Results 331 to 340 of about 349,570 (384)

DAGLA autoantibody experience at Mayo Clinic. [PDF]

J Neurol
Vorasoot N, Isitan-Alkawadri C, Pillai B, Miske R, Dubey D, Gilligan M, Hahn S, Mills J, Pittock SJ, Zekeridou A, McKeon A.   +10 more
europepmc   +1 more source

Cellular Adaptation to Mechanical Stress Emerges via Cell Shrinkage Triggered by Nonlinear Calcium Elevation

Advanced Science, EarlyView.
Here, a decision‐making mechanism underlying mechanical adaptation is demonstrated. This study demonstrates that cellular adaptation to mechanical stress can be induced by applying low‐amplitude stretch to cells. When the stretch reaches a critical amplitude threshold, it triggers Ca2⁺‐dependent positive feedback, which induces cholesterol efflux and ...
Zhengyan Wang, Zihan Li, Lei Wang, Haitao Zhang, Xiaoshan Yang, Lili Bao, Geng Dou, Lili Ren, Yajing Fu, Lan Li, Shengkai Gong, Yang Zhou, Feng Ding, Lu Yu, Haotian Luo, Yao Liu, Fuyang Zhang, Hui Yu, Siying Liu, Xueming Liu, Fulan Wei, Shiyu Liu   +21 more
wiley   +1 more source

Beyond inflammation: the multifaceted therapeutic potential of targeting the CXCL8-CXCR1/2 axis in type 1 diabetes. [PDF]

Front Immunol
Fousteri G, Jones M, Novelli R, Boccella S, Brandolini L, Aramini A, Pozzilli P, Allegretti M.   +7 more
europepmc   +1 more source

STING COPII ER Export Trafficking and Signaling Primed by Phosphorylation Switches

Advanced Science, EarlyView.
This schematic outlines STING trafficking and signaling via coat protein II (COPII)‐mediated endoplasmic reticulum (ER) export. Following cyclic GMP‐AMP (cGAMP) stimulation, TANK‐binding kinase 1 (TBK1) activates on COPII vesicles, partially dissociating into the cytosol to phosphorylate ER‐localized STING, creating pSGME/pFS COPII‐sorting motifs ...
Yanan Nan, Dongxiao Cui, Jiajian Guo, Xiaojing Ma, Jiaming Wang, Linyue Guo, Tianyu Li, Mingrui Yang, Guangrui Huang, Anlong Xu, Wenfu Ma   +10 more
wiley   +1 more source

Self-Antigens Select B Cells: A New Perspective on B Cell Selection and Function. [PDF]

Eur J Immunol
Aoun M, Holmdahl R.
europepmc   +1 more source

USP8‐Governed MDA5 Homeostasis Promotes Innate Immunity and Autoimmunity

Advanced Science, EarlyView.
This study reveals that USP8 stabilizes MDA5 via AKT‐mediated phosphorylation (Ser718), enhancing their interaction and MDA5 deubiquitination. USP8 inactivation degrades MDA5, suppressing type I IFN and cytokine production. Pharmacological inhibition of USP8/AKT alleviates MDA5‐driven autoimmunity, demonstrating the USP8‐MDA5 axis as a therapeutic ...
Qimin Zhang, Shan Huang, Yan He, Weiwei Wang, Chao Tong, Mengru Ma, Manyu Zhao, Lian Yi, Klaus‐Peter Knobeloch, Peijing Zhang   +9 more
wiley   +1 more source

Coincidental Coexistence of Human T-lymphotropic Virus Type 1 (HTLV-1)-Associated Myelopathy/Tropical Spastic Paraparesis and Myasthenia Gravis in a Patient With Chronic HTLV-1 Infection: A Case Report. [PDF]

Cureus
Garma-Solis IJ, Zapata-Arceo FS, Ayuso-Diaz VM, Moreno-Enriquez A.   +3 more
europepmc   +1 more source

Editorial: Community series in emerging insights in controlling autoimmunity, volume II. [PDF]

Front Immunol
Bruno L, Bogdanos D, Maslinska M, Perricone C.   +3 more
europepmc   +1 more source

101 Lupus nephritis mortality by sex, age, geographic region, urbanization, and race/ethnicity: a nationwide population-based study

Lupus Science and Medicine
Snehin Rajkumar, Ram Raj Singh, Eric Yen
doaj   +1 more source

Causes of Down syndrome regression disorder: a scoping review. [PDF]

Dement Neuropsychol
Natividade MMP, Moreira AJ, Nassif LS, Dos Santos BRA, Borin MC, Alvares-Teodoro J, Acurcio FA, Guerra AA.   +7 more
europepmc   +1 more source