This chapter describes perturbations in the signaling, apoptotic, and regulatory pathways within the innate and adaptive immune systems that favor the development of autoimmune hepatitis. Molecular mimicry, neoantigens, epitope spread, and promiscuous targeting by activated lymphocytes are discussed, and the genetic predispositions implicated in the ...
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This chapter describes perturbations in the signaling, apoptotic, and regulatory pathways within the innate and adaptive immune systems that favor the development of autoimmune hepatitis. Molecular mimicry, neoantigens, epitope spread, and promiscuous targeting by activated lymphocytes are discussed, and the genetic predispositions implicated in the ...
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Autoimmunity and Autoimmune Diseases in the Elderly
2009In the majority of papers dealing with immune system changes, higher prevalence of autoimmunity and autoimmune diseases among elderly people is stressed as one of the factors confirming the changes of immune system function in aging. This statement is repeated for a very long time and most of the authors treat it as a “stone-carved” truth.
Ewa Bryl, Jacek M. Witkowski
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Best Practice & Research Clinical Gastroenterology, 2006
Autoimmune hepatitis (AIH) was the first chronic liver disease in which remission was achieved by immunosuppression. Prognosis is poor when left untreated. Since the original description in 1950 by Waldenström, the initially reported treatment option has remained until today and is the core of the basic therapeutic strategy of inducing remission with ...
Michael P. Manns +2 more
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Autoimmune hepatitis (AIH) was the first chronic liver disease in which remission was achieved by immunosuppression. Prognosis is poor when left untreated. Since the original description in 1950 by Waldenström, the initially reported treatment option has remained until today and is the core of the basic therapeutic strategy of inducing remission with ...
Michael P. Manns +2 more
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Engineering IL-2 for immunotherapy of autoimmunity and cancer
Nature reviews. Immunology, 2022Rosmely Hernandez +3 more
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Orvosi Hetilap, 2007
First the short history of the disease, then its etiopathogenesis, the role of genetic, environmental and immunologic factors are described. In the second part, the questions of diagnosis, differential diagnosis and the immunosuppressive treatment, with new therapeutic modalities and liver transplantation are discussed.
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First the short history of the disease, then its etiopathogenesis, the role of genetic, environmental and immunologic factors are described. In the second part, the questions of diagnosis, differential diagnosis and the immunosuppressive treatment, with new therapeutic modalities and liver transplantation are discussed.
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2011
The scarcity of Trypanosoma cruzi in inflammatory lesions of chronic Chagas disease led early investigators to suggest that tissue damage had an autoimmune nature. In spite of parasite persistence in chronic Chagas disease, several reports indicate that inflammatory tissue damage may not be correlated to the local presence of T. cruzi.
Edecio Cunha-Neto +3 more
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The scarcity of Trypanosoma cruzi in inflammatory lesions of chronic Chagas disease led early investigators to suggest that tissue damage had an autoimmune nature. In spite of parasite persistence in chronic Chagas disease, several reports indicate that inflammatory tissue damage may not be correlated to the local presence of T. cruzi.
Edecio Cunha-Neto +3 more
openaire +3 more sources