Results 111 to 120 of about 17,659,768 (189)

Targeting Bacterial Communication: Evaluating Phytochemicals as LuxS Inhibitors to Disrupt Quorum Sensing

Macromol
Bacterial quorum sensing (QS) is a critical communication process that regulates gene expression in response to population density, influencing activities such as biofilm formation, virulence, and antibiotic resistance.
Yiannis Sarigiannis, Christos Papaneophytou   +1 more
doaj   +1 more source

Interference With Quorum-Sensing Signal Biosynthesis as a Promising Therapeutic Strategy Against Multidrug-Resistant Pathogens

Frontiers in Cellular and Infection Microbiology, 2019
Faced with the global health threat of increasing resistance to antibiotics, researchers are exploring interventions that target bacterial virulence factors.
Osmel Fleitas Martínez, Osmel Fleitas Martínez, Pietra Orlandi Rigueiras, Állan da Silva Pires, William Farias Porto, William Farias Porto, William Farias Porto, Osmar Nascimento Silva, Cesar de la Fuente-Nunez, Cesar de la Fuente-Nunez, Cesar de la Fuente-Nunez, Cesar de la Fuente-Nunez, Cesar de la Fuente-Nunez, Octavio Luiz Franco, Octavio Luiz Franco, Octavio Luiz Franco   +15 more
doaj   +1 more source

Norepinephrine may promote the progression of Fusobacterium nucleatum related colorectal cancer via quorum sensing signalling

Virulence
Fusobacterium nucleatum (F. nucleatum) is closely correlated with tumorigenesis in colorectal cancer (CRC). We aimed to investigate the effects of host norepinephrine on the carcinogenicity of F. nucleatum in CRC and reveal the underlying mechanism.
Xinhao Du, Zhenzhen Tang, Li Yan, Ling Zhang, Qiao Zheng, Xianghao Zeng, Qing Hu, Qian Tian, Lanfan Liang, Xinyu Zhao, Jun Li, Ming Zhao, Xiangsheng Fu   +12 more
doaj   +1 more source

Detection of AI-2 Receptors in Genomes of <em>Enterobacteriaceae </em>Suggests a Role of Type-2 Quorum Sensing in Closed Ecosystems

Sensors, 2012
The LuxS enzyme, an S-ribosyl-homocysteine lyase, catalyzes the production of the signal precursor for autoinducer-2 mediated quorum sensing (QS-2) in <em>Vibrio</em>.
Brion Duffy, Fabio Rezzonico, Theo H. M. Smits   +2 more
doaj   +1 more source

Effects of vitamin B12 supply on cellular processes of the facultative vitamin B12 consumer Vibrio campbellii

Applied and Environmental Microbiology
Vitamin B12 (cobalamin, herein B12) is a key cofactor for most organisms being involved in essential metabolic processes. In microbial communities, B12 is often scarce, largely because only few prokaryotes can synthesize B12 de novo and are thus ...
Luna-Agrippina Groon, Stefan Bruns, Leon Dlugosch, Heinz Wilkes, Gerrit Wienhausen   +4 more
doaj   +1 more source

The Crystal Structure of the Escherichia coli Autoinducer-2 Processing Protein LsrF

PLoS ONE, 2009
Many bacteria produce and respond to the quorum sensing signal autoinducer-2 (AI-2). Escherichia coli and Salmonella typhimurium are among the species with the lsr operon, an operon containing AI-2 transport and processing genes that are up regulated in response to AI-2.
Diaz, Zamia Caridad, , '09, Xavier, K. B., Miller, Stephen T.   +2 more
openaire   +5 more sources

Three autoinducer molecules act in concert to control virulence gene expression in Vibrio cholerae [PDF]

, 2019
Bacteria use quorum sensing to monitor cell density and coordinate group behaviours. In Vibrio cholerae, the causative agent of the diarrheal disease cholera, quorum sensing is connected to virulence gene expression via the two autoinducer molecules, AI ...
Roman Herzog1, Nikolai Peschek1,2, Kathrin S. Fr ¨ ohlich 1, Kilian Schumacher1 and Kai Papenfort
core   +1 more source

Novel autoinducer molecules and uses therefor [PDF]

, 2002
Novel bacterial quinolone signal molecules and, more particularly, pseudomonas quinolone signal ('PQS') molecules, e.g., 2-heptyl-3hydroxy-4-quinolone, and analogs and derivatives thereof are described, Therapeutic compositions containing the molecules ...
Greenberg, Everett, Iglewski, Barbara, Kende, Andrew, Pesci, Everett, Milbank, Jared B. J., Pearson, James P.   +5 more
core   +2 more sources

Activation of aryl hydrocarbon receptor by autoinducer-2 alleviates intestinal injury in a neonatal mouse model of necrotizing enterocolitis

陆军军医大学学报
Objective To investigate the mechanism of autoinducer-2(AI-2) in relieving intestinal injury in neonatal mouse model of necrotizing enterocolitis (NEC).
HU Lingjun, LU Qi, LU Qi
doaj   +1 more source

The absence of luxS reduces the invasion of Avibacterium paragallinarum but is not essential for virulence

Frontiers in Veterinary Science
The contagious respiratory pathogen, Avibacterium paragallinarum, contributes to infectious coryza in poultry. However, commercial vaccines have not shown perfect protection against infectious coryza.
Donghai Li, Donghai Li, Caiyun Huo, Guiping Li, Menghan Zhu, Fuzhou Xu, Jian Qiao, Huiling Sun   +7 more
doaj   +1 more source