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Dissecting of the AI-2/LuxS Mediated Growth Characteristics and Bacteriostatic Ability of Lactiplantibacillus plantarum SS-128 by Integration of Transcriptomics and Metabolomics

Foods, 2022
Lactiplantibacillus plantarum could regulate certain physiological functions through the AI-2/LuxS-mediated quorum sensing (QS) system. To explore the regulation mechanism on the growth characteristics and bacteriostatic ability of L. plantarum SS-128, a
Yilin Qian, Yuan Li, Tengteng Xu, Huijuan Zhao, Mingyong Zeng, Zunying Liu   +5 more
doaj   +2 more sources

The Role of luxS in the Middle Ear Streptococcus pneumoniae Isolate 947 [PDF]

Pathogens, 2022
The LuxS protein, encoded by luxS, is required for the production of autoinducer 2 (AI-2) in Streptococcus pneumoniae. The AI-2 molecule serves as a quorum sensing signal, and thus regulates cellular processes such as carbohydrate utilisation and biofilm
Alexandra Tikhomirova, Erin B. Brazel, Kimberley T. McLean, Hannah N. Agnew, James C. Paton, Claudia Trappetti   +5 more
doaj   +2 more sources

Overexpression of luxS Promotes Stress Resistance and Biofilm Formation of Lactobacillus paraplantarum L-ZS9 by Regulating the Expression of Multiple Genes

Frontiers in Microbiology, 2018
Probiotics have evoked great interest in the past years for their beneficial effects. The aim of this study was to investigate whether luxS overexpression promotes the stress resistance of Lactobacillus paraplantarum L-ZS9.
Pinglan Li, Ruiyun Wu, Jinlan Zhang
exaly   +3 more sources

In-Silico Prediction and Modeling of the Quorum Sensing LuxS Protein and Inhibition of AI-2 Biosynthesis in Aeromonas hydrophila

Molecules, 2018
luxS is conserved in several bacterial species, including A. hydrophila, which causes infections in prawn, fish, and shrimp, and is consequently a great risk to the aquaculture industry and public health. luxS plays a critical role in the biosynthesis of
Wanxin Li, Zujie Yao, Wenxiong Lin
exaly   +3 more sources

Modulation of Campylobacter jejuni Motility, Adhesion to Polystyrene Surfaces, and Invasion of INT407 Cells by Quorum-Sensing Inhibition

Microorganisms, 2020
Campylobacter jejuni is a major foodborne pathogen, and the LuxS-mediated quorum-sensing (QS) system influences its motility, biofilm formation, invasion, host colonization, and virulence. QS therefore represents a target for the control of C.
Katarina Šimunović, Dina Ramić, Changyun Xu, Sonja Smole Možina   +3 more
doaj   +1 more source

mRNA-Seq reveals the quorum sensing system luxS gene contributes to the environmental fitness of Streptococcus suis type 2

BMC Microbiology, 2021
Background Streptococcus suis type 2 (SS2) is an important zoonotic pathogen. We have previously reported the structure of LuxS protein and found that the luxS gene is closely related to biofilm, virulence gene expression and drug resistance of SS2 ...
Jinpeng Li, Yuxin Wang, Yanbin Du, Hui Zhang, Qingying Fan, Liyun Sun, Li Yi, Shaohui Wang, Yang Wang   +8 more
doaj   +1 more source

luxS contributes to intramacrophage survival of Streptococcus agalactiae by positively affecting the expression of fruRKI operon

Veterinary Research, 2023
The LuxS quorum sensing system is a widespread system employed by many bacteria for cell-to-cell communication. The luxS gene has been demonstrated to play a crucial role in intramacrophage survival of piscine Streptococcus agalactiae, but the underlying
Qing Cao, Yuhao Dong, Changming Guo, Shuting Ji, Meng Nie, Guangjin Liu, Xihe Wan, Chengping Lu, Yongjie Liu   +8 more
doaj   +1 more source

Functional analysis of the group A streptococcal luxS/AI-2 system in metabolism, adaptation to stress and interaction with host cells

BMC Microbiology, 2008
Background The luxS/AI-2 signaling pathway has been reported to interfere with important physiological and pathogenic functions in a variety of bacteria.
Zinkl Daniela, Hassler Christine, Pirzada Zaid A, Janapatla Rajendra P, Siller Maria, Charpentier Emmanuelle   +5 more
doaj   +1 more source

Integration of AI-2 Based Cell-Cell Signaling with Metabolic Cues in Escherichia coli. [PDF]

PLoS ONE, 2016
The quorum sensing molecule Autoinducer-2 (AI-2) is generated as a byproduct of activated methyl cycle by the action of LuxS in Escherichia coli. AI-2 is synthesized, released and later internalized in a cell-density dependent manner. Here, by mutational
Arindam Mitra, Christopher D Herren, Isha R Patel, Adam Coleman, Suman Mukhopadhyay   +4 more
doaj   +1 more source

LsrB-based and temperature-dependent identification of bacterial AI-2 receptor

AMB Express, 2017
The luxS gene is required for autoinducer-2 (AI-2) synthesis in many bacterial species. AI-2 is taken up by a specific receptor to regulate multiple bacterial activities.
Yuxi Zhang, Kezong Qi, Yawei Jing, Jiakun Zuo, Jiangang Hu, Xiaolong Lv, Zhaoguo Chen, Rongsheng Mi, Yan Huang, Shengqing Yu, Xiangan Han   +10 more
doaj   +1 more source