Results 31 to 40 of about 2,002 (238)

The absence of luxS reduces the invasion of Avibacterium paragallinarum but is not essential for virulence

Frontiers in Veterinary Science
The contagious respiratory pathogen, Avibacterium paragallinarum, contributes to infectious coryza in poultry. However, commercial vaccines have not shown perfect protection against infectious coryza.
Donghai Li, Donghai Li, Caiyun Huo, Guiping Li, Menghan Zhu, Fuzhou Xu, Jian Qiao, Huiling Sun   +7 more
doaj   +1 more source

Structural and Functional Characterization of the Signaling Molecule Autoinducer-2 Synthesis Enzyme S-Ribosylhomocysteinase in Limosilactobacillus fermentum [PDF]

Shipin Kexue
S-ribosylhomocysteinase (also referred to as LuxS protein) is an important enzyme involved in the biosynthesis of autoinducer-2 (AI-2) as a signaling molecule.
WEI Guangqiang, WANG Teng, XU Ziqi, WANG Yuzhu, ZHANG Wenbin, LI Xinglun, HUANG Aixiang
doaj   +1 more source

Effect of Commiphora myrrha Extract on Biofilm Formation of Lactobacillus Isolated from Teeth Caries

Medical Journal of Babylon
Background: Dental caries starts, progresses, and results in tooth decay due to biological factors such as cariogenic bacteria. Streptococcus mutans and Lactobacillus are considered to be the main microorganisms involved in this condition. Objectives: To
Fatima Mohammed Jabbar, Sanaa Rahman Oleiwi   +1 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

The luxS mutation causes loosely-bound biofilms in Shewanella oneidensis

BMC Research Notes, 2011
Background The luxS gene in Shewanella oneidensis was shown to encode an autoinducer-2 (AI-2)-like molecule, the postulated universal bacterial signal, but the impaired biofilm growth of a luxS deficient mutant could not be restored by AI-2, indicating ...
Wagner-Döbler Irene, Wissing Josef, Jänsch Lothar, Bodor Agnes M   +3 more
doaj   +1 more source

Uncovering the link between the SpnIII restriction modification system and LuxS in Streptococcus pneumoniae meningitis isolates

Frontiers in Cellular and Infection Microbiology, 2023
Streptococcus pneumoniae is capable of randomly switching their genomic DNA methylation pattern between six distinct bacterial subpopulations (A-F) via recombination of a type 1 restriction-modification locus, spnIII.
Hannah N. Agnew, John M. Atack, John M. Atack, Ann R.D. Fernando, Sophie N. Waters, Mark van der Linden, Erin Smith, Andrew D. Abell, Erin B. Brazel, James C. Paton, Claudia Trappetti   +10 more
doaj   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Characterization of AI-2/LuxS quorum sensing system in antibiotic resistance, pathogenicity of non carbapenemase-producing carbapenem-resistant Escherichia coli

BMC Microbiology
Background As a quorum sensing system, LuxS/AI-2 is closely associated with bacterial growth, biofilm formation, and virulence. As yet, it is not known how the luxS is associated with a diverse array of physiological activities in non- carbapenemase ...
Xiaohong Xu, Meili Cai, Huishan Lai, Siyan Lian, Liping Hu, Yingping Cao   +5 more
doaj   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source