Clostridioides difficile LuxS mediates inter-bacterial interactions within biofilms [PDF]
Scientific Reports, 2019 The anaerobic gut pathogen, Clostridioides difficile, forms adherent biofilms that may play an important role in recurrent C. difficile infections. The mechanisms underlying C.
Ross T. Slater +4 more
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2D proteome analysis initiates new Insights on the
BMC Microbiology, 2009 Background Quorum sensing is a term describing a bacterial communication system mediated by the production and recognition of small signaling molecules. The LuxS enzyme, catalyzing the synthesis of AI-2, is conserved in a wide diversity of bacteria. AI-2
Vanderleyden Jos +5 more
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Overexpression of luxS Cannot Increase Autoinducer-2 Production, Only Affect the Growth and Biofilm Formation in Streptococcus suis [PDF]
The Scientific World Journal, 2013 LuxS/AI-2 quorum sensing (QS) system involves the production of cell signaling molecules via luxS-based autoinducer-2 (AI-2). LuxS has been reported to plays critical roles in regulating various behaviors of bacteria.
Yang Wang +5 more
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Quorum sensing LuxS/autoinducer-2 inhibits Enterococcus faecalis biofilm formation ability
Journal of Applied Oral Science, 2018 Objective: To investigate the relation between biofilm formation ability and quorum sensing gene LuxS/AI-2. Materials and Methods: Enterococcus faecalis (E. faecalis) standard strain ATCC 29212 was used in the study.
Yue Yang +3 more
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LuxS-independent formation of AI-2 from ribulose-5-phosphate [PDF]
BMC Microbiology, 2008 Background In many bacteria, the signal molecule AI-2 is generated from its precursor S-ribosyl-L-homocysteine in a reaction catalysed by the enzyme LuxS.
Hardie Kim R +3 more
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Bifidobacteria exhibit LuxS-dependent autoinducer 2 activity and biofilm formation. [PDF]
PLoS ONE, 2014 Autoinducer-2 (AI-2) molecules are one class of signalling molecules involved in gene regulation dependent on population density in a mechanism commonly referred to as quorum sensing (QS).
Zhongke Sun +4 more
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Helicobacter pylori luxS mutants cause hyperinflammatory responses during chronic infection [PDF]
Microbiology SpectrumHelicobacter pylori infects roughly half the world’s population, causing gastritis, peptic ulcers, and gastric cancer in a subset. These pathologies occur in response to a chronic inflammatory state, but it is not fully understood how H.
Christina Yang +6 more
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Role of Neisseria meningitidis luxS in Cell-to-Cell Signaling and Bacteremic Infection.
, 2002 Numerous pathogenic bacteria contain luxS, which is required for autoinducer-2 production. Here, we demonstrate that Neisseria meningitidis contains a functional copy of luxS that is necessary for full meningococcal virulence; strains with a luxS ...
Winzer, Klaus +7 more
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BMC Microbiology, 2010 Background LuxS may function as a metabolic enzyme or as the synthase of a quorum sensing signalling molecule, auto-inducer-2 (AI-2); hence, the mechanism underlying phenotypic changes upon luxS inactivation is not always clear.
Doherty Neil +7 more
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Crystal Structure and Identification of Two Key Amino Acids Involved in AI-2 Production and Biofilm Formation in Streptococcus suis LuxS. [PDF]
PLoS ONE, 2015 Streptococcus suis has emerged as an important zoonotic pathogen that causes meningitis, arthritis, septicemia and even sudden death in pigs and humans.
Yang Wang +6 more
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