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Mutational Analysis of a Nucleosidase Involved in Quorum-Sensing Autoinducer-2 Biosynthesis

Biochemistry, 2005
5'-Methylthioadenosine/S-adenosylhomocysteine nucleosidase (MTAN) is important in a number of cellular functions such as polyamine biosynthesis, methionine salvaging, biological methylation, and quorum sensing. The nucleosidase is found in many microbes but not in mammalian systems, thus making MTAN a broad-spectrum antimicrobial drug target. Substrate
Jeffrey E, Lee   +5 more
openaire   +2 more sources

Autoinducer-2 bioassay is a qualitative, not quantitative method influenced by glucose

Journal of Microbiological Methods, 2006
Autoinducer-2 (AI-2) is a cell-to-cell signaling molecule which is thought to be utilized for quorum sensing processes by a variety of prokaryotic species. This molecule is usually detected using a so-called autoinducer bioassay, which relies on the ability of a Vibrio harveyi reporter strain to produce light in response to AI-2. However, as previously
Yevgeniy, Turovskiy   +1 more
openaire   +2 more sources

Autoinducer‐2 Quorum Sensing Is an Active Universal Signaling System in Sociomicrobiology

Journal of Basic Microbiology
ABSTRACTAutoinducer‐2 (AI‐2) is a bacterial quorum sensing (QS) signaling molecule that regulates inter‐specific and intraspecific bacterial communication in complex ecological environments. Here, we systematically analyzed the distribution of AI‐2 QS‐related proteins (synthases and receptors) in the domain bacteria, explored the evolution and ...
Dingqi Liu   +6 more
openaire   +2 more sources

Enzymatic Synthesis of a Quorum-Sensing Autoinducer Through Use of Defined Substrates

Science, 1996
Margret I Moré   +2 more
exaly  

Spatial Heterogeneity of Autoinducer Regulation Systems

Sensors, 2012
Burkhard A Hense, Christina Kuttler
exaly  

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